Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression

Planta Medica

Volumn 74, Issue 15, 2008, Pages 1785-1788

  Kai, Hisahiro ^a   Baba, Masaki ^a   Okuyama, Toru ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cucumis sativus; Cucurbitaceae; Lutein; Melanin; Tyrosinase

Indexed keywords

2,6 BIS(4' HYDROXYPHENYL) 3,7 DIOXABICYCLO[3.3.0]OCTANE; 3 INDOLECARBOXYLIC ACID; ADENOSINE; BETA CAROTENE; CUCUMEGASTIGMANE I; CUCUMEGASTIGMANE II; CUCUMIS SATIVUS EXTRACT; DEHYDROVOMIFOLIOL; INDOLE 3 ALDEHYDE; MONOPHENOL MONOOXYGENASE; PINORESINOL; PLANT EXTRACT; SESAMIN; UNCLASSIFIED DRUG; XANTHOPHYLL;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL VIABILITY; CONTROLLED STUDY; CUCUMBER; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FRUIT; IC 50; MELANOGENESIS; MELANOMA B16; MOUSE; NONHUMAN; PLANT CALYX; PLANT LEAF; PLANT MORPHOLOGY; PLANT ROOT; PLANT STEM; PROTEIN EXPRESSION;

ANIMALS; ANTIOXIDANTS; CUCUMIS SATIVUS; HYPERPIGMENTATION; MELANINS; MELANOMA, EXPERIMENTAL; MICE; MONOPHENOL MONOOXYGENASE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT STEMS; PYRONES; TUMOR CELLS, CULTURED;

BASIDIOMYCOTA; CUCUMIS SATIVUS; CUCURBITACEAE;

EID: 58049207729     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1088338     Document Type: Article

References (15)

1. Maeda K, Fukuda M. Arbutin: Mechanism of its depigmenting action in human melanocyte culture. J Pharmacol Exp Ther 1996; 276: 765-9
2. Mishima Y, Hatta S, Ohyama Y, Inazu M. Induction of melanogenesis suppression: Cellular pharmacology and mode of differential action. Pigment Cell Res 1988; 1: 367-74
3. Shimogaki H, Tanaka Y, Tamai H, Masuda M. In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition. Int J Cosmet Sci 2000; 22: 291-303
4. Hata K, Iwahori Y, Hori K, Okada Y, Okuyama T. Inhibitory effect of some wild plants in Akita on melanin biosynthesis. Nat Med (Tokyo) 2000; 54: 144-7
5. Chuyaku-daijiten, Part 1. Tokyo: Shogakukan Press; 1985: 105-20
6. Kai H, Baba M, Okuyama T. Two new megastigmanes from the leaves of Cucumis sativus. Chem Pharm Bull 2007; 55: 133-6
7. Kai H, Koine T, Baba M, Okuyama T. Pharmacological effects of Daphne genkwa and Chinese medical prescription, "Jyu-So-To". Yakugaku Zasshi 2004; 124: 349-54
8. Ha SK, Koketsu M, Lee K, Choi SY, Park JH, Ishihara H et al. Inhibition of tyrosinase activity by N,N-unsubstituted selenourea derivatives. Biol Pharm Bull 2005; 28: 838-40
9. Ohguchi K, Akao Y, Nozawa Y. Involvement of calpain in melanogenesis of mouse B16 melanoma cells. Mol Cell Biochem 2005; 275: 103-7
10. Hata K, Hori K, Murata J, Takahashi S. Remodeling of actin cytoskeleton in lupeol-induced B16 2F2 cell differentiation. J Biochem 2005; 138: 467-72
11. Pomerantz SH. The tyrosine hydroxylase activity of mammalian tyrosinase. J Biol Chem 1966; 241: 161-8
12. Hwang JH, Lee BM. Inhibitory effects of plant extracts on tyrosinase, L-DOPA oxidation, and melanin synthesis. J Toxicol Environ Health A 2007; 70: 393-407
13. Thein R, Lotan R. Sensitivity of cultured human osteosarcoma and chondrosarcoma cells to retinoic acid. Cancer Res 1982; 42: 4771-5
14. Choi H, Lee J, Shin HJ, Lee BG, Chang I, Hwang JS. Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs. Planta Med 2004; 70: 378-80
15. Matsuda H, Kawaguchi Y, Yamazaki M, Hirata N, Naruto S, Asanuma Y et al. Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents. Biol Pharm Bull 2004; 27: 1611-6