Identification of placental leucine aminopeptidase and triton-slowed aminopeptidase N in serum of pregnant women

Clinica Chimica Acta

Volumn 400, Issue 1-2, 2009, Pages 37-41

  Kawai, Makoto ^a   Araragi, Keiko ^b   Shimizu, Yasufumi ^c   Hara, Yukichi ^c  

^a TOKYO KYOSAI HOSPITAL   (Japan)

^b KYORIN UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Aminopeptidase; Cholestasis; PAGE; Placenta; Triton

Indexed keywords

ARYL ACYLAMIDASE; CYTOSOL AMINOPEPTIDASE; GLYCOSIDASE; MICROSOMAL AMINOPEPTIDASE; TYLOXAPOL;

ARTICLE; BLOOD SAMPLING; ENZYME ACTIVITY; FEMALE; HUMAN; MATERNAL SERUM; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ANTIGENS, CD13; BLOOD CHEMICAL ANALYSIS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; LEUCYL AMINOPEPTIDASE; NEPTUNE; PLACENTA; PREGNANCY; SENSITIVITY AND SPECIFICITY;

ORYCTOLAGUS CUNICULUS;

EID: 57949095085     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2008.10.008     Document Type: Article

References (16)

1. Kawai M., and Hara Y. Triton-polyacrylamide gel electrophoresis and leucine aminopeptidase activity staining detect Triton-slowed bands including high-molecular-mass aminopeptidase N (CD13) isoform in cholestatic patient sera. Clin Chim Acta 364 (2006) 188-195
2. Rogi T., Tsujimoto M., Nakazato H., Mizutani S., and Tomoda Y. Human placental leucine aminopeptidase/oxytocinase. J Biol Chem 271 (1996) 56-61
3. Laustsen P.G., Rasmussen T.E., Petersen K., et al. The complete amino acid sequence of human placental oxytocinase. Biochim Biophys Acta 1352 (1997) 1-7
4. Ikoma Y., Nomura S., Ito T., et al. Interleukin-1β stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells. Mol Hum Reprod 9 (2003) 103-110
5. Look A.T., Ashmun R.A., Shapiro L.H., and Peiper S.C. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J Clin Invest 83 (1989) 1299-1307
6. Shipp M.A., and Look A.T. Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key!. Blood 82 (1993) 1052-1070
7. Reichling J.J., and Kaplan M.M. Clinical use of serum enzymes in liver disease. Dig Dis Sci 33 (1988) 1601-1614
8. Yamahara N., Nomura S., Suzuki T., et al. Placental leucine aminopeptidase/oxytocinase in maternal serum and placenta during normal pregnancy. Life Sci 66 (2000) 1401-1410
9. Deng J.T., Hoylaerts M.F., Nouwen E.J., De Broe M.E., and Van Hoof V.O. Purification of circulating liver plasma membrane fragments using a monoclonal antileucine aminopeptidase antibody. Hepatology 23 (1996) 445-454
10. Favaloro E.J., Browning T., and Nandurkar H. The hepatobiliary disease marker serum alanine aminopeptidase predominantly comprises an isoform of the haematological myeloid differentiation antigen and leukaemia marker CD-13/gp150. Clin Chim Acta 220 (1993) 81-90
11. Sanderink G.J.C.M., Artur Y., Galteau M.M., Wellman-Bednawska M., and Siest G. Multiple forms of serum aminopeptidases separated by micro two-dimensional electrophoresis under non-denaturing conditions. Electrophoresis 7 (1986) 471-475
12. Watanabe Y., Iwaki-Egawa S., Mizukoshi H., and Fujimoto Y. Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N. Biol Chem Hoppe-Seyler 376 (1995) 397-400
13. Matsumoto H., Rogi T., Yamashiro K., et al. Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells. Eur J Biochem 267 (2000) 46-52
14. Kawai M., Otake Y., and Hara Y. High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients. Clin Chim Acta 330 (2003) 141-149
15. Norén K., Hansen G.H., Clausen H., Norén O., Sjöström H., and Vogel L.K. Defectively N-glycosylated and non-O-glycosylated aminopeptidase (CD13) is normally expressed at the cell surface and has full enzymatic activity. Exp Cell Res 231 (1997) 112-118
16. Watanabe Y., Iwaki-Egawa S., Yokosawa J., Mizukoshi H., and Fujimoto Y. An antibody specific to N-terminal amino acid sequence of human maternal serum cystine aminopeptidase and its applications. Biochem Mol Biol Int 38 (1996) 653-658