Effective methylphenidate treatment of an adult aspergers syndrome and a comorbid ADHD: A clinical investigation with fMRI

Journal of Attention Disorders

Volumn 12, Issue 4, 2009, Pages 381-385

  Roy, Mandy ^a   Dillo, Wolfgang ^a   Bessling, Svenja ^a   Emrich, Hinderk M ^a   Ohlmeier, Martin D ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

AD HD; ADHD; Aspergers Syndrome; FMRI; Methylphenidate

Indexed keywords

CENTRAL STIMULANT AGENT; METHYLPHENIDATE;

ADULT; ARTICLE; ASPERGER SYNDROME; ATTENTION DEFICIT DISORDER; BRAIN; CASE REPORT; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY;

ADULT; ASPERGER SYNDROME; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METHYLPHENIDATE;

EID: 57849122985     PISSN: 10870547     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087054708320436     Document Type: Article

References (15)

1. Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient (EQ): An investigation of adults with Asperger Syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34, 163-175.
2. Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism spectrum quotient (AQ): Evidence from Asperger syndrome/high functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5-17.
3. Krause, J., & Krause, K.H. (2005). ADHS im Erwachsenenalter. Stuttgart, Germany and New York: Schattauer.
4. Lee, D.O., & Ousley, O.Y. (2006). Attention-deficit/hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 16, 737-746.
5. Remschmidt, H., & Kamp-Becker, I. (2006). Asperger-syndrome. Berlin, Germany: Springer.
6. Sandler, A.D., Hooper, S.R., Watson, T.E., Coleman, W.L., Footo, M., & Levine, M.D. (1993). Talkative children: Verbal fluency as a marker for problematic peer relationships in clinic-referred children with attention deficits. Perceptual and Motor Skills, 76 (3 Pt. 1). 943-951.
7. Santosh, P.J., & Mijovic, A. (2004). Social impairment in hyperkinetic disorder-Relationship to psychopathology and environmental stressors. European Child & Adolescent Psychiatry, 13 (3). 141-150.
8. Schultz, R.T., Gauthier, I., Klin, A., Fulbright, R.K., Anderson, A.W., Volkmar, F., et al. (2000). Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Archives of General Psychiatry, 57, 331-340.
9. Shamay-Tsoory, S.G., Tomer, R., Yaniv, S., & Aharon-Peretz, J. (2002). Empathy deficits in Asperger syndrome: A cognitive profile. Neurocase, 8, 245-252.
10. Silk, T., Vance, A., Rinehart, N., Egan, G., O'Boyle, M., Bradshaw, J.L., et al. (2005). Fronto-parietal activation in attention-deficit/hyperactivity disorder, combined type: Functional magnetic resonance imaging study. British Journal of Psychiatry, 187, 282-283.
11. Smith, A.B., Taylor, E., Brammer, M., Toone, B., & Rubia, K. (2006). Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-Naive children and adolescents with attention deficit/hyperactivity disorder. American Journal of Psychiatry, 163, 1044-1051.
12. Stroes, A., Alberts, E., & Van Der Meere, J.J. (2003). Boys with ADHD in social interaction with a nonfamiliar adult: An observational study. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 295-302.
13. Sturm, H., Fernell, E., & Gillberg, C. (2004). Autism spectrum disorders in children with normal intellectual levels: Associated impairments and subgroups. Developmental Medicine & Child Neurology, 46, 444-447.
14. Szobot, C.M., Ketzer, C., Cunha, R.D., Parente, M.A., Langleben, D.D., Acton, P.D., et al. (2003). The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder. European Journal of Nuclear Medicine and Molecular Imaging, 30, 423-426.
15. Tamm, L., Menon, V., & Reiss, A.L. (2006). Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: Event-related fMRI evidence. American Journal of Psychiatry, 163, 1033-1043.