Severe sepsis in autologous stem cell transplant recipients: Microbiological aetiology, risk factors and outcome

Scandinavian Journal of Infectious Diseases

Volumn 41, Issue 1, 2009, Pages 14-20

  Hämäläinen, Sari ^a   Kuittinen, T ^a   Matinlauri, I ^a   Nousiainen, T ^a   Koivula, I ^a   Jantunen, E ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN B DEOXYCHOLATE; BETA LACTAM ANTIBIOTIC; C REACTIVE PROTEIN; CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; FLUCONAZOLE; MELPHALAN; VANCOMYCIN;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BACTEREMIA; BLOOD CULTURE; CANCER REGRESSION; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG MEGADOSE; FEBRILE NEUTROPENIA; FEMALE; HUMAN; INFECTION RISK; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; PREDICTION; PROGNOSIS; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SEPSIS;

ADOLESCENT; ADULT; AGED; BACTEREMIA; C-REACTIVE PROTEIN; FEMALE; FINLAND; HUMANS; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; PSEUDOMONAS; PSEUDOMONAS INFECTIONS; RISK FACTORS; SEPSIS; STEM CELL TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS; YOUNG ADULT;

EID: 58049208283     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.1080/00365540802454706     Document Type: Article

References (25)

1. Gratwohl, A. (2007) Activity survey and historical perspective of autologous stem cell transplantation in Europe. Semin Hematol, 44, pp. 220-226.
2. Gratwohl, A., Baldomero, H., Frauendorfer, K., Rocha, V., Apperley, J. and Niederwieser, D. (2008) Joint Accreditation Committee of the International Society for Cellular Therapy ISCT; European Group for Blood and Marrow Transplantation EBMT. The EBMT activity survey 2006 on haematopoietic stem cell transplantation: Focus on the use of cord blood products. Bone Marrow Transplant, 41, pp. 687-705.
3. Jantunen, E., Itala, M., Lehtinen, T., Kuittinen, O., Koivunen, E. Leppa, S. et al. (2006) Early treatment-related mortality in adult autologous stem cell transplant recipients: A nationwide survey of 1482 transplanted patients. Eur J Haematol, 76, pp. 245-250.
4. Puig, N., de la Rubia, J., Jarque, I., Salavert, M., Montesinos, P. Sanz, J. et al. (2007) A study of incidence and characteristics of infections in 476 patients from a single centre undergoing autologous blood stem cell transplantation. Int J Hematol, 86, pp. 186-192.
5. Ramphal, R. (2004) Changes in the aetiology of bacteraemia in febrile neutropenic patients and the susceptibilities of the currently isolated pathogens. Clin Infect Dis, 39, pp. 25-31.
6. Kanamaru, A. and Tatsumi, Y. (2004) Microbiological data for patients with febrile neutropenia. Clin Infect Dis, 15, pp. 7-10.
7. Centers for Disease Control and Surveillance (2000) Guidelines for preventing opportunistic infections among haematopoietic stem cell recipients: Recommendations of the CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow transplantation. MMWR Morb Mortal Wkly Rev, 49, pp. 1-125.
8. Hughes, WT, Armstrong, D., Bodey, GP, Bow, EJ, Brown, AE Calandra, T. et al. (2002) Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis, 34, pp. 730-751.
9. Sepkowitz, KA. (2002) Antibiotic prophylaxis in patients receiving haematopoietic stem cell transplant. Bone Marrow Transplant, 29, pp. 367-371.
10. Lo, N. and Cullen, M. (2006) Antibiotic prophylaxis in chemotherapy-induced neutropenia: Time to reconsider. Hematol Oncol, 24, pp. 120-125.
11. Hamalainen, S., Kuittinen, T., Matinlauri, I., Koivula, I., Nousiainen, T. and Jantunen, E. (2008) Neutropenic fever and severe sepsis in adult AML patients receiving intensive chemotherapy: Causes and consequences. Leuk Lymphoma, 49, pp. 495-501.
12. Levy, MM, Fink, MP, Marshall, JC, Abraham, E., Angus, D. Cook, D. et al. (2003) SCCM/ESICM/ACCP/ATS/SIS International Sepsis definitions conference. Crit Care Med, 31, pp. 1250-1256.
13. Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med, 20, pp. 864-874.
14. Otsuji, S., Shibata, H. and Umeda, M. (1982) Turbidimetric immunoassay of serum C-reactive protein. Clin Chem, 28, pp. 2121-2124.
15. Sigurdardottir, K., Digranes, A., Harthug, S., Nesthus, I., Tangen, J-M Dybdahl, B. et al. (2005) A multicentre prospective study of febrile neutropenia in Norway: Microbiological findings and antimicrobial susceptibility. Scand J of Infect Dis, 37, pp. 455-464.
16. Slavin, MA, Grigg, AP, Schwarer, AP, Szer, J., Spencer, A. Sainani, A. et al. (2007) A randomized comparison of empiric or pre-emptive antibiotic therapy after haematopoietic stem cell transplantation. Bone Marrow Transplant, 40, pp. 157-163.
17. Cherif, H., Kronvall, G., Bjorkholm, M. and Kalin, M. (2003) Bacteraemia in hospitalized patients with malignant blood disorders: A retrospective study of causative agents and their resistance profiles during a 14-y period without antibacterial prophylaxis. Hematol J, 4, pp. 420-426.
18. Craig, M., Cumpston, AD, Hobbs, GR, De Vetten, MP, Sarwari, AR and Ericson, SG. (2007) The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a haematological malignancy and transplantation unit. Bone Marrow Transplant, 39, pp. 477-482.
19. Leibovici, L., Paul, M., Cullen, M., Bucaneve, G., Grafter-Gvili, A. Fraser, A. et al. (2006) Antibiotic prophylaxis in neutropenic patients. Cancer, 107, pp. 1743-1751.
20. Cordonnier, C., Herbrecht, R., Buzyn, A., Leverger, G., Leclercq, R. Nitenberg, G. et al. (2005) Risk factors for Gram-negative bacterial infections in febrile neutropenia. Haematologica, 90, pp. 1102-1109.
21. Cordonnier, C., Buzyn-Levy, A., Leverger, G., Herbrecht, R., Hunault, M. Leclercq, R. et al. (2003) Epidemiology and risk factors for Gram-positive coccal infections in neutropenia: Toward a more targeted antibiotic strategy. Clin Infect Dis, 36, pp. 149-158.
22. Naeem, N., Reed, MD, Creger, RJ, Youngner, SJ and Lazarus, HM. (2006) Transfer of the haematopoietic stem cell transplant patient to the intensive care unit: Does it really matter?. Bone Marrow Transplant, 37, pp. 119-133.
23. Fujii, K., Aoyama, M., Shinagawa, K., Matsuo, K., Takenaka, K. Ikeda, K. et al. (2002) Risk of neutropenic fever and early infectious complications after autologous peripheral blood stem cell transplantation for malignant diseases. Int J Hematol, 76, pp. 186-191.
24. Kuittinen, T., Husso-Saastamoinen, M., Sipola, P., Vuolteenaho, O., Ala-Kopsala, M. Nousiainen, T. et al. (2005) Very acute cardiac toxicity during BEAC chemotherapy in non-Hodgkin's lymphoma patients undergoing autologous stem cell transplantation. Bone Marrow Transplant, 36, pp. 1077-1082.
25. Karlsson, S., Pettila, V., Tenhunen, J., Lund, V., Hovilehto, S. and Ruokonen E for the Finnsepsis Study Group (2008) Vascular endothelial growth factor in severe sepsis and septic shock. Anesth Analg, 6, pp. 1820-1826.