Successful long-term outcome of the first combined heart and kidney transplant in a patient with systemic AL amyloidosis

American Journal of Transplantation

Volumn 9, Issue 1, 2009, Pages 236-240

  Audard, V ^a,b   Matignon, M ^a,b   Weiss, L ^a,b   Remy, P ^a,b   Pardon, A ^a,b   Haioun, C ^a   Belhadj, K ^a   Salomon, L ^a   Hillon, M L ^a   Sahali, D ^a,b   Vermes, E ^a   Lang, P ^a,b   Grimbert, P ^a,b  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

Amyloidosis; Combined heart and kidney transplantation

Indexed keywords

DEXAMETHASONE; DOXORUBICIN; MELPHALAN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; SERUM ALBUMIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; VINCRISTINE;

ADULT; AMYLOID LIGHT CHAIN AMYLOIDOSIS; AMYLOIDOSIS; ANAMNESIS; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CASE REPORT; CLINICAL FEATURE; COMBINED HEART AND KIDNEY TRANSPLANTATION; CREATININE BLOOD LEVEL; DISEASE COURSE; DRUG DOSE REDUCTION; GASTROINTESTINAL HEMORRHAGE; GLOMERULUS FILTRATION RATE; GRAFT REJECTION; GRAFT SURVIVAL; HEART AMYLOIDOSIS; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; HISTOPATHOLOGY; HUMAN; IMMUNOELECTROPHORESIS; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; MALE; MULTIPLE CYCLE TREATMENT; MULTIPLE ORGAN FAILURE; ORTHOTOPIC TRANSPLANTATION; PLASMA CELL DYSCRASIA; PRIORITY JOURNAL; TREATMENT RESPONSE;

AMYLOIDOSIS; HEART TRANSPLANTATION; HUMANS; KIDNEY TRANSPLANTATION; MALE; MELPHALAN; MIDDLE AGED; PREDNISONE; TRANSPLANTATION CONDITIONING; TREATMENT OUTCOME;

EID: 58049198453     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02469.x     Document Type: Article

References (25)

1. Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med 2003 349 : 583 596.
2. Sanchorawala V. Light-chain (AL) amyloidosis: diagnosis and treatment. Clin J Am Soc Nephrol 2006 1 : 1331 1341.
3. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med 1997 337 : 898 909.
4. Dember LM. Amyloidosis-associated kidney disease. J Am Soc Nephrol 2006 17 : 3458 3471.
5. Comenzo RL, Gertz MA. Autologous stem cell transplantation for primary systemic amyloidosis. Blood 2002 99 : 4276 4282.
6. Comenzo RL. Amyloidosis. Curr Treat Options Oncol 2006 7 : 225 236.
7. Dember LM, Sanchorawala V, Seldin DC et al. Effect of dose-intensive intravenous melphalan and autologous blood stem-cell transplantation on al amyloidosis-associated renal disease. Ann Intern Med 2001 134 : 746 753.
8. Skinner M, Sanchorawala V, Seldin DC et al. High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: An 8-year study. Ann Intern Med 2004 140 : 85 93.
9. Jaccard A, Moreau P, Leblond V et al. High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis. N Engl J Med 2007 357 : 1083 1093.
10. Saba N, Sutton D, Ross H et al. High treatment-related mortality in cardiac amyloid patients undergoing autologous stem cell transplant. Bone Marrow Transplant 1999 24 : 853 855.
11. Gertz MA, Lacy MQ, Dispenzieri A et al. Stem cell transplantation for the management of primary systemic amyloidosis. Am J Med 2002 113 : 549 555.
12. Gillmore JD, Goodman HJ, Lachmann HJ et al. Sequential heart and autologous stem cell transplantation for systemic AL amyloidosis. Blood 2006 107 : 1227 1229.
13. Thaunat O, Alyanakian MA, Varnous S et al. Long-term successful outcome of sequential cardiac and allogeneic bone marrow transplantations in severe AL amyloidosis. Bone Marrow Transplant 2005 35 : 419 420.
14. Sack FU, Kristen A, Goldschmidt H et al. Treatment options for severe cardiac amyloidosis: Heart transplantation combined with chemotherapy and stem cell transplantation for patients with AL-amyloidosis and heart and liver transplantation for patients with ATTR-amyloidosis. Eur J Cardiothorac Surg 2008 33 : 257 262.
15. Maurer MS, Raina A, Hesdorffer C et al. Cardiac transplantation using extended-donor criteria organs for systemic amyloidosis complicated by heart failure. Transplantation 2007 83 : 539 545.
16. Leung N, Griffin MD, Dispenzieri A et al. Living donor kidney and autologous stem cell transplantation for primary systemic amyloidosis (AL) with predominant renal involvement. Am J Transplant 2005 5 : 1660 1670.
17. Abraham RS, Katzmann JA, Clark RJ, Bradwell AR, Kyle RA, Gertz MA. Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol 2003 119 : 274 278.
18. Katzmann JA, Clark RJ, Abraham RS et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains. Clin Chem 2002 48 : 1437 1444.
19. Wechalekar AD, Hawkins PN, Gillmore JD. Perspectives in treatment of AL amyloidosis. Br J Haematol 2008 140 : 365 377.
20. Dubrey SW, Burke MM, Khaghani A, Hawkins PN, Yacoub MH, Banner NR. Long term results of heart transplantation in patients with amyloid heart disease. Heart 2001 85 : 202 207.
21. Alloni A, Pellegrini C, Ragni T et al. Heart transplantation in patients with amyloidosis: Single-center experience. Transplant Proc 2004 36 : 643 644.
22. Dubrey SW, Burke MM, Hawkins PN, Banner NR. Cardiac transplantation for amyloid heart disease: The United Kingdom experience. J Heart Lung Transplant 2004 23 : 1142 1153.
23. Kpodonu J, Massad MG, Caines A, Geha AS. Outcome of heart transplantation in patients with amyloid cardiomyopathy. J Heart Lung Transplant 2005 24 : 1763 1765.
24. Mignot A, Bridoux F, Thierry A et al. Successful heart transplantation following melphalan plus dexamethasone therapy in systemic AL amyloidosis. Haematologica 2008 93 : e32 e35.
25. Wechalekar AD, Lachmann HJ, Gillmore JD, Goodman HJB, Offer M, Hawkins PN. The role of renal transplantationin systemic AL amyloidosis. Blood 106, 3497 (Abstract).