Differential diagnosis of primary versus metastatic pulmonary adenocarcinomas using gene mutation analyses: A case report

Journal of Thoracic Oncology

Volumn 3, Issue 8, 2008, Pages 931-934

  Nakazato, Yoshimasa ^a   Tanaka, Ryota ^a   Seki, Erina ^a   Iijima, Misa ^a   Kojima, Masaru ^a   Yoshizumi, Masakazu ^b   Kato, Masahiko ^b   Kimura, Hirokazu ^c   Kozawa, Kunihisa ^b   Goya, Tomoyuki ^d  

^a GUNMA PREFECTURAL CANCER CENTER   (Japan)

^b GUNMA PREFECTURAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d KYORIN UNIVERSITY   (Japan)

Author keywords

Differential diagnosis; Gene mutation; Metastasis; Multiple lung tumor; P53

Indexed keywords

DNA; PROTEIN P53;

ADULT; ARTICLE; BREAST CANCER; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DNA DETERMINATION; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JAPANESE; LUNG ADENOCARCINOMA; LUNG METASTASIS; LUNG RESECTION; MASTECTOMY; MUTATIONAL ANALYSIS; PRIMARY TUMOR; PRIORITY JOURNAL; SAMPLING; TUMOR DIFFERENTIATION; ADENOCARCINOMA; BREAST TUMOR; GENETICS; LUNG TUMOR; LYMPH NODE; METASTASIS; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; RADIOGRAPHY; THYROIDECTOMY;

ADENOCARCINOMA; BREAST NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPH NODES; MASTECTOMY, RADICAL; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; THYROIDECTOMY; TOMOGRAPHY, X-RAY COMPUTED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58149106246     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181802730     Document Type: Article

References (10)

1. Noguchi M, Maezawa N, Nakanishi Y, Matsuno Y, Shimosato Y, Hirohashi S. Application of the p53 gene mutation pattern for differential diagnosis of primary versus metastatic lung carcinomas. Diagn Mol Pathol 1993;2:29-35.
2. Ferguson MK, DeMeester TR, DesLauriers J, Little AG, Piraux M, Golomb H. Diagnosis and management of synchronous lung cancers. J Thorac Cardiovasc Surg 1985;89:378-385.
3. Noguchi M, Morikawa A, Kawasaki M, et al. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer 1995;75: 2844-2852.
4. Yoshizumi M, Kohno T, Nishioka M, Sawada T, Yokota J. Gene Specific-Primer Extension Preamplification (GS-PEP), a simple method to increase the copy number of a gene prior to PCR amplification. Proc Jpn Acad Ser B 2002;78:123-128.
5. Chiba I, Takahashi T, Nau MM, et al. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group. Oncogene 1990;5:1603-1610.
6. Oda T, Tsuda H, Scarpa A, Sakamoto M, Hirohashi S. Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. Cancer Res 1992;52:3674-3678.
7. Mok CH, Tsao SW, Knapp RC, Fishbaugh PM, Lau CC. Unifocal origin of advanced human epithelial ovarian cancers. Cancer Res 1992;52: 5119-5122.
8. Habuchi T, Takahashi R, Yamada H, Kakehi Y, Sugiyama T, Yoshida O. Metachronous multifocal development of urothelial cancers by in-traluminal seeding. Lancet 1993;342:1087-1088.
9. Gasparotto D, Maestro R, Barzan L, et al. Recurrences and second primary tumours in the head and neck region: differentiation by p53 mutation analysis. Ann Oncol 1995;6:933-939.
10. Reichel MB, Ohgaki H, Petersen I, Kleihues P. p53 mutations in primary human lung tumors and their metastases. Mol Carcinog 1994;9: 105-109.