Viral proteins killing tumor cells: New weapons in the fight against cancer

Cancer Biology and Therapy

Volumn 7, Issue 9, 2008, Pages 1374-1376

  Nüesch, Jürg P F ^b   Bär, Séverine ^b   Rommelaere, Jean ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b NONE

Author keywords

Anti cancer treatment; Apoptosis; Death pathways; Oncotoxicity; Programmed cell death; Tumor cell death; Viral proteins

Indexed keywords

ANAPHASE PROMOTING COMPLEX; APOPTIN; DNA; TUMOR NECROSIS FACTOR RECEPTOR; UBIQUITIN PROTEIN LIGASE; VIRUS PROTEIN; CAPSID PROTEIN; UNCLASSIFIED DRUG; VP3 PROTEIN, CHICKEN ANEMIA VIRUS;

APOPTOSIS; CANCER GROWTH; CELL DIVISION; NEOPLASM; NOTE; PROTEIN EXPRESSION; TUMOR CELL; ADENOVIRUS; ANIMAL; BIOLOGICAL MODEL; CELL DEATH; DISEASE MODEL; DRUG EFFECT; GENE VECTOR; GENETICS; METABOLISM; MOUSE; MOUTH TUMOR; PATHOLOGY;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CAPSID PROTEINS; CELL DEATH; DISEASE MODELS, ANIMAL; GENETIC VECTORS; MICE; MODELS, BIOLOGICAL; MOUTH NEOPLASMS;

EID: 58149161889     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.9.6743     Document Type: Note

References (34)

1. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British journal of cancer 1972; 26:239-57.
2. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annual review of biochemistry 1999; 68:383-424.
3. Elmore S. Apoptosis: a review of programmed cell death. Toxicologic pathology 2007; 35:495-516.
4. Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer biology & therapy 2005; 4:139-63.
5. Kaufmann SH, Hengartner MO. Programmed cell death: alive and well in the new millennium. Trends in cell biology 2001; 11:526-34.
6. Kuribayashi K, El-Deiry WS. Regulation of programmed cell death by the p53 pathway. Advances in experimental medicine and biology 2008; 615:201-21.
7. Baptiste-Okoh N, Barsotti AM, Prives C. A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America 2008; 105:1937-42.
8. Morales A, Lee H, Goni FM, Kolesnick R, Fernandez-Checa JC. Sphingolipids and cell death. Apoptosis 2007; 12:923-39.
9. Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nature reviews 2004; 4:592-603.
10. Sivaprasad U, Machida YJ, Dutta A. APC/C - the master controller of origin licensing? Cell division 2007; 2:8.
11. Hill MM, Hemmings BA. Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacology & therapeutics 2002; 93:243-51.
12. Hay S, Kannourakis G. A time to kill: viral manipulation of the cell death program. The Journal of general virology 2002; 83:1547-64.
13. Schoop RAL, Baatenburg de Jong RJ and Noteborn MHM. Apoptin induces apoptosis in an Oral Cancer Mouse Model. Cancer Biology & Ther 2008; 7.
14. Heilman DW, Green MR, Teodoro JG. The anaphase promoting complex: a critical target for viral proteins and anti-cancer drugs. Cell cycle (Georgetown, Tex) 2005; 4:560-3.
15. Maddika S, Bay GH, Kroczak TJ, Ande SR, Maddika S, Wiechec E, Gibson SB, Los M. Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death. Cell proliferation 2007; 40:835-48.
16. Maddika S, Booy EP, Johar D, Gibson SB, Ghavami S, Los M. Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway. Journal of cell science 2005; 118:4485-93.
17. Liu X, Elojeimy S, El-Zawahry AM, Holman DH, Bielawska A, Bielawski J, Rubinchik S, Guo GW, Dong JY, Keane T, Hannun YA, Tavassoli M, Norris JS. Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther 2006; 14:637-46.
18. Danen-van Oorschot AA, den Hollander AI, Takayama S, Reed JC, van der Eb AJ, Noteborn MH. BAG-1 inhibits p53-induced but not apoptin-induced apoptosis. Apoptosis 1997; 2:395-402.
19. Danen-Van Oorschot AA, Zhang YH, Leliveld SR, Rohn JL, Seelen MC, Bolk MW, Van Zon A, Erkeland SJ, Abrahams JP, Mumberg D, Noteborn MH. Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis. The Journal of biological chemistry 2003; 278:27729-36.
20. Lee YH, Cheng CM, Chang YF, Wang TY, Yuo CY. Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. Biochemical and biophysical research communications 2007; 354:391-5.
21. Rohn JL, Zhang YH, Leliveld SR, Danen-van Oorschot AA, Henriquez NV, Abrahams JP, Noteborn MH. Relevance of apoptin's integrity for its functional behavior. Journal of virology 2005; 79:1337-8.
22. Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V. HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. PLoS pathogens 2006; 2:127.
23. Coffey CM, Sheh A, Kim IS, Chandran K, Nibert ML, Parker JS. Reovirus outer capsid protein micro1 induces apoptosis and associates with lipid droplets, endoplasmic reticulum, and mitochondria. Journal of virology 2006; 80:8422-38.
24. Kornitzer D, Sharf R, Kleinberger T. Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome. The Journal of cell biology 2001; 154:331-44.
25. Shtrichman R, Sharf R, Barr H, Dobner T, Kleinberger T. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A. Proceedings of the National Academy of Sciences of the United States of America 1999; 96:10080-5.
26. Mousset S, Ouadrhiri Y, Caillet-Fauquet P, Rommelaere J. The cytotoxicity of the autonomous parvovirus minute virus of mice nonstructural proteins in FR3T3 rat cells depends on oncogene expression. Journal of virology 1994; 68:6446-53.
27. 2. Cell Growth Differ 1995; 6:781-7.
28. Rayet B, Lopez-Guerrero JA, Rommelaere J, Dinsart C. Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway. Journal of virology 1998; 72:8893-903.
29. Di Piazza M, Mader C, Geletneky K, Herrero YCM, Weber E, Schlehofer J, Deleu L, Rommelaere J. Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. Journal of virology 2007; 81:4186-98.
30. Lachmann S, Bar S, Rommelaere J, Nuesch JP. Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts. Cellular microbiology 2008; 10:755-69.
31. Nuesch JP, Lachmann S, Rommelaere J. Selective alterations of the host cell architecture upon infection with parvovirus minute virus of mice. Virology 2005; 331:159-74.
32. Nuesch JP, Rommelaere J. A viral adaptor protein modulating casein kinase II activity induces cytopathic effects in permissive cells. Proceedings of the National Academy of Sciences of the United States of America 2007; 104:12482-7.
33. van der Eb MM, Pietersen AM, Speetjens FM, Kuppen PJ, van de Velde CJ, Noteborn MH, Hoeben RC. Gene therapy with apoptin induces regression of xenografted human hepatomas. Cancer gene therapy 2002; 9:53-61.
34. Peng DJ, Sun J, Wang YZ, Tian J, Zhang YH, Noteborn MH, Qu S. Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor. Cancer gene therapy 2007; 14:66-73.