메뉴 건너뛰기




Volumn 76, Issue 2, 2009, Pages 101-111

Selective killing of leukemia and lymphoma cells ectopically expressing hCGβ by a conjugate of curcumin with an antibody against hCGβ subunit

Author keywords

Acute myeloid leukemia; Curcumin antibody conjugate; Histiocytic lymphoma; Human chorionic gonadotropin beta; MOLT 4; T lymphoblastic leukemia; U 937

Indexed keywords

ANTIBODY CONJUGATE; CHORIONIC GONADOTROPIN ANTIBODY; CHORIONIC GONADOTROPIN BETA SUBUNIT; CPIPP ANTIBODY; CPIPP ANTIBODY CURCUMIN CONJUGATE; CURCUMIN; MICROSOMAL AMINOPEPTIDASE; PROPIDIUM IODIDE; TRYPAN BLUE; UNCLASSIFIED DRUG;

EID: 58149157482     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000188665     Document Type: Article
Times cited : (25)

References (41)
  • 3
    • 0032998591 scopus 로고    scopus 로고
    • Frequency and clinical significance of beta-subunit human chorionic gonadotropin expression in non-small cell lung cancer patients
    • Szturmowicz M, Slodkowska J, Zych J, Rudzinski P, Sakowicz A, Rowinska-Zakrzewska E: Frequency and clinical significance of beta-subunit human chorionic gonadotropin expression in non-small cell lung cancer patients. Tumor Biol 1999;20:99-104.
    • (1999) Tumor Biol , vol.20 , pp. 99-104
    • Szturmowicz, M.1    Slodkowska, J.2    Zych, J.3    Rudzinski, P.4    Sakowicz, A.5    Rowinska-Zakrzewska, E.6
  • 4
    • 0030033551 scopus 로고    scopus 로고
    • Urinary concentration of human chorionic gonadotropin and its fragments as a prognostic marker in bladder cancer
    • Iles RK, Persad R, Trivedi M, Sharma KB, Dickinson A, Smith P, et al: Urinary concentration of human chorionic gonadotropin and its fragments as a prognostic marker in bladder cancer. Br J Urol 1996;77:61-69.
    • (1996) Br J Urol , vol.77 , pp. 61-69
    • Iles, R.K.1    Persad, R.2    Trivedi, M.3    Sharma, K.B.4    Dickinson, A.5    Smith, P.6
  • 7
    • 0034834188 scopus 로고    scopus 로고
    • Specific staining of human chorionic gonadotropin beta in benign and malignant gastrointestinal tissues with monoclonal antibodies
    • Louhimo J, Nordling S, Alfthan H, von Boguslawski K, Stenman UH, Haglund C: Specific staining of human chorionic gonadotropin beta in benign and malignant gastrointestinal tissues with monoclonal antibodies. Histopathology 2001;38:418-424.
    • (2001) Histopathology , vol.38 , pp. 418-424
    • Louhimo, J.1    Nordling, S.2    Alfthan, H.3    von Boguslawski, K.4    Stenman, U.H.5    Haglund, C.6
  • 8
    • 0026675258 scopus 로고
    • Elevation of free beta subunit of human chorionic gonadotropin and core beta fragment of human chorionic gonadotropin in the serum and urine of patients with malignant pancreatic and biliary diseases
    • Alfthan H, Haglund C, Roberts P, Stenman UH: Elevation of free beta subunit of human chorionic gonadotropin and core beta fragment of human chorionic gonadotropin in the serum and urine of patients with malignant pancreatic and biliary diseases. Cancer Res 1992;52:4628-4633.
    • (1992) Cancer Res , vol.52 , pp. 4628-4633
    • Alfthan, H.1    Haglund, C.2    Roberts, P.3    Stenman, U.H.4
  • 9
    • 0031923081 scopus 로고    scopus 로고
    • Prognostic value of chorionic gonadotropin beta gene transcripts in human breast carcinoma
    • Bièche I, Lazar V, Noguès C, Poynard T, Giovangrandi Y, Bellet D, et al: Prognostic value of chorionic gonadotropin beta gene transcripts in human breast carcinoma. Clin Cancer Res 1998;4:671-676.
    • (1998) Clin Cancer Res , vol.4 , pp. 671-676
    • Bièche, I.1    Lazar, V.2    Noguès, C.3    Poynard, T.4    Giovangrandi, Y.5    Bellet, D.6
  • 10
    • 0031686260 scopus 로고    scopus 로고
    • The prognostic significance of beta human chorionic gonadotropin and its metabolites in women with cervical carcinoma
    • Crawford RA, Iles RK, Carter PG, Caldwell CJ, Shepherd JH, Chard T: The prognostic significance of beta human chorionic gonadotropin and its metabolites in women with cervical carcinoma. J Clin Pathol 1998;51:685-688.
    • (1998) J Clin Pathol , vol.51 , pp. 685-688
    • Crawford, R.A.1    Iles, R.K.2    Carter, P.G.3    Caldwell, C.J.4    Shepherd, J.H.5    Chard, T.6
  • 11
    • 0033595618 scopus 로고    scopus 로고
    • Concentration of free hCGbeta subunit in serum as a prognostic marker for squamous-cell carcinoma of the oral cavity and oropharynx
    • Hedström J, Grenman R, Ramsay H, Finne P, Lundin J, Haglund C, et al: Concentration of free hCGbeta subunit in serum as a prognostic marker for squamous-cell carcinoma of the oral cavity and oropharynx. Int J Cancer 1999;84:525-528.
    • (1999) Int J Cancer , vol.84 , pp. 525-528
    • Hedström, J.1    Grenman, R.2    Ramsay, H.3    Finne, P.4    Lundin, J.5    Haglund, C.6
  • 12
    • 0033558320 scopus 로고    scopus 로고
    • Immunohistochemical study of the expression of human chorionic gonadotropin-beta in oral squamous cell carcinoma
    • Bhalang K, Kafrawy AH, Miles DA: Immunohistochemical study of the expression of human chorionic gonadotropin-beta in oral squamous cell carcinoma. Cancer 1999;85:757-762.
    • (1999) Cancer , vol.85 , pp. 757-762
    • Bhalang, K.1    Kafrawy, A.H.2    Miles, D.A.3
  • 13
    • 0030679560 scopus 로고    scopus 로고
    • Ectopic production of beta-HCG by a maxillary squamous cell carcinoma
    • Scholl, PD, Jurco S, Austin JR: Ectopic production of beta-HCG by a maxillary squamous cell carcinoma. Head Neck 1997;19:701-705.
    • (1997) Head Neck , vol.19 , pp. 701-705
    • Scholl, P.D.1    Jurco, S.2    Austin, J.R.3
  • 14
    • 0030889957 scopus 로고    scopus 로고
    • Rising serum values of beta-subunit human chorionic gonadotropin (hCG) in patients with progressive vulvar carcinomas
    • de Bruijn HW, ten Hoor KA, Krans M, van der Zee AG: Rising serum values of beta-subunit human chorionic gonadotropin (hCG) in patients with progressive vulvar carcinomas. Br J Cancer 1997;75:1217-1218.
    • (1997) Br J Cancer , vol.75 , pp. 1217-1218
    • de Bruijn, H.W.1    ten Hoor, K.A.2    Krans, M.3    van der Zee, A.G.4
  • 15
    • 0028842243 scopus 로고
    • Measurement of urinary beta core fragment of human chorionic gonadotropin in women with vulvo-vaginal malignancy and its prognostic significance
    • Carter PG, Iles RK, Neven P, Ind TE, Shepherd JH, Chard T: Measurement of urinary beta core fragment of human chorionic gonadotropin in women with vulvo-vaginal malignancy and its prognostic significance. Br J Cancer 1995;71:350-353.
    • (1995) Br J Cancer , vol.71 , pp. 350-353
    • Carter, P.G.1    Iles, R.K.2    Neven, P.3    Ind, T.E.4    Shepherd, J.H.5    Chard, T.6
  • 16
  • 17
    • 0642316280 scopus 로고    scopus 로고
    • Expression of beta-human chorionic gonadotropin genes in renal cell cancer and benign renal disease tissues
    • Jiang Y, Zeng F, Xiao C, Liu J: Expression of beta-human chorionic gonadotropin genes in renal cell cancer and benign renal disease tissues. J Huazhong Univ Sci Technol Med Sci 2003;23:291-293.
    • (2003) J Huazhong Univ Sci Technol Med Sci , vol.23 , pp. 291-293
    • Jiang, Y.1    Zeng, F.2    Xiao, C.3    Liu, J.4
  • 18
    • 0037148419 scopus 로고    scopus 로고
    • The free beta-subunit of human chorionic gonadotropin as a prognostic factor in renal cell carcinoma
    • Hotakainen K, Ljungberg B, Paju A, Rasmuson T, Alfthan H, Stenman UH: The free beta-subunit of human chorionic gonadotropin as a prognostic factor in renal cell carcinoma. Br J Cancer 2002;86:185-189.
    • (2002) Br J Cancer , vol.86 , pp. 185-189
    • Hotakainen, K.1    Ljungberg, B.2    Paju, A.3    Rasmuson, T.4    Alfthan, H.5    Stenman, U.H.6
  • 19
    • 0026285513 scopus 로고
    • Ectopic production of beta-subunit of human chorionic gonadotropin in malignant lymphoma
    • Senba M, Watanabe M: Ectopic production of beta-subunit of human chorionic gonadotropin in malignant lymphoma. Zentralbl Pathol 1991;137:402-404.
    • (1991) Zentralbl Pathol , vol.137 , pp. 402-404
    • Senba, M.1    Watanabe, M.2
  • 20
    • 48849097961 scopus 로고    scopus 로고
    • Aberrant expression of beta-hCG in anaplastic large cell lymphoma
    • Leong M, English M, McMullan D, Ramani P: Aberrant expression of beta-hCG in anaplastic large cell lymphoma. Pediatr Dev Pathol 2008;11:230-234.
    • (2008) Pediatr Dev Pathol , vol.11 , pp. 230-234
    • Leong, M.1    English, M.2    McMullan, D.3    Ramani, P.4
  • 23
    • 31644432586 scopus 로고    scopus 로고
    • Human acute lymphoblastic leukemia cells make human pregnancy hormone hCG and expose it on the membrane: A case for using recombinant antibody against hCG for selective delivery of drugs and/or radiations
    • Kabeer RS, Pal R, Talwar GP: Human acute lymphoblastic leukemia cells make human pregnancy hormone hCG and expose it on the membrane: a case for using recombinant antibody against hCG for selective delivery of drugs and/or radiations. Curr Sci 2005;89:1571-1576.
    • (2005) Curr Sci , vol.89 , pp. 1571-1576
    • Kabeer, R.S.1    Pal, R.2    Talwar, G.P.3
  • 24
    • 0017155490 scopus 로고
    • Establishment and characterization of a human histiocytic lymphoma cell line (U-937)
    • Sundstrom C, Nilsson K: Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 1976;17:565-577.
    • (1976) Int J Cancer , vol.17 , pp. 565-577
    • Sundstrom, C.1    Nilsson, K.2
  • 26
    • 0019985877 scopus 로고
    • Properties and characteristics of an anti-hCG monoclonal antibody
    • Gupta SK, Ramakrishnan S, Talwar GP: Properties and characteristics of an anti-hCG monoclonal antibody. J Biosci 1982;4:105-106.
    • (1982) J Biosci , vol.4 , pp. 105-106
    • Gupta, S.K.1    Ramakrishnan, S.2    Talwar, G.P.3
  • 27
    • 0042877336 scopus 로고    scopus 로고
    • Functional recombinant antibodies against hCG expressed in plants
    • Kathuria S, Nath R, Pal R, Singh O, Fischer R, Lohiya NK, et al: Functional recombinant antibodies against hCG expressed in plants. Curr Sci 2002;82:1452-1457.
    • (2002) Curr Sci , vol.82 , pp. 1452-1457
    • Kathuria, S.1    Nath, R.2    Pal, R.3    Singh, O.4    Fischer, R.5    Lohiya, N.K.6
  • 28
    • 0035134241 scopus 로고    scopus 로고
    • A monoclonal antibody cytolytic to androgen independent DU145 and PC3 human prostatic carcinoma cells
    • Talwar GP, Gupta R, Gupta SK, Malhotra R, Khanna R, Mitra DK, et al: A monoclonal antibody cytolytic to androgen independent DU145 and PC3 human prostatic carcinoma cells. Prostate 2001;46:207-213.
    • (2001) Prostate , vol.46 , pp. 207-213
    • Talwar, G.P.1    Gupta, R.2    Gupta, S.K.3    Malhotra, R.4    Khanna, R.5    Mitra, D.K.6
  • 29
    • 0036159184 scopus 로고    scopus 로고
    • Clinically useful monoclonal antibodies in treatment
    • Drewe E, Powell RJ: Clinically useful monoclonal antibodies in treatment. J Clin Pathol 2002;55:81-85.
    • (2002) J Clin Pathol , vol.55 , pp. 81-85
    • Drewe, E.1    Powell, R.J.2
  • 30
    • 34548152541 scopus 로고    scopus 로고
    • Trastuzumab-related cardiotoxicity: Calling into question the concept of reversibility
    • Telli ML, Hunt SA, Carlson RW, Guardino AE: Trastuzumab-related cardiotoxicity: calling into question the concept of reversibility. J Clin Oncol 2007;25:3525-3533.
    • (2007) J Clin Oncol , vol.25 , pp. 3525-3533
    • Telli, M.L.1    Hunt, S.A.2    Carlson, R.W.3    Guardino, A.E.4
  • 31
    • 37549061080 scopus 로고    scopus 로고
    • Complications after oesophagectomy with possible contribution of neoadjuvant therapy including an EGFR-antibody to a fatal outcome
    • Knauer M, Haid A, Ammann K, et al: Complications after oesophagectomy with possible contribution of neoadjuvant therapy including an EGFR-antibody to a fatal outcome. World J Surg Oncol 2007;5:114.
    • (2007) World J Surg Oncol , vol.5 , pp. 114
    • Knauer, M.1    Haid, A.2    Ammann, K.3
  • 32
    • 33751210312 scopus 로고    scopus 로고
    • Ectopic hCGβ expression by epithelial cancer: Malignant behavior, metastasis and inhibition of tumor cell apoptosis
    • Iles RK: Ectopic hCGβ expression by epithelial cancer: malignant behavior, metastasis and inhibition of tumor cell apoptosis. Mol Cell Endocrinol 2007;260-262:264-270.
    • (2007) Mol Cell Endocrinol
    • Iles, R.K.1
  • 34
    • 0015785965 scopus 로고
    • Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent
    • Srimal RC, Dhawan BN: Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol 1973;25:447-452.
    • (1973) J Pharm Pharmacol , vol.25 , pp. 447-452
    • Srimal, R.C.1    Dhawan, B.N.2
  • 36
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions
    • Cheng AL, Hsu CH, Lin JK, et al: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions. Anticancer Res 2001;21:2895-2900.
    • (2001) Anticancer Res , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3
  • 37
    • 15044361086 scopus 로고    scopus 로고
    • Suppression of the nuclear factor-kappa B activation pathway by spice-derived phytochemicals: Reasoning for seasoning
    • Aggarwal BB, Shishodia S: Suppression of the nuclear factor-kappa B activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann NY Acad Sci 2004;1030:434-441.
    • (2004) Ann NY Acad Sci , vol.1030 , pp. 434-441
    • Aggarwal, B.B.1    Shishodia, S.2
  • 38
    • 30044446136 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of I kappa B alpha kinase and Akt activation
    • Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB: Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of I kappa B alpha kinase and Akt activation. Mol Pharmacol 2006;69:195-206.
    • (2006) Mol Pharmacol , vol.69 , pp. 195-206
    • Aggarwal, S.1    Ichikawa, H.2    Takada, Y.3    Sandur, S.K.4    Shishodia, S.5    Aggarwal, B.B.6
  • 39
    • 0036160713 scopus 로고    scopus 로고
    • Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
    • Ireson CR, Jones DJL, Orr S, et al: Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomarkers Prev 2002;11:105-111.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 105-111
    • Ireson, C.R.1    Jones, D.J.L.2    Orr, S.3
  • 40
    • 34447101356 scopus 로고    scopus 로고
    • Studies on the in vitro absorption of spice principles - curcumin, capsaicin and piperine in rat intestines
    • Suresh D, Srinivasan K: Studies on the in vitro absorption of spice principles - curcumin, capsaicin and piperine in rat intestines. Food Chem Toxicol 2007;45:1437-1442.
    • (2007) Food Chem Toxicol , vol.45 , pp. 1437-1442
    • Suresh, D.1    Srinivasan, K.2
  • 41
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64:353-356.
    • (1998) Planta Med , vol.64 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.