Characterization of doxorubicin binding site and drug induced alteration in the functionally important structural state of oxyhemoglobin

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 4, 2008, Pages 1096-1104

  Khan, Shahper N ^a   Islam, Barira ^a   Yennamalli, Ragothaman ^b   Zia, Qamar ^a   Subbarao, Naidu ^b   Khan, Asad U ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Binding mode; Doxorubicin; Fluorescence resonance energy transfer (FRET); Hemoglobin; Molecular docking

Indexed keywords

DOXORUBICIN; FREE RADICAL; MANNITOL; OXYHEMOGLOBIN; SUPEROXIDE DISMUTASE;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG PROTEIN BINDING; HUMAN; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; THERMODYNAMICS;

ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; BUFFERS; CIRCULAR DICHROISM; DOXORUBICIN; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXYHEMOGLOBINS; PHOSPHATES; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 57849169341     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.08.030     Document Type: Article

References (55)

1. Scheller F.W., Bistolas N., Liu S.Q., Janchen M., Katterle M., and Wollenberger U. Adv. Colloid Interface Sci. 116 (2005) 111-120
2. Berg J.M., Tymoczko T.L., and Stryer L. Biochemistry. fifth ed. (2002), Freeman, San Francisco 894 pp
3. De Swati A., and Girigoswami J. Colloid Interface Sci. 296 (2006) 324-331
4. Orr R.T., and Von Hoff D.D. Cancer Chemotherapy Handbook. second ed. (1994), Appelton and Lang, Norwalk, CA pp. 396-411
5. Doroshow J.H., Locker G.Y., Ifrim I., and Myers C.E. J. Clin. Invest. 68 (1981) 1053-1064
6. Huang B., Zou G.L., Jin D.L., and Li H.C. Shanghai 35 (2003) 301-305
7. Lown J.W., Sim S., Majumdar K.C., and Chang R. Biochem. Biophys. Res. Commun. 76 (1977) 705-710
8. Muindi J.R., Sinha B.K., Gianni L., and Myers C.E. FEBS Lett. 172 (1984) 226-230
9. Goodman J., and Hochstein P. Biophys. Res. Commun. 7 (1977) 797-803
10. Shinohara K., and Tanaka K.R. Hemoglobin 4 (1980) 735-745
11. Henderson C.A., Metz E.N., Balcerzak S.P., and Sagone A.L. Blood 52 (1978) 878-885
12. Sagone A.L. Am. J. Hematol. 7 (1979) 97-106
13. Winterbourn C.C., French J.K., and Claridge R.F.C. Biochem. J. 179 (1979) 665-673
14. Ramanathan-Girish S., and Boroujerdi M. J. Pharm. Pharmacol. 53 (2001) 815-821
15. Dalmark M., and Johansen P. Mol. Pharmacol. 22 (1982) 158-165
16. Myers C.E., Gianni L., Simone C.B., Klecker R., and Greene R. Biochemistry 21 (1982) 1707-1713
17. Gutteridge J.M. Biochem. Pharmacol. 33 (1984) 1725-1728
18. Khan S.N., Islam B., and Khan A.U. Int. J. Integ. Biol. 2 (2007) 102-112
19. Karnaukhova E. Biochem. Pharmacol. 73 (2007) 901-910
20. Motterlini R., Foresti R., Vandegriff K., Intaglietta M., and Winslow R.M. Am. J. Physiol. 269 (1995) H648-H655
21. Alpert B., Jameson D.M., and Weber G. Photochem. Photobiol. 31 (1980) 1-4
22. In: Förster T., and Sinanoglu O. (Eds). Modern Quantum Chemistry vol. 3 (1996), Academic Press, New York 93 pp
23. Dong A.C., Huang P., and Caughey W.S. Biochemistry 29 (1990) 3303-3308
24. Snyder S.L., and Sobocinski P.Z. Anal. Biochem. 64 (1975) 284-288
25. Laemmli U.K. Nature 277 (1970) 680-685
26. Jones G., Willett P., and Glen R.C. J. Mol. Biol. 245 (1995) 43-53
27. CORINA, version 2.6, Molecular Networks GmbH, Computerchemie, Nägelsbachstraße 25, D-91052 Erlangen, Germany, 2000. Available from: .
28. Wang R., Lai L., and Wang S. J. Comput. Aided Mol. Des. 16 (2002) 11-26
29. Kuntz I.D., Blaney J.M., Oatley S.J., Langridge R., and Ferrin T.E. J. Mol. Biol. 161 (1982) 269-288
30. Chen Y.H., and Yang J.T. Biochemistry 11 (1972) 4120-4131
31. Shobini J., Mishra A.K., Sandhya K., and Chandra N. Spectrochim. Acta A 57 (2001) 1133-1147
32. Miles J.L., Morey E., Crain F., Gross S., San Julian J., and Canady W.L. J. Biol. Chem. 237 (1962) 1319-1322
33. Lakowicz J.R. Biochemistry 12 (1973) 4161-4170
34. Maurice R.E., and Camillo A.G. Anal. Biochem. 114 (1981) 199-212
35. Wang Y.Q., Zhang H.M., Zhang G.C., Liu S.X., Zhou Q.H., Fei Z.H., and Liu Z.T. Int. J. Biol. Macromol. 41 (2007) 243-250
36. Lloyd J.B.F. Nat. Phys. Sci. 231 (1971) 64-65
37. Miller J.N. Proc. Anal. Div. Chem. Soc. 16 (1979) 203-208
38. Baldwin J., and Chothia C. J. Mol. Biol. 129 (1979) 175-220
39. Haouz A., Mohsni S.E., Zentz C., Merola F., and Alpert B. Eur. J. Biochem. 264 (1999) 250-257
40. Valeur B., and Brochon J.C. New Trends in Fluorescence Spectroscopy. sixth ed. (1999), Springer Press, Berlin 25 pp
41. Thumser A.E.A., Buckland A.G., and Wilton D.C. J. Lipid. Res. 39 (1998) 1033-1038
42. Seedher N., Singh B., and Singh P. Indian J. Pharm. Sci. 61 (1999) 143-148
43. Ross P.D., and Subramanian S. Biochemistry 20 (1981) 3096-3102
44. Aki H., and Yamamoto M. J. Pharm. Pharmacol. 41 (1989) 674-679
45. He W., Li Y., Xue C., Hu Z., Chen X., and Sheng F. Bioorg. Med. Chem. 13 (2005) 1837-1845
46. Surewicz W.K., Mantsch H.H., and Chapman D. Biochemistry 32 (1993) 389-394
47. Casal H.L., Kohler U., and Mantsch H.H. Biochim. Biophys. Acta 957 (1988) 11-20
48. Purcell J.M., and Susi H. J. Biochem. Biophys. Methods 9 (1984) 193-199
49. Liu C., Bo A., Cheng G., Lin X., and Dong S. Biochim. Biophys. Acta 1385 (1998) 53-60
50. Davies K.J., and Delsignore M.E. J. Biol. Chem. 262 (1987) 9908-9913
51. Bates D.A., and Winterbourn C.C. Biochem. J. 203 (1982) 155-160
52. Davies K.J. J. Biol. Chem. 262 (1987) 9895-9901
53. Davies K.J., Delsignore M.E., and Lin S.W. J. Biol. Chem. 262 (1987) 9902-9907
54. Misiti F., Giardina B., Mordente A., and Clementi M.E. Braz. J. Med. Biol. Res. 36 (2003) 1643-1651
55. Lundgren-Eriksson L., Carlsson A., Eksborg S., Ryd W., Vesanen R., and Hultborn R. Cancer Chemother. Pharmacol. 40 (1997) 419-424