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Volumn 26, Issue 5, 2008, Pages 490-495

Association analysis of Tissue factor pathway inhibitor polymorphisms and haplotypes with Osteonecrosis of the femoral head in the Korean population

Author keywords

Femoral head; Osteonecrosis; Polymorphism; TFPI; Thrombosis

Indexed keywords

RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR;

EID: 58049100393     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (45)
  • 2
    • 22244432874 scopus 로고    scopus 로고
    • Enhanced tissue factor pathway inhibitor response as a defense mechanism against ongoing local microvascular events of Legg-Calve-Perthes disease
    • Aksoy, M.C., Aksoy, D.Y., Haznedaroglu, I.C., Sayinalp, N., Kirazli, S., and Alpaslan, M. (2005). Enhanced tissue factor pathway inhibitor response as a defense mechanism against ongoing local microvascular events of Legg-Calve-Perthes disease. Pediatr. Hematol. Oncol. 22, 391-399.
    • (2005) Pediatr. Hematol. Oncol , vol.22 , pp. 391-399
    • Aksoy, M.C.1    Aksoy, D.Y.2    Haznedaroglu, I.C.3    Sayinalp, N.4    Kirazli, S.5    Alpaslan, M.6
  • 3
    • 0036335480 scopus 로고    scopus 로고
    • The -33T→C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations
    • Ameziane, N., Seguin, C., Borgel, D., Fumeron, F., Moatti, D., Alhenc-Gelas, M., Grandchamp, B., Aiach, M., Emmerich, J., and de Prost, D. (2002). The -33T→C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations. Thromb. Haemost. 88, 195-199.
    • (2002) Thromb. Haemost , vol.88 , pp. 195-199
    • Ameziane, N.1    Seguin, C.2    Borgel, D.3    Fumeron, F.4    Moatti, D.5    Alhenc-Gelas, M.6    Grandchamp, B.7    Aiach, M.8    Emmerich, J.9    de Prost, D.10
  • 4
    • 41749089852 scopus 로고    scopus 로고
    • Analysis of a T-287C polymorphism in the tissue factor pathway inhibitor gene and identification of a repressor element in the promoter
    • Amini Nekoo, A., and Iles, D. (2008). Analysis of a T-287C polymorphism in the tissue factor pathway inhibitor gene and identification of a repressor element in the promoter. Thromb. Res. 121, 813-819.
    • (2008) Thromb. Res , vol.121 , pp. 813-819
    • Amini Nekoo, A.1    Iles, D.2
  • 5
    • 0035014293 scopus 로고    scopus 로고
    • Analysis of the tissue factor pathway inhibitor gene and antigen levels in relation to venous thrombosis
    • Amini-Nekoo, A., Futers, T.S., Moia, M., Mannucci, P.M., Grant, P.J., and Ariens, R.A. (2001). Analysis of the tissue factor pathway inhibitor gene and antigen levels in relation to venous thrombosis. Br. J. Haematol. 113, 537-543.
    • (2001) Br. J. Haematol , vol.113 , pp. 537-543
    • Amini-Nekoo, A.1    Futers, T.S.2    Moia, M.3    Mannucci, P.M.4    Grant, P.J.5    Ariens, R.A.6
  • 7
    • 0026545007 scopus 로고
    • Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis
    • Atsumi, T., and Kuroki, Y. (1992). Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis. Clin. Orthop. Relat. Res. 277, 22-30.
    • (1992) Clin. Orthop. Relat. Res , vol.277 , pp. 22-30
    • Atsumi, T.1    Kuroki, Y.2
  • 8
    • 4043052344 scopus 로고    scopus 로고
    • Factor V leiden and prothrombin gene mutation: Risk factors for osteonecrosis of the femoral head in adults
    • Bjorkman, A., Svensson, P.J., Hillarp, A., Burtscher, I.M., Runow, A., and Benoni, G. (2004). Factor V leiden and prothrombin gene mutation: risk factors for osteonecrosis of the femoral head in adults. Clin. Orthop. Relat. Res. 425, 168-172.
    • (2004) Clin. Orthop. Relat. Res , vol.425 , pp. 168-172
    • Bjorkman, A.1    Svensson, P.J.2    Hillarp, A.3    Burtscher, I.M.4    Runow, A.5    Benoni, G.6
  • 9
    • 44649121457 scopus 로고    scopus 로고
    • Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population
    • Chang, J.D., Hur, M., Lee, S.S., Yoo, J.H., and Lee, K.M. (2008). Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population. Clin. Orthop. Relat. Res. 466, 1041-1046.
    • (2008) Clin. Orthop. Relat. Res , vol.466 , pp. 1041-1046
    • Chang, J.D.1    Hur, M.2    Lee, S.S.3    Yoo, J.H.4    Lee, K.M.5
  • 10
    • 0022513615 scopus 로고
    • Osteonecrosis of bone. Current concepts as to etiology and pathogenesis
    • Cruess, R.L. (1986). Osteonecrosis of bone. Current concepts as to etiology and pathogenesis. Clin. Orthop. Relat. Res. 208, 30-39.
    • (1986) Clin. Orthop. Relat. Res , vol.208 , pp. 30-39
    • Cruess, R.L.1
  • 11
    • 0017817135 scopus 로고
    • The role of fat embolism in the etiology of corticosteroid- induced avascular necrosis: Clinical and experimental results
    • Fisher, D.E. (1978). The role of fat embolism in the etiology of corticosteroid- induced avascular necrosis: clinical and experimental results. Clin. Orthop. Relat. Res. 130, 68-80.
    • (1978) Clin. Orthop. Relat. Res , vol.130 , pp. 68-80
    • Fisher, D.E.1
  • 12
    • 0024543984 scopus 로고
    • Functional significance of the Kunitz-type inhibitory domains of lipoproteinassociated coagulation inhibitor
    • Girard, T.J., Warren, L.A., Novotny, W.F., Likert, K.M., Brown, S.G., Miletich, J.P., and Broze, G.J., Jr. (1989). Functional significance of the Kunitz-type inhibitory domains of lipoproteinassociated coagulation inhibitor. Nature 338, 518-520.
    • (1989) Nature , vol.338 , pp. 518-520
    • Girard, T.J.1    Warren, L.A.2    Novotny, W.F.3    Likert, K.M.4    Brown, S.G.5    Miletich, J.P.6    Broze Jr., G.J.7
  • 13
    • 0025876388 scopus 로고
    • Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/ exon gene organization and localization of the gene to chromosome 2
    • Girard, T.J., Eddy, R., Wesselschmidt, R.L., MacPhail, L.A., Likert, K.M., Byers, M.G., Shows, T.B., and Broze, G.J., Jr. (1991). Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/ exon gene organization and localization of the gene to chromosome 2. J. Biol. Chem. 266, 5036-5041.
    • (1991) J. Biol. Chem , vol.266 , pp. 5036-5041
    • Girard, T.J.1    Eddy, R.2    Wesselschmidt, R.L.3    MacPhail, L.A.4    Likert, K.M.5    Byers, M.G.6    Shows, T.B.7    Broze Jr., G.J.8
  • 14
    • 0027958585 scopus 로고
    • Familial idiopathic osteonecrosis mediated by familial hypofibrinolysis with high levels of plasminogen activator inhibitor
    • Glueck, C.J., Glueck, H.I., Welch, M., Freiberg, R., Tracy, T., Hamer, T., and Stroop, D. (1994). Familial idiopathic osteonecrosis mediated by familial hypofibrinolysis with high levels of plasminogen activator inhibitor. Thromb. Haemost. 71, 195-198.
    • (1994) Thromb. Haemost , vol.71 , pp. 195-198
    • Glueck, C.J.1    Glueck, H.I.2    Welch, M.3    Freiberg, R.4    Tracy, T.5    Hamer, T.6    Stroop, D.7
  • 15
    • 0028914541 scopus 로고
    • Idiopathic osteonecrosis, hypofibrinolysis, high plasminogen activator inhibitor, high lipoprotein(a), and therapy with Stanozolol
    • Glueck, C.J., Freiberg, R., Glueck, H.I., Tracy, T., Stroop, D., and Wang, Y. (1995). Idiopathic osteonecrosis, hypofibrinolysis, high plasminogen activator inhibitor, high lipoprotein(a), and therapy with Stanozolol. Am. J. Hematol. 48, 213-220.
    • (1995) Am. J. Hematol , vol.48 , pp. 213-220
    • Glueck, C.J.1    Freiberg, R.2    Glueck, H.I.3    Tracy, T.4    Stroop, D.5    Wang, Y.6
  • 16
    • 85119088800 scopus 로고    scopus 로고
    • Glueck, C.J., Brandt, G., Gruppo, R., Crawford, A., Roy, D., Tracy, T., Stroop, D., Wang, P., and Becker, A. (1997a). Resistance to activated protein C and Legg-Perthes disease. Clin. Orthop. Relat. Res. 338, 139-152.
    • Glueck, C.J., Brandt, G., Gruppo, R., Crawford, A., Roy, D., Tracy, T., Stroop, D., Wang, P., and Becker, A. (1997a). Resistance to activated protein C and Legg-Perthes disease. Clin. Orthop. Relat. Res. 338, 139-152.
  • 17
  • 18
    • 85119092835 scopus 로고    scopus 로고
    • Glueck, C.J., Fontaine, R.N., Gruppo, R., Stroop, D., Sieve-Smith, L., Tracy, T., and Wang, P. (1999). The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin. Orthop. Relat. Res. 366, 133-146.
    • Glueck, C.J., Fontaine, R.N., Gruppo, R., Stroop, D., Sieve-Smith, L., Tracy, T., and Wang, P. (1999). The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin. Orthop. Relat. Res. 366, 133-146.
  • 20
    • 0030138634 scopus 로고    scopus 로고
    • Gruppo, R., Glueck, C.J., McMahon, R.E., Bouquot, J., Rabinovich, B.A., Becker, A., Tracy, T., and Wang, P. (1996). The pathophysiology of alveolar osteonecrosis of the jaw: anticardiolipin antibodies, thrombophilia, and hypofibrinolysis. J. Lab. Clin. Med. 127, 481-488.
    • Gruppo, R., Glueck, C.J., McMahon, R.E., Bouquot, J., Rabinovich, B.A., Becker, A., Tracy, T., and Wang, P. (1996). The pathophysiology of alveolar osteonecrosis of the jaw: anticardiolipin antibodies, thrombophilia, and hypofibrinolysis. J. Lab. Clin. Med. 127, 481-488.
  • 21
    • 85119816313 scopus 로고    scopus 로고
    • Gruppo, R., Glueck, C.J., Wall, E., Roy, D., and Wang, P. (1998). Legg-Perthes disease in three siblings, two heterozygous and one homozygous for the factor V Leiden mutation. J. Pediatr. 132, 885-888.
    • Gruppo, R., Glueck, C.J., Wall, E., Roy, D., and Wang, P. (1998). Legg-Perthes disease in three siblings, two heterozygous and one homozygous for the factor V Leiden mutation. J. Pediatr. 132, 885-888.
  • 22
    • 0036761807 scopus 로고    scopus 로고
    • Observation on tissue factor pathway and some other coagulation parameters during the onset of acute cerebrocardiac thrombotic diseases
    • He, M., Wen, Z., He, X., Xiong, S., Liu, F., Xu, J., Li, J., Xie, Q., Jian, Z., Chen, F., et al. (2002). Observation on tissue factor pathway and some other coagulation parameters during the onset of acute cerebrocardiac thrombotic diseases. Thromb. Res. 107, 223-228.
    • (2002) Thromb. Res , vol.107 , pp. 223-228
    • He, M.1    Wen, Z.2    He, X.3    Xiong, S.4    Liu, F.5    Xu, J.6    Li, J.7    Xie, Q.8    Jian, Z.9    Chen, F.10
  • 23
    • 0027457845 scopus 로고
    • Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head
    • Hirota, Y., Hirohata, T., Fukuda, K., Mori, M., Yanagawa, H., Ohno, Y., and Sugioka, Y. (1993). Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am. J. Epidemiol. 137, 530-538.
    • (1993) Am. J. Epidemiol , vol.137 , pp. 530-538
    • Hirota, Y.1    Hirohata, T.2    Fukuda, K.3    Mori, M.4    Yanagawa, H.5    Ohno, Y.6    Sugioka, Y.7
  • 24
    • 34249002087 scopus 로고    scopus 로고
    • Association study of hypoxia inducible factor 1alpha (HIF1alpha) with osteonecrosis of femoral head in a Korean population
    • Hong, J.M., Kim, T.H., Chae, S.C., Koo, K.H., Lee, Y.J., Park, E.K., Choi, J.Y., Ryoo, H. M., and Kim, S.Y. (2007). Association study of hypoxia inducible factor 1alpha (HIF1alpha) with osteonecrosis of femoral head in a Korean population. Osteoarthritis Cartilage 15, 688-694.
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 688-694
    • Hong, J.M.1    Kim, T.H.2    Chae, S.C.3    Koo, K.H.4    Lee, Y.J.5    Park, E.K.6    Choi, J.Y.7    Ryoo, H.M.8    Kim, S.Y.9
  • 25
    • 0022350720 scopus 로고
    • Fat embolism and osteonecrosis
    • Jones, J.P., Jr. (1985). Fat embolism and osteonecrosis. Orthop. Clin. North Am. 16, 595-633.
    • (1985) Orthop. Clin. North Am , vol.16 , pp. 595-633
    • Jones Jr., J.P.1
  • 26
    • 0033030142 scopus 로고    scopus 로고
    • Coagulopathies and osteonecrosis
    • Jones, J.P., Jr. (1999). Coagulopathies and osteonecrosis. Acta Orthop. Belg. 65, 5-8.
    • (1999) Acta Orthop. Belg , vol.65 , pp. 5-8
    • Jones Jr., J.P.1
  • 29
    • 38348999078 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma gene polymorphisms are not associated with osteonecrosis of the femoral head in the Korean population
    • Kim, T.H., Hong, J.M., Park, E.K., and Kim, S.Y. (2007). Peroxisome proliferator-activated receptor-gamma gene polymorphisms are not associated with osteonecrosis of the femoral head in the Korean population. Mol. Cells 24, 388-393.
    • (2007) Mol. Cells , vol.24 , pp. 388-393
    • Kim, T.H.1    Hong, J.M.2    Park, E.K.3    Kim, S.Y.4
  • 30
    • 0031015687 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor: From unknown coagulation inhibitor to major antithrombotic principle
    • Lindahl, A.K. (1997). Tissue factor pathway inhibitor: from unknown coagulation inhibitor to major antithrombotic principle. Cardiovasc. Res. 33, 286-291.
    • (1997) Cardiovasc. Res , vol.33 , pp. 286-291
    • Lindahl, A.K.1
  • 31
    • 32244438720 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor: Structure, biology and involvement in disease
    • Lwaleed, B.A., and Bass, P.S. (2006). Tissue factor pathway inhibitor: structure, biology and involvement in disease. J. Pathol. 208, 327-339.
    • (2006) J. Pathol , vol.208 , pp. 327-339
    • Lwaleed, B.A.1    Bass, P.S.2
  • 32
    • 0032773736 scopus 로고    scopus 로고
    • Increased level of apolipoprotein B/apolipoprotein A1 ratio as a potential risk for osteonecrosis
    • Miyanishi, K., Yamamoto, T., Irisa, T., Noguchi, Y., Sugioka, Y., and Iwamoto, Y. (1999). Increased level of apolipoprotein B/apolipoprotein A1 ratio as a potential risk for osteonecrosis. Ann. Rheum. Dis. 58, 514-516.
    • (1999) Ann. Rheum. Dis , vol.58 , pp. 514-516
    • Miyanishi, K.1    Yamamoto, T.2    Irisa, T.3    Noguchi, Y.4    Sugioka, Y.5    Iwamoto, Y.6
  • 33
    • 0031877879 scopus 로고    scopus 로고
    • C-399T polymorphism in the promoter region of human tissue factor pathway inhibitor (TFPI) gene does not change the plasma TFPI antigen level and does not cause venous thrombosis
    • Miyata, T., Sakata, T., Kumeda, K., Uchida, K., Tsushima, M., Fujimura, H., Kawasaki, T., and Kato, H. (1998). C-399T polymorphism in the promoter region of human tissue factor pathway inhibitor (TFPI) gene does not change the plasma TFPI antigen level and does not cause venous thrombosis. Thromb. Haemost. 80, 345-346.
    • (1998) Thromb. Haemost , vol.80 , pp. 345-346
    • Miyata, T.1    Sakata, T.2    Kumeda, K.3    Uchida, K.4    Tsushima, M.5    Fujimura, H.6    Kawasaki, T.7    Kato, H.8
  • 34
    • 0032892214 scopus 로고    scopus 로고
    • Polymorphisms of the tissue factor pathway inhibitor (TFPI) gene in patients with acute coronary syndromes and in healthy subjects: Impact of the V264M substitution on plasma levels of TFPI
    • Moatti, D., Seknadji, P., Galand, C., Poirier, O., Fumeron, F., Desprez, S., Garbarz, M., Dhermy, D., Arveiler, D., Evans, A., et al. (1999). Polymorphisms of the tissue factor pathway inhibitor (TFPI) gene in patients with acute coronary syndromes and in healthy subjects: impact of the V264M substitution on plasma levels of TFPI. Arterioscler. Thromb. Vasc. Biol. 19, 862-869.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , pp. 862-869
    • Moatti, D.1    Seknadji, P.2    Galand, C.3    Poirier, O.4    Fumeron, F.5    Desprez, S.6    Garbarz, M.7    Dhermy, D.8    Arveiler, D.9    Evans, A.10
  • 35
    • 0033854157 scopus 로고    scopus 로고
    • A new T-287C polymorphism in the 5′ regulatory region of the tissue factor pathway inhibitor gene. Association study of the T-287C and C-399T polymorphisms with coronary artery disease and plasma TFPI levels
    • Moatti, D., Haidar, B., Fumeron, F., Gauci, L., Boudvillain, O., Seknadji, P., Olliver, V., Aumont, M.C., and de Prost, D. (2000). A new T-287C polymorphism in the 5′ regulatory region of the tissue factor pathway inhibitor gene. Association study of the T-287C and C-399T polymorphisms with coronary artery disease and plasma TFPI levels. Thromb. Haemost. 84, 244-249.
    • (2000) Thromb. Haemost , vol.84 , pp. 244-249
    • Moatti, D.1    Haidar, B.2    Fumeron, F.3    Gauci, L.4    Boudvillain, O.5    Seknadji, P.6    Olliver, V.7    Aumont, M.C.8    de Prost, D.9
  • 36
    • 33847626359 scopus 로고    scopus 로고
    • Role of thrombotic and fibrinolytic alterations in the pathogenesis and treatment of osteonecrosis
    • Mont, M.A., Ulrich, S.D., and Seyler, T.M. (2007). Role of thrombotic and fibrinolytic alterations in the pathogenesis and treatment of osteonecrosis. J. Rheumatol. 34, 466-468.
    • (2007) J. Rheumatol , vol.34 , pp. 466-468
    • Mont, M.A.1    Ulrich, S.D.2    Seyler, T.M.3
  • 37
    • 78651141390 scopus 로고
    • Severe thrombotic disease in a young man with bone marrow and skeletal changes and with a high content of an inhibitor in the fibrinolytic system
    • Nilsson, I.M., Krook, H., Sternby, N.H., Soderberg, E., and Soderstrom, N. (1961). Severe thrombotic disease in a young man with bone marrow and skeletal changes and with a high content of an inhibitor in the fibrinolytic system. Acta Med. Scand. 169, 323-337.
    • (1961) Acta Med. Scand , vol.169 , pp. 323-337
    • Nilsson, I.M.1    Krook, H.2    Sternby, N.H.3    Soderberg, E.4    Soderstrom, N.5
  • 38
    • 0036844521 scopus 로고    scopus 로고
    • Partition-ligation-expectation-maximization algorithm for haplotype inference with singlenucleotide polymorphisms
    • Qin, Z.S., Niu, T., and Liu, J.S. (2002). Partition-ligation-expectation-maximization algorithm for haplotype inference with singlenucleotide polymorphisms. Am. J. Hum. Genet. 71, 1242-1247.
    • (2002) Am. J. Hum. Genet , vol.71 , pp. 1242-1247
    • Qin, Z.S.1    Niu, T.2    Liu, J.S.3
  • 39
    • 0029153045 scopus 로고
    • The tissue factor pathway: How it has become a "prima ballerina
    • Rapaport, S.I., and Rao, L.V. (1995). The tissue factor pathway: how it has become a "prima ballerina". Thromb. Haemost. 74, 7-17.
    • (1995) Thromb. Haemost , vol.74 , pp. 7-17
    • Rapaport, S.I.1    Rao, L.V.2
  • 40
    • 0026519049 scopus 로고
    • Early arteriopathy and postulated pathogenesis of osteonecrosis of the femoral head. The intracapital arterioles
    • Saito, S., Ohzono, K., and Ono, K. (1992). Early arteriopathy and postulated pathogenesis of osteonecrosis of the femoral head. The intracapital arterioles. Clin. Orthop. Relat. Res. 277, 98-110.
    • (1992) Clin. Orthop. Relat. Res , vol.277 , pp. 98-110
    • Saito, S.1    Ohzono, K.2    Ono, K.3
  • 41
    • 0027427132 scopus 로고
    • Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip
    • Van Veldhuizen, P.J., Neff, J., Murphey, M.D., Bodensteiner, D., and Skikne, B.S. (1993). Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip. Am. J. Hematol. 44, 243-248.
    • (1993) Am. J. Hematol , vol.44 , pp. 243-248
    • Van Veldhuizen, P.J.1    Neff, J.2    Murphey, M.D.3    Bodensteiner, D.4    Skikne, B.S.5
  • 42
    • 0038066762 scopus 로고    scopus 로고
    • Alcohol-induced adipogenesis in bone and marrow: A possible mechanism for osteonecrosis
    • Wang, Y., Li, Y., Mao, K., Li, J., Cui, Q., and Wang, G.J. (2003). Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin. Orthop. Relat. Res. 410, 213-224.
    • (2003) Clin. Orthop. Relat. Res , vol.410 , pp. 213-224
    • Wang, Y.1    Li, Y.2    Mao, K.3    Li, J.4    Cui, Q.5    Wang, G.J.6
  • 43
    • 0343384365 scopus 로고    scopus 로고
    • Severe protein C deficiency and aseptic osteonecrosis of the hip joint: A case report
    • Wermes, C., Bergmann, F., Reller, B., and Sykora, K.W. (1999). Severe protein C deficiency and aseptic osteonecrosis of the hip joint: a case report. Eur. J. Pediatr. 158(Suppl. 3), S159-161.
    • (1999) Eur. J. Pediatr , vol.158 , Issue.SUPPL. 3
    • Wermes, C.1    Bergmann, F.2    Reller, B.3    Sykora, K.W.4
  • 44
    • 0036007396 scopus 로고    scopus 로고
    • The 677C→T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head
    • Zalavras, C.G., Malizos, K.N., Dokou, E., and Vartholomatos, G. (2002). The 677C→T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head. Haematologica 87, 111-112.
    • (2002) Haematologica , vol.87 , pp. 111-112
    • Zalavras, C.G.1    Malizos, K.N.2    Dokou, E.3    Vartholomatos, G.4
  • 45
    • 2542494950 scopus 로고    scopus 로고
    • Genetic background of osteonecrosis: Associated with thrombophilic mutations?
    • Zalavras, C.G., Vartholomatos, G., Dokou, E., and Malizos, K.N. (2004). Genetic background of osteonecrosis: associated with thrombophilic mutations? Clin. Orthop. Relat. Res. 422, 251-255.
    • (2004) Clin. Orthop. Relat. Res , vol.422 , pp. 251-255
    • Zalavras, C.G.1    Vartholomatos, G.2    Dokou, E.3    Malizos, K.N.4


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