Inhibition of human cytomegalovirus IE gene expression by dihydro-β-agarofuran sesquiterpenes isolated from Euonymus species

In Vivo

Volumn 22, Issue 6, 2008, Pages 787-792

  Pusztai, Rozália ^a   Hohmann, Judit ^a   Rédei, Dóra ^a   Engi, Helga ^a   Molnár, Joseph ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Antitumor promotion; Cytomegalovirus; Dihydro agarofuran; Euonymus species; IE antigen expression; Sesquiterpene

Indexed keywords

1BETA,2BETA,6ALPHA,8BETA,9ALPHA,15 HEXAHYDROXYDIHYDRO BETA AGAROFURAN POLYOL; 1BETA,2BETA,6ALPHA,9ALPHA,15 PENTAHYDROXYDIHYDRO BETA AGAROFURAN ESTER DERIVATIVE; 1BETA,6ALPHA,8BETA,9ALPHA BETA,15 PENTAHYDROXYDIHYDRO BETA AGAROFURAN ESTER DERIVATIVE; 2BETA,6ALPHA,15 TRIACETOXY 1BETA BENZOYLOXY 9ALPHA NICOTINOYLOXYDIHYDRO BETA AGAROFURAN; ANTINEOPLASTIC AGENT; DIHYDRO BETA AGAROFURAN DERIVATIVE; DIHYDRO BETA AGAROFURAN SESQUITERPENE DERIVATIVE; HEPTAHYDROXYDIHYDRO BETA AGAROFURAN DERIVATIVE; HEXAHYDROXYDIHYDRO BETA AGAROFURAN; HUMAN CYTOMEGALOVIRUS VIRUS ANTIGEN; OCTAHYDROXYDIHYDRO BETA AGAROFURAN DERIVATIVE; PENTAHYDROXYDIHYDRO BETA AGAROFURAN; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANTIBODY TITER; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; EUONYMUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; STRUCTURE ACTIVITY RELATION; TUMOR PROMOTION;

EID: 57849160711     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Gao JM, Wu WJ and Zhang JW: The dihydro-β-agarofuran sesquiterpenoids. Nat Prod Rep 24: 1153-1189, 2007.
2. Takaishi Y, Ohshima S, Nakano K, Tomimatsu T, Tokuda H, Nishino H and Imashima A: Structures of sesquiterpene polyol esters from Celastrus stephanotiifolius with potential tumor-promotion inhibitor activity. J Nat Prod 56: 815-824, 1993.
3. Jiménez IA, Bazzocchi IL, Núñez MJ, Mukainaka T, Tokuda H, Nishino H, Konoshima T and Ravelo AG: Absolute configuration of sesquiterpenes from Crossopetalum tonduzii and their inhibitory effects on Epstein-Barr virus early antigen activation in Raji cells. J Nat Prod 66: 1047-1050, 2003.
4. Ujita K, Takaishi Y, Tokuda H, Nishino H, Iwashima A and Fujita T: Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor promotion. Cancer Lett 68: 129-133, 1993.
5. Duan H, Takaishi Y, Bando M, Kido M, Imakura Y and Lee KH: Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum: A new class of potent anti-HIV agents. Tetrahedron Lett 40: 2969-2972, 1999.
6. Duan H, Takaishi Y, Imakura Y, Jia Y, Duan L, Cosentino M and Lee KH: Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A new class of potent anti-HIV agents. J Nat Prod 63: 357-361, 2000.
7. Hayashi K, Hayashi T, Ujita K and Takaishi Y: Characterization of antiviral activity of a sesquiterpene, triptofordin C-2. J Antimicrob Chemother 37: 759-768, 1996.
8. Huang G, Yan Q, Wang Z, Chen X, Zhang X, Gou Y and Li JJ: Human cytomegalovirus in neoplastic cells of Epstein-Barr virus-negative Hodgkin's disease. Int J Oncol 21: 31-36, 2002.
9. Harkins L, Volk AL, Samanta M, Gillespie GY, Mikolaenko I, Britt WJ, Bland KI and Cobbs CS: Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 360: 1557-1563, 2002.
10. Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, King PH, Nabors LB, Cobbs CG and Britt WJ: Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 62: 3347-3350, 2002.
11. Samanta M, Harkins L, Klemm K, Britt WJ and Cobbs CS: High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 170: 998-1002, 2003.
12. Cinatl J Jr, Cinatl J, Vogel J-U, Rabenau H, Kornhuber B and Doerr HW: Modulatory effect of human cytomegalovirus infection on malignant properties of cancer cells. Intervirology 39: 259-269, 1996.
13. Michaelis M, Kotchetkov R, Vogel J-U, Doerr HW and Cinatl J Jr: Cytomegalovirus infection blocks apoptosis in cancer cells. Cell Mol Life Sci 61: 1307-1316, 2004.
14. Stinski MF, Malone CL, Hermiston TW and Liu B: Regulation of human cytomegalovirus transcription. In: Herpesvirus Transcription and its Control. Wagner EK (ed.). Boca Raton, CRC Press, pp. 245-260, 1991.
15. Begley MJ, Crombie L, Fleming RA, Whiting DA, Rózsa Z, Kelényi M, Hohmann J and Szendrei K: New sesquiterpene esters from Euonymus verrucosus: The 'Ever' series. X-ray molecular structure of Ever-1. J Chem Soc Perkin Trans I, pp. 535-539, 1986.
16. Rózsa Z, Perjési A, Pelczer I, Argay G and Kálmán A: New sesquiterpene esters and alkaloids from Euonymus japonicus - The Ejap series - X-ray molecular structures of Ejap-2, Ejap-3, Ejap-4, Ejap-5, Ejap-6, and Ejap-10. J Chem Soc Perkin Trans I pp. 1079-1087, 1989.
17. Hohmann J, Nagy G, Dini Z, Günther G, Pelczer I, Jerkovich G and Varjas L: New sesquiterpene polyesters from Euonymus species. J Nat Prod 58: 1192-1199, 1995.
18. Hohmann J, Nagy G, Günther G, Argay G, Kálmán A and Czira G: Isolation and structure elucidation of four new dihydroagarofuran polyesters from Euonymus sachalinensis. J Chem Soc Perkin Trans I pp. 3281-3285, 1994.
19. Hohmann J and Günther G: Kiautschovin, a novel sesquiterpenoid from Euonymus kiautschovicus. J Nat Prod 57: 320-323, 1994.
20. Hohmann J, Dini Z, Pelczer I and Jerkovich G: Sesquiterpene esters from Euonymus nanus. Phytochemistry 35: 1267-1270, 1994.
21. Pusztai R, Ferreira MJU, Duarte N, Engi H and Molnár J: Macrocyclic lathyrane diterpenes as antitumor promoters. Anticancer Res 27: 201-206, 2007.
22. Alberts AS, Colvin OM, Conney AH, Emster VL, Garber JE and Greenwald P: Prevention of cancer in the next millenium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res 59: 4743-4758, 1999.
23. Morse MA and Storner GD: Cancer chemoprevention: principles and prospects. Carcinogenesis 14: 1737-1746, 1993.
24. Watteberg LW: Chemoprevention of cancer. Cancer Res 45: 1-8, 1985.
25. Cinatl J Jr, Vogel JU, Kotchetkov R and Doerr HW: Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: novel role for viral infection in tumor progression. FEMS Microbiol Rev 28: 59-77, 2004.