Gastroesophageal reflux disease and obesity

Reviews in Gastroenterological Disorders

Volumn 8, Issue 4, 2008, Pages 233-239

  Anand, Girish ^a   Katz, Philip O ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

Author keywords

Barrett's esophagus; Body mass index; Gastroesophageal reflux disease; Lower esophageal sphincter; Obesity

Indexed keywords

ESOMEPRAZOLE; PROTON PUMP INHIBITOR;

ANTIREFLUX OPERATION; BODY WEIGHT; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE ASSOCIATION; DISEASE SEVERITY; ESOPHAGEAL ADENOCARCINOMA; GASTROESOPHAGEAL REFLUX; HIATUS HERNIA; HUMAN; LIFESTYLE MODIFICATION; OBESITY; PHYSICIAN; PRACTICE GUIDELINE; REFLUX ESOPHAGITIS; REVIEW; RISK FACTOR; SCREENING TEST; WEIGHT REDUCTION;

GASTROESOPHAGEAL REFLUX; HUMANS; OBESITY; WEIGHT LOSS;

EID: 58149090631     PISSN: 1533001X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002;288:1723-1727.
2. Wildi SM, Tutuian R, Castell DO. The influence of rapid food intake on postprandial reflux: studies in healthy volunteers. Am J Gastroenterol. 2004;99:1645-1651.
3. O'Brien TF Jr. Lower esophageal sphincter pressure (LESP) and esophageal function in obese humans. J Clin Gastroenterol. 1980;2:145-148.
4. Stene-Larsen G, Weberg R, Froyshov Larsen I, et al. Relationship of overweight to hiatus hernia and reflux oesophagitis. Scand J Gastroenterol. 1988;23:427-432.
5. Wilson LJ, Ma W, Hirschowitz B. Association of obesity with hiatal hernia and esophagitis. Am J Gastroenterol. 1999;94:2840-2844.
6. Wu JC, Mui LM, Cheung CM, et al. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology. 2007;132:883-889.
7. Pandolfino JE, El-Serag HB, Zhang Q, et al. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology. 2006;130:639-649.
8. Sugerman HJ, DeMaria EJ, Felton WL III, et al. Increased intra-abdominal pressure and cardiac filling pressures in obesity-associated pseudotumor cerebri. Neurology. 1997;49:507-511.
9. Wisen O, Johansson C. Gastrointestinal function in obesity: motility, secretion, and absorption following a liquid test meal. Metabolism. 1992;41:390-395.
10. Harter RL, Kelly WB, Kramer MG, et al. A comparison of the volume and pH of gastric contents of obese and lean surgical patients. Anesth Analg. 1998;86:147-152.
11. Wisen O, Rossner S, Johansson C. Gastric secretion in massive obesity. Evidence of abnormal response to vagal stimulation. Dig Dis Sci. 1987;32:968-972.
12. El-Serag HB, Ergun GA, Pandolfino J, et al. Obesity increases esophageal acid exposure. Gut. 2007;56:749-755. Epub 2006 Nov 24.
13. Mercer CD, Wren SF, DaCosta LR, Beck IT. Lower esophageal sphincter pressure and gastroesophageal pressure gradients in excessively obese patients. J Med. 1987;18:135-146.
14. Kendrick ML, Houghton SG. Gastroesophageal reflux disease in obese patients: the role of obesity in management. Dis Esophagus. 2006;19:57-63.
15. Lagergren J, Bergstrom R, Nyren O. No relation between body mass and gastroesophageal reflux symptoms in a Swedish population based study. Gut. 2000;47:26-29.
16. Corley DA, Kubo A. Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Gastroenterol. 2006;101:2619-2628.
17. Jacobson BC, Somers SC, Fuchs CS, et al. Bodymass index and symptoms of gastroesophageal reflux in women. N Engl J Med. 2006;354:2340-2348.
18. Locke GR, Talley NJ, Fett SL, et al. Risk factors associated with symptoms of gastroesophageal reflux. Am J Med. 1999;106:642-649.
19. Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;143:199-211.
20. Ruhl CE, Everhart JE. Overweight, but not high dietary fat intake, increases risk of gastroesophageal reflux disease hospitalization: the NHANES I Epidemiologic follow up study. First National Health and Nutrition Examination Survey. Ann Epidemiol. 1999;9:424-435.
21. Nandurkar S, Locke GR III, Fett S, et al. Relationship between body mass index, diet, exercise and gastroesophageal reflux symptoms in a community. Aliment Pharmacol Ther. 2004;20:497-505
22. Murray L, Johnston B, Lane A, et al. Relationship between body mass and gastroesophageal reflux symptoms: the Bristol Helicobacter Project. Int J Epidemiol. 2003;32:645-650.
23. Nilsson M, Johnsen R, Ye W, et al. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms. JAMA. 2003;290:66-72.
24. Nocon M, Labenz J, Jaspersen D, et al. Association of body mass index with heartburn, regurgitation, and esophagitis: results of the Progression of Gastroesophageal Reflux Disease study. J Gastroenterol Hepatol. 2007;22:1728-1731.
25. Talley NJ, Howell S, Poulton R. Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study. Am J Gastroenterol. 2004;99:1807-1814.
26. Lundell L, Ruth M, Sandberg N, Bove-Nielsen M. Does massive obesity promote abnormal gastroesophageal reflux? Dig Dis Sci. 1995;40:1632-1635.
27. El-Serag HB, Ergun GA, Pandolfino J, et al. Obesity increases esophageal acid exposure. Gut. 2007;56:749-755.
28. Corley DA, Kubo A, Zhao W. Abdominal obesity, ethnicity, and gastroesophageal reflux symptoms. Gut. 2007;56:756-762.
29. El-Serag HB, Johanson JF. Risk factors for the severity of erosive esophagitis in Helicobacter pylori-negative patients with gastroesophageal reflux disease. Scand J Gastroenterol. 2002;37:899-904.
30. Chang CS, Poon SK, Lien HC, Chen GH. The incidence of reflux esophagitis among the Chinese. Am J Gastroenterol. 1997;92:668-671.
31. Labenz J, Jasperson D, Kulig M, et al. Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative. Am J Gastroenterol. 2004;99:1652-1656.
32. Corley DA, Kubo A, Levin TR, et al. Abdominal obesity and body mass index as risk factors for Barrett's esophagus. Gastroenterology. 2007;133:34-41.
33. Lagergren J, Bergstrom R, Nyren O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med. 1999;130:883-890.
34. Engel LS, Chow WH, Vaughan TL, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst. 2003;95:1404-1413.
35. Pohl H, Robertson D. Obesity - should we worry about esophageal adenocarcinoma [abstract 87]? Am J Gastroenterol. 2004;99:S29.
36. Mathus-Vliegen EMH, van Weeren M, Van Eerten PV. LOS function and obesity: the impact of untreated obesity, weight loss, and chronic gastric balloon distension. Digestion. 2003;68:161-168.
37. Kjellin A, Ramel S, Rossner S, Thor K. Gastroesophageal reflux in obese patients is not reduced by weight reduction. Seand J Gastroenterol. 1996;31:1047-1051.
38. Fraser-Moodie CA, Norton B, Gornall C, et al. Weight loss has an independent beneficial effect on symptoms of gastroesophageal reflux in patients who are overweight. Scand J Gastroenterol. 1999;4:337-340.
39. Jones KB Jr, Allen TV, Manas KJ, et al. Roux-Y gastric bypass: an effective anti-reflux procedure. Obes Surg. 1991;1:295-298.
40. Jones KB Jr. Roux-en-Y gastric bypass: an effective antireflux procedure in the less than morbidly obese. Obes Surg. 1998;8:35-38.
41. Smith SC, Edwards CB, Goodman GN. Symptomatic and clinical improvement in morbidly obese patients with gastroesophageal reflux disease following Roux-en-Y gastric bypass. Obes Surg. 1997;7:479-484.
42. Vakil N, Sharma P, Monyak JT, Silberg DG. Is obesity the cause of reduced healing rates in advanced grades of erosive esophagitis (EE) [abstract 88]? Am J Gastroenterol. 2007;102(suppl 2):S445.
43. Perez AR, Moncure AC, Rattner DW. Obesity adversely affects the outcome of antireflux operations. Surg Endosc. 2002;15:986-989.
44. Fraser J, Watson DI, O'Boyle CJ, Jamieson GG. Obesity and its effect on outcome of laparoscopic Nissen fundoplication. Dis Esophagus. 2001;14:50-53.
45. Peters JH, DeMeester TR, Oberg S, et al. Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg. 1999;3:292-300.
46. Winslow ER, Frisella MM, Soper NJ, Klingensmith ME. Obesity does not adversely affect the outcome of laparoscopic antireflux surgery (LARS). Surg Endosc. 2003;17:2003-2011.