Effect of aromatizable and unaromatizable androgen replacement in hypogonadal men on GH responsiveness

Clinical Endocrinology

Volumn 70, Issue 1, 2009, Pages 109-115

  Gleeson, Helena K ^a   Shalet, Stephen M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; GROWTH HORMONE BINDING PROTEIN; HUMAN GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; TESTOSTERONE;

ADULT; ANDROGEN BLOOD LEVEL; ANDROGEN THERAPY; AROMATIZATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG FORMULATION; HORMONE RESPONSE; HUMAN; HYPOGONADISM; MALE; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; ANDROGENS; DIHYDROTESTOSTERONE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; HYPOGONADISM; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; TESTOSTERONE;

EID: 58149162991     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03312.x     Document Type: Article

References (33)

1. Dawson-Hughes, B., Stern, D., Goldman, J. Reichlin, S. (1986) Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement. Journal of Clinical Endocrinology and Metabolism, 63, 424 432.
2. Leung, K.C., Johannsson, G., Leong, G.M. Ho, K.K. (2004) Estrogen regulation of growth hormone action. Endocrine Reviews, 25, 693 721.
3. Liu, L., Merriam, G.R. Sherins, R.J. (1987) Chronic sex steroid exposure increases mean plasma growth hormone concentration and pulse amplitude in men with isolated hypogonadotropic hypogonadism. Journal of Clinical Endocrinology and Metabolism, 64, 651 656.
4. Veldhuis, J.D., Keenan, D.M., Mielke, K., Miles, J.M. Bowers, C.Y. (2005) Testosterone supplementation in healthy older men drives GH and IGF-1 secretion without potentiating peptidyl secretagogue efficacy. European Journal of Endocrinology, 153, 577 586.
5. Weissberger, A.J. Ho, K.K. (1993) Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization. Journal of Clinical Endocrinology and Metabolism, 76, 1407 1412.
6. Metzger, D.L. Kerrigan, J.R. (1994) Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence. Journal of Clinical Endocrinology and Metabolism, 79, 513 518.
7. Veldhuis, J.D., Anderson, S.M., Iranmanesh, A. Bowers, C.Y. (2005) Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations. Journal of Clinical Endocrinology and Metabolism, 90, 1613 1617.
8. Fisker, S., Norrelund, H., Juul, A., Skakkebaek, N.E., Christiansen, J.S. Jorgensen, J.O. (2001) The growth hormone (GH)-insulin-like growth factor axis during testosterone replacement therapy in GH-treated hypopituitary males. Growth Hormone and IGF Research, 11, 104 109.
9. Span, J.P., Pieters, G.F., Sweep, C.G., Hermus, A.R. Smals, A.G. (2000) Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement. Journal of Clinical Endocrinology and Metabolism, 85, 1121 1125.
10. Gibney, J., Wolthers, T., Johannsson, G., Umpleby, A.M. Ho, K.K. (2005) Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men. American Journal of Physiology. Endocrinology and Metabolism, 289, E266 E271.
11. Johannsson, G., Gibney, J., Wolthers, T., Leung, K.C. Ho, K.K. (2005) Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men. Journal of Clinical Endocrinology and Metabolism, 90, 3989 3994.
12. Giannoulis, M.G., Sonksen, P.H., Umpleby, M., Breen, L., Pentecost, C., Whyte, M., McMillan, C.V., Bradley, C. Martin, F.C. (2006) The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. Journal of Clinical Endocrinology and Metabolism, 91, 477 484.
13. Coutant, R., de Casson, F.B., Rouleau, S., Douay, O., Mathieu, E., Gatelais, F., Bouhours-Nouet, N., Voinot, C., Audran, M. Limal, J.M. (2004) Divergent effect of endogenous and exogenous sex steroids on the insulin-like growth factor I response to growth hormone in short normal adolescents. Journal of Clinical Endocrinology and Metabolism, 89, 6185 6192.
14. Craft, W.H. Underwood, L.E. (1984) Effect of androgens on plasma somatomedin-C/insulin-like growth factor I responses to growth hormone. Clinical Endocrinology, 20, 549 554.
15. Parker, M.W., Johanson, A.J., Rogol, A.D., Kaiser, D.L. Blizzard, R.M. (1984) Effect of testosterone on somatomedin-C concentrations in prepubertal boys. Journal of Clinical Endocrinology and Metabolism, 58, 87 90.
16. Brill, K.T., Weltman, A.L., Gentili, A., Patrie, J.T., Fryburg, D.A., Hanks, J.B., Urban, R.J. Veldhuis, J.D. (2002) Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. Journal of Clinical Endocrinology and Metabolism, 87, 5649 5657.
17. Blackman, M.R., Sorkin, J.D., Munzer, T., Bellantoni, M.F., Busby-Whitehead, J., Stevens, T.E., Jayme, J., O'Connor, K.G., Christmas, C., Tobin, J.D., Stewart, K.J., Cottrell, E., St Clair, C., Pabst, K.M. Harman, S.M. (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. Journal of the American Medical Association, 288, 2282 2292.
18. Gleeson, H.K. Shalet, S.M. (2005) GH responsiveness varies during the menstrual cycle. European Journal of Endocrinology, 153, 775 779.
19. Lissett, C.A. Shalet, S.M. (2003) The impact of dose and route of estrogen administration on the somatotropic axis in normal women. Journal of Clinical Endocrinology and Metabolism, 88, 4668 4672.
20. Lieberman, S.A., Mitchell, A.M., Marcus, R., Hintz, R.L. Hoffman, A.R. (1994) The insulin-like growth factor I generation test: resistance to growth hormone with aging and estrogen replacement therapy. Hormone and Metabolic Research, 26, 229 233.
21. Lissett, C.A. Shalet, S.M. (2003) The insulin-like growth factor-I generation test: peripheral responsiveness to growth hormone is not decreased with ageing. Clinical Endocrinology, 58, 238 245.
22. Leung, D.W., Spencer, S.A., Cachianes, G., Hammonds, R.G., Collins, C., Henzel, W.J., Barnard, R., Waters, M.J. Wood, W.I. (1987) Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature, 330, 537 543.
23. Gleeson, H.K., Lissett, C.A. Shalet, S.M. (2005) Insulin-like growth factor-I response to a single bolus of growth hormone is increased in obesity. Journal of Clinical Endocrinology and Metabolism, 90, 1061 1067.
24. Keenan, B.S., Richards, G.E., Mercado, M., Dallas, J.S., Eakman, G.D. Baumann, G. (1996) Androgen regulation of growth hormone binding protein. Metabolism, 45, 1521 1526.
25. Ip, T.P., Hoffman, D.M., O'Sullivan, A.J., Leung, K.C. Ho, K.K. (1995) Do androgens regulate growth hormone-binding protein in adult man? Journal of Clinical Endocrinology and Metabolism, 80, 1278 1282.
26. Fisker, S. (2006) Physiology and pathophysiology of growth hormone-binding protein: methodological and clinical aspects. Growth Hormone and IGF Research, 16, 1 28.
27. Link, K., Blizzard, R.M., Evans, W.S., Kaiser, D.L., Parker, M.W. Rogol, A.D. (1986) The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. Journal of Clinical Endocrinology and Metabolism, 62, 159 164.
28. Fryburg, D.A., Weltman, A., Jahn, L.A., Weltman, J.Y., Samojlik, E., Hintz, R.L. Veldhuis, J.D. (1997) Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone (GH)-releasing hormone-stimulated GH secretion in healthy men: impact of gonadal steroid and GH secretory changes on metabolic outcomes. Journal of Clinical Endocrinology and Metabolism, 82, 3710 3719.
29. Gentili, A., Mulligan, T., Godschalk, M., Clore, J., Patrie, J., Iranmanesh, A. Veldhuis, J.D. (2002) Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men. Journal of Clinical Endocrinology and Metabolism, 87, 825 834.
30. Malhotra, A., Poon, E., Tse, W.Y., Pringle, P.J., Hindmarsh, P.C. Brook, C.G. (1993) The effects of oxandrolone on the growth hormone and gonadal axes in boys with constitutional delay of growth and puberty. Clinical Endocrinology, 38, 393 398.
31. Hobbs, C.J., Plymate, S.R., Rosen, C.J. Adler, R.A. (1993) Testosterone administration increases insulin-like growth factor-I levels in normal men. Journal of Clinical Endocrinology and Metabolism, 77, 776 779.
32. Giustina, A., Scalvini, T., Tassi, C., Desenzani, P., Poiesi, C., Wehrenberg, W.B., Rogol, A.D. Veldhuis, J.D. (1997) Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone. Journal of Clinical Endocrinology and Metabolism, 82, 1210 1219.
33. Rooman, R.P., De Beeck, L.O., Martin, M., van Doorn, J., Mohan, S. Du Caju, M.V. (2005) Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. European Journal of Endocrinology, 152, 597 604.