Early modification of c-myc, Ha-ras and p53 expressions by N-methyl-N-nitrosourea

In Vivo

Volumn 22, Issue 6, 2008, Pages 793-798

  Budán, Ferenc ^a   Varjas, Tímea ^a   Nowrasteh, Ghodratollah ^a   Varga, Zsuzsa ^b   Boncz, Imre ^a   Cseh, József ^c   Prantner, Ida ^a   Antal, Tibold ^a   Pázsit, Emese ^d   Góbel, Gyula ^a   Bauer, Miklós ^a   Gracza, Tünde ^a   Perjési, Pál ^e   Ember, István ^a   Gyóngyi, Zoltán ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Baranya County Hospital   (Hungary)

^c Department of Oncology   (Hungary)

^d Hospital and Clinic of Diósgyor   (Hungary)

^e UNIVERSITY OF PÉCS   (Hungary)

Author keywords

c myc; Carcinogenesis; DMBA; Gene expression; Ha ras; Mice; MNU; p53; ras

Indexed keywords

CARCINOGEN; HA RAS PROTEIN; MESSENGER RNA; METHYLNITROSOUREA; MYC PROTEIN; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CARCINOGENIC ACTIVITY; CBA MOUSE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; GENE OVEREXPRESSION; MALE; MOUSE; NONHUMAN; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION;

EID: 57849114405     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Sen NP, Seaman SW, Burgess C, Baddoo PA and Weber D: Investigation on the possible formation of N-nitroso-N-methylurea by nitrosation of creatinine in model systems and in cured meats at gastric pH. J Agric Food Chem 48: 5088-5096, 2000.
2. McCaffrey J and Hamilton JW: Comparison of effects of direct-acting DNA methylating and ethylating agents on inducible gene expression in vivo. Environ Mol Mutagen 23: 164-170, 2006.
3. Lee JS, Park EH, Choe J and Chipman JK: N-methyl-N-nitrosourea (MNU) induces papillary thyroid tumours which lack ras gene mutations in the hermaphroditic fish Rivulus marmoratus. Terat Carc Mutagen 20: 1-9, 1999.
4. Tudek B, Bird RP and Bruce WR: Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods. Cancer Res 49: 1236-1240, 1989.
5. Benavides F, Gomez G, Venables-Griffith A, Lambertz I, Flores M, Angel JM, Fuchs-Young R, Richie ER and Conti CJ: Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice. Mol Carcinog 45: 543-548, 2006.
6. Quintanilla M, Brown K, Ramsden M and Balmain A: Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322: 78-80, 1986.
7. Gyöngyi Z, Ember I, Kiss I and Varga C: Changes in expression of onco- and suppressor genes in peripheral leukocytes as potential biomarkers of chemical carcinogenesis. Anticancer Res 21: 3377-3380, 2001.
8. Gyöngyi Z, Grama L, Nádasi E, Sándor J, Németh A, Varga C, Kiss I and Ember I: Flow cytometric analysis of DMBA-induced early in vivo ras expression. In Vivo 16: 323-326, 2002.
9. Ember I, Kiss I, Gombköto G, Müller E and Szeremi M: Oncogene and supressor gene expression as a biomarker for ethylene oxide exposure. Cancer Detect Prev 22: 241-245, 1998.
10. Kozma L, Kiss I, Nagy A, Szakall S and Ember I: Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma. Cancer Lett 111: 127-131, 1997.
11. Pelling JC, Ernst SM, Strawhecker JM, Johnson JA, Nairn RS and Slaga TJ: Elevated expression of Ha-ras is an early event in two-stage carcinogenesis in SENCAR mice. Carcinogenesis 9: 1599-1602, 1986.
12. Pelling JC, Fisher SM, Neades R, Strawecker J and Schweicker L: Elevated expression and point mutation of the Ha-ras protooncogene in mouse skin tumors promoted by benzyl peroxide and other promoting agents. Carcinogenesis 8: 1481-1484, 1987.
13. Walker DR, Bond JP, Tarone RE, Harris CC, Makalowski W, Boguski MS and Greenblatt MS: Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features. Oncogene 18: 211-218, 1999.
14. Ember I, Kiss I and Pusztai Z: Effect of 7,12-dimethylbenz(a)anthracene on onco/suppressor gene action in vivo: a short-term experiment. Anticancer Res 18: 445-447, 1998.
15. Szanyi I, Lujber L, Gerlinger I, Pytel J, Bauer M, Csejtey A, Szele E, Gombos K, Kiss I, Seredenin S, Yarkova M and Ember I: In vivo effects of afobazole (2-mercaptobenzimidazole derivative) on the 7,12-dimethylbenz[alpha]anthracene-induced oncogene and suppressor gene expression. In Vivo 21: 1059-1063, 2007.
16. Perjési P, Bayer Z and Ember I: Effect of E-2-(4′-methoxybenzylidene)-1-benzosuberone on the 7,12-dimethyl-benz[a]anthracene-induced onco/suppressor gene action in vivo I: A 48-hour experiment. Anticancer Res 20: 475-482, 2000.
17. Hoivik DJ, Allen JS, Wall HG, Nold JB, Miller RT and Santostefano MJ: Studies evaluating the utility of N-methyl-N-nitrosourea as a positive control in carcinogenicity studies in the p53 +/- mouse. Int J Toxicol 24: 349-356, 2005.
18. 6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53-deficient mice. Oncogene 20: 5258-5263, 2001.
19. Weinkam RJ and Dolan ME: Intracellular activation of cytotoxic agents: kinetic models for methylnitrosoureas and N-methyl-N′,-nitro-N-nitrosoguanidine in cell culture. Chem Res Toxicol 2: 157-161, 1989.
20. Kang HM, Jang JJ, Langford C, Shin SH, Park SY and Chung YJ: DNA copy number alterations and expression of relevant genes in mouse thymic lymphomas induced by gamma-irradiation and N-methyl-N-nitrosourea. Cancer Genet Cytogenet 166: 27-35, 2006.
21. Becci PJ, Thompson HJ, Grubbs CJ and Moon RC: Histogenesis and dose dependence of N-methyl-N-nitrosourea-induced carcinoma in a localized area of the hamster trachea. J Natl Cancer Inst 64: 1135-1140, 1980.
22. Seidel HJ and Kreja L: Leukemia induction by methylnitrosourea (MNU) in selected mouse strains. Effects of MNU on hemopoietic stem cells, the immune system and natural killer cells. J Cancer Res Clin Oncol 108: 214-220, 1984.
23. Seidel HJ and Kreja L: T-cell subsets in the murine thymus during chemically induced leukemogenesis. Folia Histochem Cytobiol 24: 27-31, 1986.
24. Talcott PA, Exon JH and Koller LD: The effects of methylnitrosourea (MNU) on natural killer (NK) cell cytotoxicity and cytokine production in rats. Carcinogenesis 5: 829-34, 1990.
25. Weinkam RJ and Keenan TH: A method for measuring the lifetime of chemically and metabolically generated electrophilic species. Chem Biol Interact 46: 255-264, 1983.
26. Ember I, Gyöngyi Z, Kiss I, Ghodratollah N and Arany I: The possible relationship between onco/suppressor gene expression and carcinogen exposure in vivo: evaluation of a potential biomarker in preventive and predictive medicine. Anticancer Res 22: 2109-2116, 2002.
27. Flesher JW, Horn J and Lehner AF: 7-Sulfooxymethyl-12-methylbenz[a]anthracene is an exceptionally reactive electrophilic mutagen and ultimate carcinogen. Biochem Biophys Res Commun 231: 144-148, 1997.