The in vitro anti-denaturation effects induced by natural products and non-steroidal compounds in heat treated (Immunogenic) bovine serum albumin is proposed as a screening assay for the detection of anti-inflammatory compounds, without the use of animals, in the early stages of the drug discovery process

West Indian Medical Journal

Volumn 57, Issue 4, 2008, Pages 327-331

  Williams, Lawrence A D ^a   O'Connar, A ^b   Latore, L ^b   Dennis, O ^b   Ringer, S ^c   Whittaker, J A ^d,f   Conrad, J ^c   Vogler, B ^e   Rosner, H ^c   Kraus, W ^c  

^a Scientific Research Council   (Jamaica)

^b UNIVERSITY OF THE WEST INDIES   (Jamaica)

^c UNIVERSITY OF HOHENHEIM   (Germany)

^d MOREHOUSE SCHOOL OF MEDICINE   (United States)

^e Institute of Bio inorganic Chemistry ^*  (United States)

^f Department of Mathematics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ARTOCARPUS ALTILIS EXTRACT; BOEHMERIA JAMAICENSIS EXTRACT; BOVINE SERUM ALBUMIN; EUGENOL; GLIRICIDA SEPIUM EXTRACT; ISOEUGENOL; NATURAL PRODUCT; PIMENTA DIOICA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ARTOCARPUS ALTILIS; BOEHMERIA JAMAICENSIS; BREADFRUIT; CONTROLLED STUDY; DENATURATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG SCREENING; GLIRICIDA SEPIUM; HEAT TREATMENT; IN VITRO STUDY; LEGUME; PIMENTA; PIMENTA DIOICA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL ASSAY; CATTLE; DRUG DISCOVERY; HOT TEMPERATURE; IMMUNE SYSTEM DISEASES; MASS SCREENING; PLANT PREPARATIONS; PROTEIN DENATURATION; SERUM ALBUMIN, BOVINE;

EID: 58149088999     PISSN: 00433144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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