Diagnostic value of SYT-SSX fusion gene detection by fluorescence in-situ hybridization for synovial sarcoma

Chinese Journal of Pathology

Volumn 37, Issue 10, 2008, Pages 660-664

  Sun, Yan ^a   Sun, Bao Cun ^b   Liu, Yan Xue ^b   Zhang, Shi Wu ^b   Zhao, Xiu Lan ^b   Wang, Jian ^b   Hao, Xi Shan ^b  

^a KEY LABORATORY OF CANCER PREVENTION AND THERAPY   (China)

^b NONE

Author keywords

Gene fusion; In situ hybridization, fluorescence; Sarcoma, synovial

Indexed keywords

ARTICLE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIAL SARCOMA; TISSUE MICROARRAY; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR PATHOLOGY; NUCLEIC ACID HYBRIDIZATION; PROCEDURES; SARCOMA, SYNOVIAL; SOFT TISSUE NEOPLASMS;

HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; NUCLEIC ACID HYBRIDIZATION; ONCOGENE PROTEINS, FUSION; PATHOLOGY, MOLECULAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; SOFT TISSUE NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

ONCOPROTEIN; SYT-SSX FUSION PROTEIN; TUMOR MARKER;

EID: 58049219724     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Fletcher CD, Unni KK, Mertens F. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon:IARC Press, 2002: 10-11.
2. dos Santos NR, de Bruijn DR, van Kessel AG. Molecular mechanisms underlying human synovial sarcoma development. Genes Chromosomes Cancer, 2001, 30(1): 1-14.
3. Guillou L, Coindre J, Gallagher G, et al. Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Hum Pathol, 2001, 32(1): 105-112.
4. Chinese source
5. Chinese source
6. Amary MF, Berisha F, Bernardi Fdel C, et al. Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma. Mod Pathol, 2007, 20(4): 482-496.
7. Terry J, Barry TS, Horsman DE, et al. Fluorescence in situ hybridization for the detection of t(X;18) (p11.2;q11.2) in a synovial sarcoma tissue microarray using a breakapart-style probe. Diagn Mol Pathol, 2005, 14(2): 77-82.
8. van de Rijn M, Barr FG, Collins MH, et al. Absence of SYT-SSX fusion products in soft tissue tumors other than synovial sarcoma. Am J Clin Pathol, 1999, 112(1): 43-49.
9. Chinese source
10. Nocito A, Kononen J, Kallioniemi OP, et al. Tissue microarrays (TMAs) for high-throughput molecular pathology research. Int J Cancer, 2001, 94(1): 1-5.
11. Friedrichs N, Kriegl L, Poremba C, et al. Pitfalls in the detection of t(11;22) translocation by fluorescence in situ hybridization and RT-PCR: a single-blinded study. Diagn Mol Pathol, 2006, 15(2): 83-89.