Rapid reduction of liver steatosis in ω3-depleted rats injected with a novel lipid emulsion

Hormone and Metabolic Research

Volumn 40, Issue 12, 2008, Pages 875-879

  Carpentier, Y A ^a   Peltier, S ^b   Portois, L ^a   Sebedio, J L ^c   Leverve, X ^b   Malaisse, W J ^a,d  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b INSERM   (France)

^c CEMAGREF   (France)

^d UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Liver steatosis; Medium chain triglyceride: fish oil emulsion; Rats depleted in long chain polyunsaturated 3 fatty acids

Indexed keywords

FISH OIL; LIPID EMULSION; MEDIUM CHAIN TRIACYLGLYCEROL; OLIVE OIL; OMEGA 3 FATTY ACID; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FATTY LIVER; LIPID LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; FAT EMULSIONS, INTRAVENOUS; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FATTY LIVER; FISH OILS; LIVER; MALE; PHOSPHOLIPIDS; PLANT OILS; RATS; TRIGLYCERIDES;

RATTUS;

EID: 58149107263     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1083781     Document Type: Article

References (17)

1. Simopoulos A. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002; 56: 365-379
2. Seo T, Blaner WS, Deckelbaum RJ. Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr Opin Lipidol 2005; 16: 11-18
3. Billman GE, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs. Circulation 1999; 99: 2452-2457
4. Schrepf R, Limmert T, Weber PC, Theisen K, Sellmayer A. Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia. Lancet 2004; 363: 1441-1442
5. Portois L, Deckelbaum RJ, Malaisse WJ, Carpentier YA. Accumulation rapide d'eicosapentaénoate dans les phospholipides cellulaires après injection intraveineuse d'une émulsion d'huile de poisson et de triglycérides à chaîne moyenne à des sujets normaux. Nutr Clin Metab 2004; 28 (suppl. 1): S53
6. Peltier S, Malaisse WJ, Portois L, Demaison L, Novel-Chate V, Chardigny JM, Sebedio JL, Carpentier YA, Leverve XM. Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3 depleted rats. Int J Mol Med 2006; 18: 471-749
7. Oguzhan B, Zhang Y, Louchami K, Courtois P, Portois L, Chardigny J-M, Malaisse WJ, Carpentier YA, Sener A. Pancreatic islet function in ω3 fatty acid-depleted rats. Glucose metabolism and nutrient-stimulated insulin release. Endocrine 2006; 20: 467-476
8. Richelle M, Carpentier YA, Deckelbaum RJ. Long- and medium-chain triacylglycerols in neutral lipid-exchange process with human plasma low-density lipoproteins. Biochemistry 1994; 33: 4872-4878
9. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids in animal tissues. J Biol Chem 1957; 226: 497-509
10. Dahlan W, Richelle M, Kulapongse S, Rössle C, Deckelbaum RJ, Carpentier YA. Effects of essential fatty acid content of lipid emulsions on erythrocyte polyunsaturated fatty acid composition in patients on long-term parenteral nutrition. Clin Nutr 1992; 11: 262-268
11. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one step reaction. J Lipid Res 1986; 27: 114-120
12. Leyton J, Drury PJ, Crawford MA. Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat. Br J Nutr 1987; 57: 383-393
13. Carpentier YA, Peltier S, Portois L, Chardigny J-M, Sebedio J-L, Leverve X, Malaisse WJ. Accelerated clearance of plasma triglycerides and free fatty acids in ω3-depleted rats. Horm Metab Res 2007; 39: 295-305
14. Oguzhan B, Sancho V, Acitores A, Villanueva-Peñacarrillo M-L, Portois L, Chardigny J-M, Sener A, Carpentier YA, Malaisse WJ. Alteration of adipocyte metabolism in ω3 fatty acid-depleted rats. Horm Metab Res 2006; 38: 789-798
15. Benatti P, Peluso G, Nicolai R, Calvani M. Polyunsaturated fatty acids: biochemical, nutritional and epigenetic properties. J Am Coll Nutr 2004; 23: 281-302
16. Davidson MH. Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol 2006; 98: 27i-33i
17. Portois L, Agascioglu E, Zhang Y, Sener A, Chardigny J-M, Malaisse WJ, Carpentier YA. Rapid effects of the intravenous injection of a medium-chain triglyceride-fish oil emulsion on the triglyceride fatty acid pattern of soleus muscle from ω3 fatty acid-depleted rats. Horm Metab Res 2007; 39: 202-206