An HPLC method for the determination and pharmacokinetic study of lehmannine in rat plasma

Biomedical Chromatography

Volumn 22, Issue 10, 2008, Pages 1149-1154

  Zhao, Gang ^a   Du, Wei ^a   Wei, Yuhui ^a   Qin, Hongyan ^a   Wu, Xinan ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

HPLC; Lehmannine; Pharmacokinetics study; Rat plasma

Indexed keywords

BODY FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; RATS; SODIUM CHLORIDE;

AQUEOUS LAYER; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; INTERNAL STANDARDS; LEHMANNINE; LIQUID CHROMATOGRAPHIC ASSAY; ODS COLUMNS; PERFORMANCE; PHARMACOKINETIC STUDIES; RAT PLASMA;

ACETONITRILE;

ACETONITRILE; ALKALOID; AMMONIUM ACETATE; LEHMANNINE; PHENACETIN; SODIUM CHLORIDE; TRIETHYLAMINE; UNCLASSIFIED DRUG; QUINOLIZIDINE DERIVATIVE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SINGLE DRUG DOSE; ANIMAL; BLOOD; DRUG STABILITY; METHODOLOGY; REPRODUCIBILITY; VALIDATION STUDY; WISTAR RAT;

RATTUS;

ALKALOIDS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; MALE; QUINOLIZIDINES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS;

EID: 58149153186     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1038     Document Type: Article

References (11)

1. Cheng YQ, Chen HL, Li YQ, Chen XG and Hu ZD. Separation and determination of aloperine, sophoridine, matrine and oxymatrine by combination of flow injection with microfluidic capillary electrophoresis. Talanta 2004; 63: 491-496.
2. Cui JB and Wu WH. Pharmacokinetices and bioavailability of lehmannine in rabbits. Chinese Journal of Pharmaceuticals 1991; 22: 257-259.
3. Cui JB, Wu WH and Hu J. A study on the absorption of lehmannine in rat's small intestine. Journal of Shenyang Pharmaceutical University 2007; 24: 86-88.
4. Dan STS, Gao GH, Francis CPL and Paul CHL. Gas chromatography -mass spectrometry determination of matrine in human plasma. Journal of Chromatography B 2004; 808: 209-214.
5. Kinghorn AD and Balandrin MF. Quinolizidine alkaloids of the Leguminosae: structural types, analysis, chemotaxonomy and biological activities. In Alkaloids: Chemical and Biological Perspectives, Vol. 2, Pelletier S-W (ed.). Wiley: New York; 1984; 105-148.
6. Huang XM and Li B. Pharmacological progress on Sophora alopecuraides. Chinese Pharmceutical Affairs 2002; 16: 175-178.
7. Liu B, Li JL and Yuan YJ. Isolation of alkaloids and structure elucidation of lehmannine from seed of Sophora alopecuroides. Chinese Traditional and Herbal Drugs 2001; 32: 294-297.
8. Wu XA, Yamashita F, Hashida M, Chen XG and Hu ZD. Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Talanta 2003; 59: 965-971.
9. Yuan B, Zhou CJ and Wang GQ. The detection of dissociation constants of sophordine and lehmannine by thin layer pH chromatography. Journal of Shenyang Pharmaceutical University 1999; 16: 44-47.
10. Yuan HN. Advances in studies on medicine research. Chinese Journal of Pharmaceutical Analysis 1987; 7: 110-112.
11. Zhong Yao Zhi. Vol. II. Institute of Materia Medica, Chinese Academy of Medical Sciences, People's Health Publishers: Beijing, 1993; 198.