Debottlenecking the Synthesis Route of Asenapine

Organic Process Research and Development

Volumn 12, Issue 2, 2008, Pages 196-201

  Van Der Linden, Marco ^a   Roeters, Theo ^a   Harling, Ramon ^a   Stokkingreef, Edwin ^a   Gelpke, Arjan Sollewijn ^a   Kemperman, Gerjan ^a  

^a Department of Process Chemistry ^*  (Netherlands)

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Indexed keywords

EID: 58149157588     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op700240c     Document Type: Article

References (6)

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2. Shahid, M.; Walker, G. B.; Zom, S. H.; Wong, E. H. F. J. Psychopharmacol. 2007, in press.
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4. van der Burg, W. J. Tetracyclic derivatives and pharmaceutical compositions of matter. U.S. patent 4,145,434, 1979.
5. Harris, T. W.; Smith, H. E.; Mobley, P. L.; Manier, D. H.; Sulser. F. J. Med. Chem. 1982, 25, 855-858.
6. Kemperman, G. J.; van der Linden, J. J. M.; Reeder, M. Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12btetrahydro- lH-dibenz[2,3;6,7]oxepmo[4,5-c|pyrrole. Patent WO2006/106136, 2006.