The growth phase-dependent regulation of the pilus locus genes by two-component system TCS08 in Streptococcus pneumoniae

Microbial Pathogenesis

Volumn 46, Issue 1, 2009, Pages 28-35

  Song, Xin Ming ^a   Connor, Wayne ^a   Hokamp, Karsten ^b   Babiuk, Lorne A ^c   Potter, Andrew A ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Adhesion; Epithelial cells; Invasion; Pilus; Streptococcus pneumoniae; Two component system

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; CELL ADHESION; CELL INVASION; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENETIC CODE; GENETIC TRANSCRIPTION; GROWTH CURVE; HK08 GENE; HUMAN; HUMAN CELL; NASOPHARYNX; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RLRA GENE; RR08 GENE; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

BACTERIAL ADHESION; BACTERIAL PROTEINS; CELL LINE; EPITHELIAL CELLS; FIMBRIAE, BACTERIAL; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; LUNG; NASOPHARYNX; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, BACTERIAL; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; TRANS-ACTIVATORS;

STREPTOCOCCUS PNEUMONIAE;

EID: 57949087585     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2008.10.006     Document Type: Article

References (35)

1. Cutts F.T., Zaman S.M., Enwere G., Jaffar S., Levine O.S., Okoko J.B., et al. Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in the Gambia: randomised, double-blind, placebo-controlled trial. Lancet 365 9465 (2005) 1139-1146
2. Beier D., and Gross R. Regulation of bacterial virulence by two-component systems. Curr Opin Microbiol 9 2 (2006) 143-152
3. Lange R., Wagner C., de Saizieu A., Flint N., Molnos J., Stieger M., et al. Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae. Gene 237 1 (1999) 223-234
4. Throup J.P., Koretke K.K., Bryant A.P., Ingraham K.A., Chalker A.F., Ge Y., et al. A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol Microbiol 35 3 (2000) 566-576
5. Paterson G.K., Blue C.E., and Mitchell T.J. Role of two-component systems in the virulence of Streptococcus pneumoniae. J Med Microbiol 55 Pt. 4 (2006) 355-363
6. Ng W.L., Tsui H.C., and Winkler M.E. Regulation of the pspA virulence factor and essential pcsB murein biosynthetic genes by the phosphorylated VicR (YycF) response regulator in Streptococcus pneumoniae. J Bacteriol 187 21 (2005) 7444-7459
7. Standish A.J., Stroeher U.H., and Paton J.C. The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumoniae. Proc Natl Acad Sci U S A 102 21 (2005) 7701-7706
8. Ma Z., and Zhang J.R. RR06 activates transcription of spr1996 and cbpA in Streptococcus pneumoniae. J Bacteriol 189 6 (2007) 2497-2509
9. Standish A.J., Stroeher U.H., and Paton J.C. The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms. J Bacteriol 189 15 (2007) 5591-5600
10. McCluskey J., Hinds J., Husain S., Witney A., and Mitchell T.J. A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae. Mol Microbiol 51 6 (2004) 1661-1675
11. Sebert M.E., Palmer L.M., Rosenberg M., and Weiser J.N. Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization. Infect Immun 70 8 (2002) 4059-4067
12. McKessar S.J., and Hakenbeck R. The two-component regulatory system TCS08 is involved in cellobiose metabolism of Streptococcus pneumoniae R6. J Bacteriol 189 4 (2007) 1342-1350
13. Hava D.L., Hemsley C.J., and Camilli A. Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA. J Bacteriol 185 2 (2003) 413-421
14. Barocchi M.A., Ries J., Zogaj X., Hemsley C., Albiger B., Kanth A., et al. A pneumococcal pilus influences virulence and host inflammatory responses. Proc Natl Acad Sci U S A 103 8 (2006) 2857-2862
15. Rosch J.W., Mann B., Thornton J., Sublett J., and Tuomanen E. Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae. Infect Immun 76 7 (2008) 3187-3196
16. Scott J.R., and Zahner D. Pili with strong attachments: gram-positive bacteria do it differently. Mol Microbiol 62 2 (2006) 320-330
17. LeMieux J., Hava D.L., Basset A., and Camilli A. RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet. Infect Immun 74 4 (2006) 2453-2456
18. Nelson A.L., Ries J., Bagnoli F., Dahlberg S., Falker S., Rounioja S., et al. RrgA is a pilus-associated adhesin in Streptococcus pneumoniae. Mol Microbiol 66 2 (2007) 329-340
19. Hilleringmann M., Giusti F., Baudner B.C., Masignani V., Covacci A., Rappuoli R., et al. Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A. PLoS Pathog 4 3 (2008) e1000026
20. Gianfaldoni C., Censini S., Hilleringmann M., Moschioni M., Facciotti C., Pansegrau W., et al. Streptococcus pneumoniae pilus subunits protect mice against lethal challenge. Infect Immun 75 2 (2007) 1059-1062
21. Aguiar S.I., Serrano I., Pinto F.R., Melo-Cristino J., and Ramirez M. The presence of the pilus locus is a clonal property among pneumococcal invasive isolates. BMC Microbiol 8 (2008) 41
22. Bagnoli F., Moschioni M., Donati C., Dimitrovska V., Ferlenghi I., Facciotti C., et al. A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol 190 15 (2008) 5480-5492
23. Hemsley C., Joyce E., Hava D.L., Kawale A., and Camilli A. MgrA, an orthologue of Mga, acts as a transcriptional repressor of the genes within the rlrA pathogenicity islet in Streptococcus pneumoniae. J Bacteriol 185 22 (2003) 6640-6647
24. Hendriksen W.T., Silva N., Bootsma H.J., Blue C.E., Paterson G.K., Kerr A.R., et al. Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent. J Bacteriol 189 4 (2007) 1382-1389
25. McIver K.S., and Scott J.R. Role of mga in growth phase regulation of virulence genes of the group A streptococcus. J Bacteriol 179 16 (1997) 5178-5187
26. Ha U., and Jin S. Growth phase-dependent invasion of Pseudomonas aeruginosa and its survival within HeLa cells. Infect Immun 69 7 (2001) 4398-4406
27. Pizarro-Cerda J., and Cossart P. Bacterial adhesion and entry into host cells. Cell 124 4 (2006) 715-727
28. Yebra M.J., Monedero V., Zuniga M., Deutscher J., and Perez-Martinez G. Molecular analysis of the glucose-specific phosphoenolpyruvate: sugar phosphotransferase system from Lactobacillus casei and its links with the control of sugar metabolism. Microbiology 152 Pt. 1 (2006) 95-104
29. Zhang J.R., Idanpaan-Heikkila I., Fischer W., and Tuomanen E.I. Pneumococcal licD2 gene is involved in phosphorylcholine metabolism. Mol Microbiol 31 5 (1999) 1477-1488
30. Song X.M., Connor W., Jalal S., Hokamp K., and Potter A.A. Microarray analysis of Streptococcus pneumoniae gene expression changes to human lung epithelial cells. Can J Microbiol 54 (2008) 189-200
31. Orihuela C.J., Radin J.N., Sublett J.E., Gao G., Kaushal D., and Tuomanen E.I. Microarray analysis of pneumococcal gene expression during invasive disease. Infect Immun 72 10 (2004) 5582-5596
32. Song X.M., Connor W., Hokamp K., Lorne B.A., and Potter A.A. Streptococcus pneumoniae early response genes to human lung epithelial cells. BMC Res Notes 1 (2008) 64
33. Song X.M., Connor W., Hokamp K., Lorne B.A., and Potter A.A. Transcriptome studies on Streptococcus pneumoniae, illustration of early response genes to THP-1 human macrophages. Genomics (2008) 10.1016/j.ygeno.2008.09.008
34. Song X.M., Perez-Casal J., and Potter A.A. The Mig protein of Streptococcus dysgalactiae inhibits bacterial internalization into bovine mammary gland epithelial cells. FEMS Microbiol Lett 231 1 (2004) 33-38
35. Hokamp K., Roche F.M., Acab M., Rousseau M.E., Kuo B., Goode D., et al. ArrayPipe: a flexible processing pipeline for microarray data. Nucleic Acids Res 32 Web Server issue (2004) W457-W459