Aberrant activation of interleukin-9 receptor and downstream stat3/5 in primary T-cell lymphomas in vivo in susceptible B6 and resistant C3H mice

In Vivo

Volumn 22, Issue 6, 2008, Pages 713-720

  Shang, Yi ^a,b   Kakinuma, Shizuko ^b   Amasaki, Yoshiko ^b   Nishimura, Mayumi ^b   Kobayashi, Yoshiro ^a   Shimada, Yoshiya ^a,b  

^a TOHO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

IL 9R ; Stat; Strain difference; T cell lymphoma

Indexed keywords

CYCLIN D1; INTERLEUKIN 9; INTERLEUKIN 9 RECEPTOR; JANUS KINASE; MESSENGER RNA; STAT3 PROTEIN; STAT5 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C3H MOUSE; C57BL 6 MOUSE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENETIC SUSCEPTIBILITY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T CELL LYMPHOMA; THYMOCYTE; X IRRADIATION;

EID: 57849161034     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Benekli M, Baer MR, Baumann H and Wetzler M: Signal transducer and activator of transcription proteins in leukemias. Blood 101: 2940-2954, 2003.
2. Calo V, Migliavacca M, Bazan V, Macaluso M, Buscemi M, Gebbia N and Russo A: STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol 197: 157-168, 2003.
3. Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG and Kanakura Y: Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J 18: 1367-1377, 1999.
4. Barata JT, Keenan TD, Silva A, Nadler LM, Boussiotis VA and Cardoso AA: Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica 89: 1459-1467, 2004.
5. Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC, Shaw LM and Wasik MA: Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 93: 9148-9153, 1996.
6. Matsushita K, Arima N, Ohtsubo H, Fujiwara H, Hidaka S, Fukumori J and Tanaka H: Frequent expression of interleukin-9 mRNA and infrequent involvement of interleukin-9 in proliferation of primary adult T-cell leukemia cells and HTLV-I infected T-cell lines. Leuk Res 21: 211-216, 1997.
7. Bergsagel D: The incidence and epidemiology of plasma cell neoplasms. Stem Cells 13(Suppl 2): 1-9, 1995.
8. Rothman N, Skibola CF, Wang SS, Morgan G, Lan Q, Smith MT, Spinelli JJ, Willett E, De Sanjose S, Cocco P, Berndt SI, Brennan P, Brooks-Wilson A, Wacholder S, Becker N, Hartge P, Zheng T, Roman E, Holly EA, Boffetta P, Armstrong B, Cozen W, Linet M, Bosch FX, Ennas MG, Holford TR, Gallagher RP, Rollinson S, Bracci PM, Cerhan JR, Whitby D, Moore PS, Leaderer B, Lai A, Spink C, Davis S, Bosch R, Scarpa A, Zhang Y, Severson RK, Yeager M, Chanock S and Nieters A: Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the Inter Lymph Consortium. Lancet Oncol 7: 27-38, 2006.
9. Kamisaku H, Aizawa S, Kitagawa M, Ikarashi Y and Sado T: Limiting dilution analysis of T-cell progenitors in the bone marrow of thymic lymphoma-susceptible B10 and -resistant C3H mice after fractionated whole-body X-irradiation. Int J Radiat Biol 72: 191-199, 1997.
10. Kamisaku H, Aizawa S, Tanaka K, Watanabe K and Sado T: Different cellular basis for the resistance of C3H and STS strain mice to the development of thymic lymphomas following fractionated whole-body irradiation: analysis using radiation bone marrow chimeras. Int J Radiat Biol 76: 1105-1111, 2000.
11. Mori N, Matsumoto Y, Okumoto M, Suzuki N and Yamate J: Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene 20: 3609-3619, 2001.
12. Maruyama M, Yamamot T, Kohara Y, Katsuragi Y, Mishima Y, Aoyagi Y and Kominami R: Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after gamma-irradiation. Biochem Biophys Res Commun 354: 209-215, 2007.
13. Suzuki G, Shimada Y, Hayashi T, Akashi M, Hirama T and Kusunoki Y: An association between oxidative stress and radiation-induced lymphomagenesis. Radiat Res 161: 642-647, 2004.
14. Nishimura M, Kakinuma S, Yamamoto D, Kobayashi Y, Suzuki K, Sado T and Shimada Y: Elevated interleukin-9 receptor expression and response to interleukin-9 and -7 in thymocytes during radiation-induced T-cell lymphomagenesis in B6C3F1 mice. J Cell Physiol 198: 82-90, 2004.
15. Chang M, Engel G, Benedict C, Basu R and McNinch J: Isolation and characterization of the human interleukin-9 receptor gene. Blood 83: 3199-3205, 1994.
16. Druez C, Coulie P, Uyttenhove C and Van Snick J: Functional and biochemical characterization of mouse P40/IL-9 receptors. J Immunol 145: 2494-2499, 1990.
17. Renauld JC, Druze C, Kermouni A, Houssiau F, Uyttenhove C, Van Roost E and Van Snick J: Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc Natl Acad Sci USA 89: 5690-5694, 1992.
18. Bauer J, Liu K, You Y and Lai S: Heteromerization of the gc chain with the interleukin-9 receptor a subunit leads to STAT activation and prevention of apoptosis. J Bio Chem 273: 9255-9260, 1998.
19. Knoops L and Renauld JC: IL-9 and its receptor: From signal transduction to tumorigenesis. Growth Factors 22: 207-215, 2004.
20. Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y Matsuzawa Y, Kitamura Y and Kanakura Y: Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 92: 1736-1744, 1993.
21. Zhao YY, Takahashi M, Gu JG, Miyoshi E, Matsumoto A, Kitazume S and Taniguchi N: Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci 99: 1304-1310, 2008
22. Cyopick P, Culliton R, Brockhausen I, Sutherland DR, Mills GB and Baker M: Role of aberrant sialylation of chronic myeloid leukemia granulocytes on binding and signal transduction by chemotactic peptides and colony stimulating factors. Leuk Lymphoma 11: 79-90, 1993.
23. Kitagawa T, Tsuruhara Y, Hayashi M, Endo T and Stanbridge EJ: A tumor-associated glycosylation change in the glucose transporter GLUT1 controlled by tumor suppressor function in human cell hybrids. J Cell Sci 108: 3735-3743, 1995.
24. Houssiau FA, Renauld JC, Stevens M, Lehmann F, Lethe B, Coulie PG and Van Snick J: Human T-cell lines and clones respond to IL-9. J Immunol 150: 2634-2640, 1993.
25. Takemoto S. Mulloy JC, Cereseto A, Migone TS, Patel BK, Matsuoka M, Yamaguchi K, Takatsuki K, Kamihira S, White JD, Leonard WJ, Waldmann T and Franchini G: Proliferation of adult T-cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc Natl Acad Sci USA 94: 13897-13902, 1997.
26. Weber-Nordt RM, Mertelsmann R and Finke J: The JAK-STAT pathway: signal transduction involved in proliferation, differentiation and transformation. Leuk Lymphoma 28: 459-467, 1998.
27. Durbin JE, Hackenmiller R, Simon MC and Levy DE: Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450, 1996.
28. Demoulin JB, Van Roost E, Stevens M, Groner B and Renauld JC: Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 274: 25855-25861, 1999.
29. Johnston CJ, Piedboeuf B, Baggs R, Rubin P and Finkelstein JN: Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat Res 142: 197-203, 1995.
30. Adachi Y, Tokuda N, Sawada T and Fukumoto T: Semiquantitative detection of cytokine messages in X-irradiated and regenerating rat thymus. Radiat Res 163: 400-407, 2005.
31. Iwabuchi C, Iwabuchi K, Kobayashi S, Ogasawara K, Negishi I, Wang BY, Wambua PP, Arase H, Fukushi N, Itoh Y, Gotohda T, Good RA and Onoe K: Deficiency in early development of the thymus-dependent cells in irradiation chimeras attributable to recipient's environment. J Immunol 146: 26-34, 1991.