Preparative isolation of closely-related xanthones from gentianella amarella ssp. acuta by high-speed countercurrent chromatography

Phytochemical Analysis

Volumn 19, Issue 6, 2008, Pages 514-519

  Urbain, Aurélie ^a   Marston, Andrew ^a   Batsuren, Dulamjav ^b   Purev, Ondognii ^b   Hostettmann, Kurt ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Laboratory of Natural Substance Chemistry   (Mongolia)

Author keywords

Gentianaceae; Gentianella amarella ssp. acuta; High speed countercurrent chromatography; Xanthone aglycones; Xanthone glycosides

Indexed keywords

LIQUID CHROMATOGRAPHY; SUGARS;

ACETYLCHOLINESTERASE; ACUTA; AGLYCONES; GENTIANACEA; GENTIANELLUM AMARELLUM SSP.; HIGHSPEED COUNTERCURRENT CHROMATOGRAPHIES (HSCCC); METHANOLIC EXTRACTS; PREPARATIVE ISOLATION; XANTHONE AGLYCONE; XANTHONE GLYCOSIDE;

FRACTIONATION;

AGLYCONE; GLYCOSIDE; METHANOL; XANTHONE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; BIOASSAY; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; GENTIANELLA; GENTIANELLA AMARELLA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; ISOMERISM; NONHUMAN; PHYTOCHEMISTRY; PROCESS OPTIMIZATION; SEPARATION TECHNIQUE; SOLVENT EXTRACTION;

GENTIANACEAE; GENTIANELLA AMARELLA;

EID: 57849125559     PISSN: 09580344     EISSN: 10991565     Source Type: Journal    
DOI: 10.1002/pca.1077     Document Type: Article

References (24)

1. Afzal M, Al-Hassan JM, Al-Masad FN. 1979. Absorption spectra of phytoxanthones. Heterocycles 12: 269-299.
2. Brühlmann C, Marston A, Hostettmann K, Carrupt P-A, Testa B. 2004. Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors. Chem Biodiversity 1: 819-829.
3. Dua VK, Ojha VP, Roy R, Joshi BC, Valecha N, Devi CU, Bhatnagar MC, Sharma VP, Subbarao SK. 2004. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J Ethnopharmacol 95: 247-251.
4. Fotie J, Bohle DS. 2006. Pharmacological and biological activities of xanthones. Anti-Infect Agents Med Chem 5: 15-31.
5. Hostettmann K, Hostettmann M. 1989. Xanthones. In Methods in Plant Biochemistry - Volume I. Plant Phenolics, Dey PM, Harborne JB (ed.). Academic Press: London; 493-508.
6. Hostettmann K, Marston A, Hostettmann M. 1998. Preparative Chromatography Techniques: Applications in Natural Product Isolation, 2nd edn. Springer: Berlin.
7. Isaka M, Palasarn S, Kocharin K, Saenboonrueng J. 2005. A cytotoxic xanthone dimer from the entomopathogenic fungus Aschersonia sp. BCC 8401. J Nat Prod 68: 945-946.
8. Kaldas M, Hostettmann K, Jacot-Guillarmod A. 1974. Contribution à la phytochimie du genre Gentiana IX. Etude de composés flavoniques et xanthoniques dans les feuilles de Gentiana campestris L. Helv Chim Acta 57: 2557-2561.
9. Kaldas M, Hostettmann K, Jacot-Guillarmod A. 1975. Contribution à la phytochimie du genre Gentiana XIII. Etude de composés flavoniques et xanthoniques dans les feuilles de Gentiana campestris L. Helv Chim Acta 58: 2188-2192.
10. Kojima K, Ondognij P, Davgiin K, Ogihara Y. 1998. Xanthones from Gentiana acuta. Nat Med 52: 87-89.
11. Lee BW, Lee JH, Lee S-T, Lee HS, Lee WS, Jeong T-S, Park KH. 2005. Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata. Bioorg Med Chem Lett 15: 5548-5552.
12. Lin C-N, Liou S-J, Lee T-H, Chuang Y-C, Won S-J. 1996. Xanthone derivatives as potential anti-cancer drugs. J Pharm Pharmac 48: 539-544.
13. Markham KR. 1964. Gentian pigments I. Xanthones from Gentiana bellidifolia. Tetrahedron 20: 991-997.
14. Marston A, Hostettmann K. 2006. Developments in the application of counter-current chromatography to plant analysis. J Chromatogr A 1112: 181-194.
15. Marston A, Kissling J, Hostettmann K. 2002. A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants. Phytochem Anal 13: 51-54.
16. Otsuka H. 1999. Triptexanthosides A-E: xanthone glycosides from aerial parts of Tripterospermum japonicum. Chem Pharm Bull 47: 962-965.
17. Rath G, Potterat O, Mavi S, Hostettmann K. 1996. Xanthones from Hypericum roeperanum. Phytochemistry 43: 513-520.
18. Rezanka T, Jachymova J, Dembitsky VM. 2003. Prenylated xanthone glucosides from Ural's lichen Umbilicaria proboscidea. Phytochemistry 62: 607-612.
19. Suzuki O, Katsumata Y, Oya M, Chari VM, Vermes B, Wagner H, Hostettmann K. 1981. Inhibition of type A and type B monoamine oxidases by naturally occurring xanthones. Planta Med 42: 17-21.
20. Terreaux C, Maillard M, Gupta MP, Hostettmann K. 1995. Xanthones from Schultesia lisianthoides. Phytochemistry 40: 1791-1795.
21. Urbain A, Marston A, Queiroz EF, Ndjoko K, Hostettmann K. 2004. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med 70: 1011-1014.
22. Urbain A, Marston A, Sintra Grilo L, Bravo J, Purev O, Purevsuren B, Batsuren D, Reist M, Carrupt P-A, Hostettmann K. 2008. Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. J Nat Prod (DOI: 10.1021/ np0706901).
23. Yang YB, Zhou J. 1980. Studies on the xanthones of Veratrilla baillonii Franch. I. Structures of veratriloside and veratrilogenin. Yaoxue Xuebao 15: 625-629.
24. Zhou H, Liu Y, Blasko G, Cordell GA. 1989. Swertiabisxanthone-I from Swertia macrosperma. Phytochemistry 28: 3569-3571.