Characterization of a new norfloxacin metabolite monitored during a bioequivalence study by means of mass spectrometry and quantum computation

Biomedical Chromatography

Volumn 22, Issue 10, 2008, Pages 1100-1107

  Medvedovici, Andrei ^a   Sora, Daniela Iuliana ^b   Ionescu, Sorana ^a   Hillebrand, Mihaela ^a   David, Victor ^a  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b LaborMed Pharma SA   (Romania)

Author keywords

Human metabolization; LC APCI MS MS; Liquid chromatography; Metabolite; Norfloxacin; Quantum computation

Indexed keywords

ATMOSPHERIC PRESSURE; BIOMOLECULES; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; METABOLITES; MOLECULES; QUANTUM CHEMISTRY; QUANTUM COMPUTERS;

ANALYTICAL METHOD; BIOEQUIVALENCE STUDY; FLUORESCENCE DETECTION; HUMAN METABOLIZATION; HUMAN SERUM; LC-APCI-MS-MS; LC/APCI-MS/MS; METABOLIZATION; NORFLOXACIN; SERUM SAMPLES;

MASS SPECTROMETRY;

7 AMINOETHYLENAMINO 6 FLUORO 4 HYDROXYQUINOLINE 3 CARBOXYLIC ACID; CIPROFLOXACIN; DRUG METABOLITE; NORFLOXACIN; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; QUANTUM CHEMISTRY; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUNTEER; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PHARMACOKINETICS; QUANTUM THEORY;

CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; NORFLOXACIN; QUANTUM THEORY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 58149148297     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1031     Document Type: Article

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