Inherited protein C deficiency with acute ischemic stroke in a young adult: A case report

Blood Coagulation and Fibrinolysis

Volumn 19, Issue 6, 2008, Pages 601-604

  Yang, Fu Chi ^a   Hsu, Chang Hung ^a   Lin, Jiann Chyun ^a   Chen, Cheng Yu ^a   Lee, Jiunn Tay ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Cerebral ischemia; Coagulation disorder; Protein C

Indexed keywords

NADROPARIN; PROTEIN C; WARFARIN;

ADULT; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; ATAXIC APHASIA; BIOCHEMISTRY; BLOOD PRESSURE MEASUREMENT; BRAIN INFARCTION; CASE REPORT; CELL COUNT; CEREBROVASCULAR ACCIDENT; CHEMOLUMINESCENCE; DOPPLER ECHOCARDIOGRAPHY; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FACIAL NERVE PARALYSIS; FAMILY HISTORY; HEART RATE; HEMIPLEGIA; HETEROZYGOSITY; HUMAN; HYPESTHESIA; IMMUNOASSAY; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; NECROSIS; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN FUNCTION; PROTHROMBIN TIME; RISK FACTOR; SENSORY DYSFUNCTION; ACUTE DISEASE; APHASIA; BLOOD; CEREBRAL ARTERY DISEASE; GENETICS; PEDIGREE;

ACUTE DISEASE; ADULT; APHASIA; HEMIPLEGIA; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; PEDIGREE; PROTEIN C DEFICIENCY;

EID: 58149132614     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e3283009c7c     Document Type: Article

References (24)

1. Hart RG, Miller VT. Cerebral infarction in young adults: a practical approach. Stroke 1983; 14:110-114.
2. Esmon CT. The role of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264:4743-4747.
3. Dahlback B, Villoutreix BO. Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol 2005; 25:1311-1320.
4. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109:3161-3172.
5. Seligsohn U, Berger A, Abend M, Rubin L, Attias D, Zivelin A, et al. Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med 1984; 310:559-562.
6. Kohler J, Kasper J, Witt I, Von Reuthern GM. Ischemic stroke due to protein C deficiency. Stroke 1990; 21:1077-1080.
7. Camerlingo M, Finazzi G, Casto L, Laffranchi C, Barbui T, Mamoli A. Inherited protein C deficiency and nonhaemorrhagic arterial stroke in young adults. Neurology 1991; 41:1371-1373.
8. Matsushita K, Kuriyama Y, Sawada T, Uchida K. Cerebral infarction associated with protein C deficiency. Stroke 1992; 23:108-111.
9. Hart RG, Kanter MC. Hematologic disorders and ischemic stroke: a selective review. Stroke 1990; 21:1111-1121.
10. Born GVR. Aggregation of blood platelets by adenosine diphosphare and its reversal. Nature 1962; 194:927-929.
11. National Committee on Clinical Laboratory Standards. Collection, transport, and processing of blood specimens for testing plasma-based coagulation assay; Vol. 23, No. 35, 4th ed, NCCLS Document H21-A4; 2003.
12. Rubenstein KE, Schneider RS, Ullman EF. 'Homogenous' enzyme immunoassay: a new immunochemical technique. Biochem Biophys Res Commun 1972; 47:846-851.
13. Francis RB Jr, Patch MJ. A functional assay for protein C in human plasma. Thromb Res 1983; 32:605-613.
14. Suzuki K, Nishioka J. Plasma protein S activity using Protac, a snake venom derived activator of protein C. Thromb Res 1988; 49:214-251.
15. Broekmans AW. Hereditary protein C deficiency. Haemostasis 1985; 15:233-240.
16. Smith DB, Ens GE. Protein C deficiency: a cause of amaurosis fugax. J Neurol Neurosurg Psychiatry 1987; 50:361-362.
17. DouayX, Lucas C, Caron C, Goudemand J,Leys D. Antithrombin, protein C and protein S level in 127 consecutive young adults with ischemic stroke. Acta Neurol Scand 1998; 98:124-127.
18. Hoshi S, Hijikata M, Togashi Y, Aoyagi T, Kono C, Yamada Y, et al. Protein C deficiency in a family with thromboembolism and identified gene mutations. Intern Med 2006; 45:997-1003.
19. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68:1370-1373.
20. Velasco F, Andres P, Cañadillas F, Fornes G, Torres A. Transient ischemic attack (T.I.A) in a patient with nonthrombogenic hereditary protein C deficiency under oral contraceptives. Thromb Haemost 1985; 54:904.
21. Dusser A, Neumann CB, Wolf M. Temporary protein C deficiency associated with cerebral arterial thrombosis in childhood. J Pediatr 1988; 113:849-851.
22. Samama M, Horellou MH, Soria J, Conard J, Nicolas G. Successful progressive anticoagulation in a severe protein C deficiency and previous skin necrosis at the initiation of oral anticoagulant treatment. Thromb Haemost 1984; 51:132-133.
23. Jerrard-Dunne P, Evans A, McGovern R, Hajat C, Kaira L, Rudd AG, et al. Ethnic differences in markers of thrombophilia. Implications for the investigation of ischemic stroke in multiethnic populations: The South London Ethnicity and Stroke Study. Stroke 2003; 34:1821-1827.
24. Cheung Y-F, Chay CW, Ma ESK. Ethnic differences in coagulation factor abnormalities after the Fontan procedure. Pediatr Cardiol 2006; 27:96-101.