Novel promoter polymorphism in RUNX2 is associated with serum triglyceride level

Molecules and Cells

Volumn 26, Issue 5, 2008, Pages 459-461

  Shin, Hyoung Doo ^a,b   Jeon, Jae Pil ^c   Park, Byung Lae ^b   Bae, Joon Seol ^b   Nam, Hye Young ^c   Shim, Sung Mi ^c   Park, Kyong Soo ^d   Han, Bok Ghee ^c  

^a Sogang University   (South Korea)

^b SNP Genetics Inc   (South Korea)

^c Korea National Institute of Health   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

Polymorphism; Promoter; RUNX2; Triglyceride; Type 2 diabetes mellitus

Indexed keywords

GUANINE; THYMINE; TRANSCRIPTION FACTOR RUNX2; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BLOOD CHEMISTRY; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; KOREA; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PROMOTER REGION; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; REGRESSION ANALYSIS; SEX CHARACTERISTICS; TRIGLYCERIDES;

EID: 58049126491     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Committee, E. (1997). Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20, 1183-1197.
2. Doecke, J.D., Day, C.J., Stephens, A.S., Carter, S.L., van Daal, A., Kotowicz, M.A., Nicholson, G.C., and Morrison, N.A. (2006). Association of functionally different RUNX2 P2 promoter alleles with BMD. J. Bone Miner. Res. 21, 265-273.
3. Ermakov, S., Malkin, I., Kobyliansky, E., and Livshits, G. (2006). Variation in femoral length is associated with polymorphisms in RUNX2 gene. Bone 38, 199-205.
4. Goseki-Sone, M., Orimo, H., Watanabe, A., Hamatani, R., Yokozeki, M., Ohyama, K., Kuroda, T., Watanabe, H., Miyazaki, H., Shimada, T., et al. (2001). Identification of a novel frameshift mutation (383insT) in the RUNX2 (PEBP2 alpha/CBFA1/AML3) gene in a Japanese patient with cleidocranial dysplasia. J. Bone Miner. Metab. 19, 263-266.
5. Livak, K.J. (1999). Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal. 14, 143-149.
6. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., and Turner, R.C. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419.
7. Min, W.K., Lim, H., Lee, Y.P., Sung, S.K., Kim, B.D., and Kim, S. (2008). Identification of a third haplotype of the sequence linked to the Restorer-of-fertility (Rf) gene and its implications for male-sterility phenotypes in peppers (Capsicum annuum L.). Mol. Cells 25, 20-29.
8. Mundlos, S., Otto, F., Mundlos, C., Mulliken, J.B., Aylsworth, A.S., Albright, S., Lindhout, D., Cole, W.G., Henn, W., Knoll, J.H., et al. (1997). Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89, 773-779.
9. Otto, F., Kanegane, H., and Mundlos, S. (2002). Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Hum. Mutat. 19, 209-216.
10. Stein, G.S., Lian, J. B., van Wijnen, A.J., Stein, J.L., Montecino, M., Javed, A., Zaidi, S.K., Young, D.W., Choi, J.Y., and Pockwinse, S.M. (2004). Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 23, 4315-4329.
11. Terry, A., Kilbey, A., Vaillant, F., Stewart, M., Jenkins, A., Cameron, E., and Neil, J.C. (2004). Conservation and expression of an alternative 3′ exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene 336, 115-125.
12. Vaughan, T., Pasco, J.A., Kotowicz, M.A., Nicholson, G.C., and Morrison, N.A. (2002). Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture. J. Bone Miner. Res. 17, 1527-1534.
13. Young, D.W., Hassan, M.Q., Yang, X.Q., Galindo, M., Javed, A., Zaidi, S.K., Furcinitti, P., Lapointe, D., Montecino, M., Lian, J.B., et al. (2007). Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc. Natl. Acad. Sci. USA 104, 3189-3194.