Carcinoma of the lower uterine segment: A newly described association with Lynch syndrome

Journal of Clinical Oncology

Volumn 26, Issue 36, 2008, Pages 5965-5971

  Westin, Shannon N ^a   Lacour, Robin A ^a   Urbauer, Diana L ^a   Luthra, Rajyalakshmi ^a   Bodurka, Diane C ^a   Lu, Karen H ^a   Broaddus, Russell R ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1;

ADULT; AGE DISTRIBUTION; ARTICLE; CANCER INVASION; CANCER LOCALIZATION; CANCER RISK; CANCER STAGING; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CARCINOMA; FAMILIAL CANCER; FEMALE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; MEDICAL RECORD; MICROSATELLITE INSTABILITY; PREOPERATIVE PERIOD; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; UTERUS CARCINOMA;

ADENOCARCINOMA; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; UTERINE NEOPLASMS;

EID: 58049193061     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2008.18.6296     Document Type: Article

References (27)

1. Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2008. CA Cancer J Clin 58:71-96, 2008
2. Hendrickson MR, Kempson RL: Uterus and fallopian tubes, in Sternberg SS (ed): Histology for Pathologists. New York, NY, Raven Press, 1992
3. Sorvari TE, Laakso L: Histochemical investigation of epithelial mucosubstances in the uterine isthmus. Obstet Gynecol 36:76-81, 1970
4. Kehoe S: Treatments for gynaecological cancers. Best Pract Res Clin Obstet Gynaecol 20:985-1000, 2006
5. Dabbs DJ, Sturtz K, Zaino RJ: The immunohistochemical discrimination of endometrioid adenocarcinomas. Hum Pathol 27:172-177, 1996
6. McCluggage WG, Sumathi VP, McBride HA, et al: A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol 21:11-15, 2002
7. Ansari-Lari MA, Staebler A, Zaino RJ, et al: Distinction of endocervical and endometrial adenocarcinomas: Immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection. Am J Surg Pathol 28:160-167, 2004
8. McCluggage WG, Jenkins D: P16 immunoreactivity may assist in the distinction between endometrial and endocervical adenocarcinoma. Int J Gynecol Pathol 22:231-235, 2003
9. Staebler A, Sherman ME, Zaino RJ, et al: Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas. Am J Surg Pathol 26:998-1006, 2002
10. Boronow RC, Morrow CP, Creasman WT, et al: Surgical staging in endometrial cancer: Clinicalpathologic findings of a prospective study. Obstet Gynecol 63:825-832, 1984
11. Hachisuga T, Kaku T, Enjoji M: Carcinoma of the lower uterine segment. Clinicopathologic analysis of 12 cases. Int J Gynecol Pathol 8:26-35, 1989
12. Jacques SM, Qureshi F, Ramirez NC, et al: Tumors of the uterine isthmus: Clinicopathologic features and immunohistochemical characterization of p53 expression and hormone receptors. Int J Gynecol Pathol 16:38-44, 1997
13. Masuda K, Yutani C, Akutagawa K, et al: Cytopathological observations in a 27-year-old female patient with endometrioid adenocarcinoma arising in the lower uterine segment of the uterus. Diagn Cytopathol 21:117-121, 1999
14. Hachisuga T, Fukuda K, Iwasaka T, et al: Endometrioid adenocarcinomas of the uterine corpus in women younger than 50 years of age can be divided into two distinct clinical and pathologic entities based on anatomic location. Cancer 92:2578-2584, 2001
15. International Federation of Gynecology and Obstetrics: Announcements: FIGO staging. Gynecol Oncol 35:125-127, 1989
16. Vasen HF, Watson P, Mecklin JP, et al: New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116:1453-1456, 1999
17. Broaddus RR, Lynch HT, Chen LM, et al: Pathologic features of endometrial carcinoma associated with HNPCC: A comparison with sporadic endometrial carcinoma. Cancer 106:87-94, 2006
18. Lu KH, Schorge JO, Rodabaugh KJ, et al: Prospective determination of prevalence of Lynch syndrome in young women with endometrial cancer. J Clin Oncol 25:5158-5164, 2007
19. Haider MA, Patlas M, Jhaveri K, et al: Adenocarcinoma involving the uterine cervix: Magnetic resonance imaging findings in tumours of endometrial, compared with cervical, origin. Can Assoc Radiol J 57:43-48, 2006
20. Seiden MV, Patel D, O'Neill MJ, et al: Case records of the Massachusetts General Hospital: Case 13-2007 - A 46-year-old woman with gynecologic and intestinal cancers. N Engl J Med 356:1760-1769, 2007
21. Goodfellow PJ, Buttin BM, Herzog TJ, et al: Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. Proc Natl Acad Sci U S A 100:5908-5913, 2003
22. Ollikainen M, Abdel-Rahman WM, Moisio AL, et al: Molecular analysis of familial endometrial carcinoma: A manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol 23:4609-4616, 2005
23. Hampel H, Frankel W, Panescu J, et al: Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res 66:7810-7817, 2006
24. Berends MJ, Wu Y, Sijmons RH, et al: Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis. J Clin Oncol 21:4364-4370, 2003
25. Lynch HT, Watson P, Lanspa SJ, et al: Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). Dis Colon Rectum 31:439-444, 1988
26. Brown AK, Madom L, Moore R, et al: The prognostic significance of lower uterine segment involvement in surgically staged endometrial cancer patients with negative nodes. Gynecol Oncol 105:55-58, 2007
27. Phelan C, Montag AG, Rotmensch J, et al: Outcome and management of pathological stage I endometrial carcinoma patients with involvement of the lower uterine segment. Gynecol Oncol 83:513-517, 2001