Excitatory effects of low-level lead exposure on action potential firing of pyramidal neurons in CA1 region of rat hippocampal slices

Journal of Neuroscience Research

Volumn 86, Issue 16, 2008, Pages 3665-3673

  Yan, Dan ^a   Xiao, Cheng ^a   Ma, Fang Li ^b   Wang, Lang ^a   Luo, Yun Yun ^a   Liu, Jin ^a   Wang, Hui Li ^a   Chen, Ju Tao ^a   Ruan, Di Yun ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b Nanfang Lee Kum Kee Co Ltd   (China)

Author keywords

Hippocampal slice; Spike frequency adaptation; Voltage dependent calcium channel

Indexed keywords

CALCIUM; CALCIUM CHANNEL T TYPE; DANTROLENE; LEAD; MIBEFRADIL; OMEGA CONOTOXIN; THAPSIGARGIN; VERAPAMIL;

AMPLITUDE MODULATION; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM TRANSPORT; CONTROLLED STUDY; HIPPOCAMPUS; LEAD POISONING; MALE; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NEUROTOXICITY; NONHUMAN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; RAT;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; HAZARDOUS SUBSTANCES; HIPPOCAMPUS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; LEAD; LEAD POISONING, NERVOUS SYSTEM; MALE; MIBEFRADIL; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 58149114353     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21804     Document Type: Article

References (36)

1. Aldrich RW Jr, Getting PA, Thompson SH. 1979. Mechanism of frequency-dependent broadening of molluscan neurone soma spikes. J Physiol 291:531-544.
2. Altmann L, Lohmann H, Wiegand H. 1988. Acute lead exposure transiently inhibits hippocampal neuronal activities in vitro. Brain Res 455:254-261.
3. Altmann L, Sveinsson K, Wiegand H. 1991. Long-term potentiation in rat hippocampal slices is impaired following acute lead perfusion. Neurosci Lett 128:124-130.
4. Altmann L, Weinsberg F, Sveinsson K, Lilienthal H, Wiegand H, Winneke G. 1993. Impairment of long-term potentiation and learning following chronic lead exposure. Toxicol Lett 66:105-112.
5. Atchison WD. 2003. Effects of toxic environmental contaminants on voltage-gated calcium channel function: from past to present. J Bioenerg Biomembr 35:507-532.
6. Bellinger D, Leviton A, Waternaux C, Needleman H, Rabinowitz M. 1987. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med 316:1037-1043.
7. Bellinger D, Sloman J, Leviton A, Rabinowitz M, Needleman HL, Waternaux C. 1991. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics 87:219-227.
8. Bellinger DC, Stiles KM, Needleman HL. 1992. Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study. Pediatrics 90:855-861.
9. 2+ channels requires treatment with heavy metal antidotes. J Pharmacol Exp Ther 282:172-180.
10. Braga MF, Pereira EF, Albuquerque EX. 1999a. Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res 826:22-34.
11. Braga MF, Pereira EF, Marchioro M, Albuquerque EX. 1999b. Lead increases tetrodotoxin-insensitive spontaneous release of glutamate and GABA from hippocampal neurons. Brain Res 826:10-21.
12. Bressler J, Kim KA, Chakraborti T, Goldstein G. 1999. Molecular mechanisms of lead neurotoxicity. Neurochem Res 24:595-600.
13. Büsselberg D, Evans ML, Rahmann H, Carpenter DO. 1991. Lead and zinc block a voltage-activated calcium channel of Aplysia neurons. J Neurophysiol 65:786-795.
14. 3+. J Neurophysiol 71:1491-1497.
15. Cory-Slechta DA. 1995. Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions. Annu Rev Pharmacol Toxicol 35:391-415.
16. Dai X, Ruan D, Chen J, Wang M, Cai L. 2001. The effects of lead on transient outward currents of acutely dissociated rat dorsal root ganglia. Brain Res 904:327-340.
17. Finkelstein Y, Markowitz ME, Rosen JF. 1998. Low-level lead-induced neurotoxicity in children: an update on central nervous system effects. Brain Res Brain Res Rev 27:168-176.
18. 2+ from calcium pool in dissociated mouse hippocampal neurons]. Wei Sheng Yan Jiu 34:400-402.
19. Gavaghan H. 2002. Lead, unsafe at any level. Bull WHO 80:82.
20. Gong Z, Evans HL. 1997. Effect of chelation with meso-dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat. Toxicol Appl Pharmacol 144:205-214.
21. Gu Y, Wang L, Xiao C, Guo F, Ruan DY. 2005. Effects of lead on voltage-gated sodium channels in rat hippocampal CA1 neurons. Neuroscience 133:679-690.
22. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85-100.
23. Holtzman D, Olson JE, DeVries C, Bensch K. 1987. Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons. Toxicol Appl Pharmacol 89:211-225.
24. Kandel ER, Spencer WA. 1961. Electrophysiology of hippocampal neurons. II. After-potentials and repetitive firing. J Neurophysiol 24:243-259.
25. Lai CC, Lin HH, Chen CW, Chen SH, Chiu TH. 2002. Excitatory action of lead on rat sympathetic preganglionic neurons in vitro and in vivo. Life Sci 71:1035-1045.
26. Levin ED, Bowman RE. 1983. The effect of pre- or postnatal lead exposure on Hamilton search task in monkeys. Neurobehav Toxicol Teratol 5:391-394.
27. Lidsky TI, Schneider JS. 2003. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5-19.
28. + currents in frequency-dependent spike broadening in Aplysia R20 neurons: a dynamic-clamp analysis. J Neurosci 16:4089-4101.
29. Marchetti C. 2003. Molecular targets of lead in brain neurotoxicity. Neurotox Res 5:221-236.
30. Markovac J, Goldstein GW. 1988. Picomolar concentrations of lead stimulate brain protein kinase C. Nature 334:71-73.
31. 2+ permeation in rat cerebellar granule neurones. J Neurochem 79:407-416.
32. 2+ channels transiently expressed in human embryonic kidney 293 cells. Mol Pharmacol 62:1418-1430.
33. Powers RK, Sawczuk A, Musick JR, Binder MD. 1999. Multiple mechanisms of spike-frequency adaptation in motoneurones. J Physiol (Paris) 93:101-114.
34. Rekling JC, Champagnat J, Denavit-Saubie M. 1996. Electroresponsive properties and membrane potential trajectories of three types of inspiratory neurons in the newborn mouse brain stem in vitro. J Neurophysiol 75:795-810.
35. 19FNMR study of NG108-15 cells. Brain Res 503:308-311.
36. Sierra EM, Tiffany-Castiglioni E. 1991. Reduction of glutamine synthetase activity in astroglia exposed in culture to low levels of inorganic lead. Toxicology 65:295-304.