Use of palliative sedation for intractable symptoms in the palliative care unit of a comprehensive cancer center

Supportive Care in Cancer

Volumn 17, Issue 1, 2009, Pages 53-59

  Elsayem, Ahmed ^a   Curry III, Eardie ^a   Boohene, Jeanette ^a   Munsell, Mark F ^a   Calderon, Bianca ^a   Hung, Frank ^a   Bruera, Eduardo ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Midazolam; Palliative care unit; Palliative sedation

Indexed keywords

CHLORPROMAZINE; HALOPERIDOL; LORAZEPAM; MIDAZOLAM; OLANZAPINE; OPIATE; PROPOFOL; QUETIAPINE; STEROID;

ADULT; AGED; ARTICLE; BEHAVIOR THERAPY; CANCER CENTER; CANCER PAIN; CANCER PALLIATIVE THERAPY; CLINICAL PRACTICE; CONTINUOUS INFUSION; DELIRIUM; DOSAGE SCHEDULE COMPARISON; DRUG DOSE TITRATION; DRUG MEGADOSE; DYSPNEA; FEMALE; HEALTH CARE POLICY; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PATIENT IDENTIFICATION; PRIORITY JOURNAL; PSYCHOTHERAPY; RETROSPECTIVE STUDY; SEDATION; SEIZURE; SYMPTOM; TREATMENT INDICATION; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; CANCER CARE FACILITIES; CHLORPROMAZINE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; LORAZEPAM; MALE; MIDAZOLAM; MIDDLE AGED; NEOPLASMS; PALLIATIVE CARE; PHYSICIAN'S PRACTICE PATTERNS; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 57849136054     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-008-0459-4     Document Type: Article

References (37)

1. American Academy of Hospice and Palliative Medicine. Statement on Palliative Sedation, Sept. 2006. www.aahpm.org/position
2. W Breitbart C Gibson A Tremblay 2002 The delirium experience: delirium recall and delirium-related distress in hospitalized patients with cancer, their spouses/caregivers, and their nurses Psychosomatics 43 183 194
3. W Breitbart R Marotta MM Platt 1996 Double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients Am J Psychiatry 153 231 237
4. E Bruera N Kuehn MJ Miller 1991 The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients J Palliat Care 7 6 9
5. E Bruera CM Neumann 1998 The uses of psychotropics in symptom management in advanced cancer Psychooncology 7 346 358
6. D Cameron D Bridge J Blitz-Lindeque E Bruera 2004 Use of sedation to relieve refractory symptoms in dying patients S Afr Med J 94 445 449
7. S Chater R Viola J Paterson V Jarvis 1998 Sedation for intractable distress in the dying-a survey of experts Palliat Med 12 255 269
8. C Cheng C Roemer-Becuwe J Pereira 2002 When midazolam fails J Pain Symptom Manage 23 256 265
9. NI Cherny RK Portenoy 1994 Sedation in the management of refractory symptoms: guidelines for evaluation and treatment J Palliat Care 1010 31 38
10. J Cowan D Walsh 2001 Terminal sedation in palliative medicine: definition and review of the literature Support Care Cancer 9 403 407
11. de Graeff A, Strasser F. Indications and conditions for palliative sedation. EAPC Forum from the 9th Congress of EAPC, April 2005. www.eapcnet.org/forum
12. E Del Fabbro S Dalal E Bruera 2006 Symptom control in palliative care-Part III: dyspnea and delirium J Palliat Med 9 422 436
13. E Del Fabbro SG Reddy P Walker E Bruera 2007 Palliative sedation: when the family and consulting service see no alternative J Palliat Med 10 2 488 492
14. SH Drummond GM Peterson JG Galloway PA Keefe 1996 National survey of drug use in palliative care Palliat Med 10 119 124
15. A Elsayem K Swint MJ Fisch 2004 Palliative care inpatient service in a comprehensive cancer center: clinical and financial outcomes J Clin Oncol 22 2008 2014
16. J Engstrom E Bruno B Holm O Hellzen 2006 Palliative sedation at end of life-a systematic literature review Eur J Oncol Nurs 11 1 26 35
17. RL Fainsinger A Waller M Bercovici 2000 A multi-center international study of sedation for uncontrolled symptoms in terminally ill patients Palliat Med 14 257 265
18. A Foy D O'Connell D Henry J Kelly S Cocking J Halliday 1995 Benzodiazepine use as a cause of cognitive impairment in elderly hospital inpatients J Gerontol A Biol Sci Med Sci 50 2 99 106
19. JD Gaudreau P Gagnon F Harel MA Roy A Tremblay 2005 Psychoactive medications and risk of delirium in hospitalized cancer patients J Clin Oncol 23 27 6712 6718
20. JD Gaudreau P Gagnon MA Roy F Harel A Tremblay 2007 Opioid medications and longitudinal risk of delirium in hospitalized cancer patients Cancer 109 11 2365 2373
21. AD Graeff M Dean 2007 Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards Palliat Med 10 67 85
22. PG Lawlor ED Bruera 2002 Delirium in patients with advanced cancer Hematol Oncol Clin North Am 16 701 714
23. PG Lawlor B Gagnon IL Mancini 2000 Occurrence, causes, and outcome of delirium in patients with advanced cancer: a prospective study Arch Intern Med 160 6 786 794
24. MH Levy SD Cohen 2005 Sedation for the relief of refractory symptoms in the imminently dying: a fine intentional line Semin Oncol 32 2 237 246
25. B Lo G Rubenfeld 2005 Palliative sedation in dying patients: "we turn to it when everything else hasn't worked" JAMA 294 1810 1816
26. S Lundstrom U Zachrisson CJ Furst 2005 When nothing helps: propofol as sedative and antiemetic in palliative cancer care J Pain Symptom Manage 30 570 577
27. B Mclver D Walsh K Nelson 1994 The use of chlorpromazine for symptom control in dying cancer patients J Pain Symptom Manage 9 341 345
28. T Morita S Bito Y Kurihara Y Uchitomi 2005 Development of clinical guideline for palliative sedation therapy using the Delphi method J Palliat Med 8 716 729
29. M Pecking F Montestruc P Marquet E Wodey M Homery P Dostert 2002 Absolute bioavailability of midazolam after subcutaneous administration to healthy volunteers Br J Clin Pharmacol 54 357 362
30. J Pereira J Hanson E Bruera 1997 The frequency and clinical course of cognitive impairment in patients with terminal cancer Cancer 79 835 842
31. JG Reves J Fragen H Vinik J Greenblatt 1985 Midazolam: pharmacology and uses Anesthesiology 62 310 324
32. PC Rousseau 2006 Palliative sedation and the fear of legal ramifications J Palliat Med 9 246 247
33. J Sales 2001 Sedation and terminal care Eur J Palliat Care 8 97 100
34. P Stevanovic 2006 Midazolam (dormicump)-clinical practice guidelines Med Pregl 59 89 94
35. P Stone C Phillips O Spruyt C Waight 1997 A comparison of the use of sedatives in a hospital support team and in a hospice Palliat Med 11 140 144
36. N Sykes A Thorns 2003 Sedative use in the last week of life and the implications for end-of-life decision-making Arch Intern Med 163 341 344
37. JR Thomas CF von Gunten 2003 Management of dyspnea J Support Oncol 1 23 32