Extended hepatectomy with segments I and VII as resection remnant: A simple model for small-for-size injuries in pigs

Hepatobiliary and Pancreatic Diseases International

Volumn 7, Issue 6, 2008, Pages 601-607

  Xia, Qiang ^a   Lu, Tian Fei ^a   Zhou, Zhi Hua ^a   Hu, Ling Xiang ^a   Ying, Jun ^a   Ding, De Zhong ^b   Chen, Xiao Song ^a   Zhang, Jian Jun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Tyco Clinical Institute   (China)

Author keywords

Hepatectomy; Small for size syndrome

Indexed keywords

ALANINE AMINOTRANSFERASE; BILIRUBIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DISEASE MODEL; FEMALE; INTERNATIONAL NORMALIZED RATIO; LIVER FUNCTION TEST; LIVER INJURY; LIVER RESECTION; LIVER STRUCTURE; LIVER WEIGHT; NONHUMAN; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRESSURE GRADIENT; REPRODUCIBILITY; SIMULATION; SMALL FOR SIZE SYNDROME; SURGICAL APPROACH; SURGICAL TECHNIQUE; SURVIVAL RATE; SWINE;

ANIMALS; DELAYED GRAFT FUNCTION; DISEASE MODELS, ANIMAL; FEMALE; HEPATECTOMY; HYPERTENSION, PORTAL; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; ORGAN SIZE; PORTAL PRESSURE; SURVIVAL RATE; SUS SCROFA;

EID: 57849113484     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kiuchi T, Kasahara M, Uryuhara K, Inomata Y, Uemoto S, Asonuma K, et al. Impact of graft size mismatching on graft prognosis in liver transplantation from living donors. Transplantation 1999;67:321-327.
2. Dahm F, Georgiev P, Clavien PA. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant 2005; 5:2605-2610.
3. Man K, Fan ST, Lo CM, Liu CL, Fung PC, Liang TB, et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003;237:256-264.
4. Troisi R, de Hemptinne B. Clinical relevance of adapting portal vein flow in living donor liver transplantation in adult patients. Liver Transpl 2003;9:S36-41.
5. Court FG, Wemyss-Holden SA, Morrison CP, Teague BD, Laws PE, Kew J, et al. Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy. Br J Surg 2003;90:440-444.
6. Court FG, Laws PE, Morrison CP, Teague BD, Metcalfe MS, Wemyss-Holden SA, et al. Subtotal hepatectomy: a porcine model for the study of liver regeneration. J Surg Res 2004;116:181-186.
7. Biecker E, Roth F, Heller J, Schild HH, Sauerbruch T, Schepke M. Prognostic role of the initial portal pressure gradient reduction after TIPS in patients with cirrhosis. Eur J Gastroenterol Hepatol 2007;19:846-852.
8. Samonakis DN, Cholongitas E, Thalheimer U, Kalambokis G, Quaglia A, Triantos CK, et al. Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosis. Liver Transpl 2007;13: 1305-1311.
9. Nagino M, Ando M, Kamiya J, Uesaka K, Sano T, Nimura Y. Liver regeneration after major hepatectomy for biliary cancer. Br J Surg 2001;88:1084-1091.
10. Ito T, Kiuchi T, Yamamoto H, Oike F, Ogura Y, Fujimoto Y, et al. Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications. Transplantation 2003;75:1313-1317.
11. Kelly DM, Demetris AJ, Fung JJ, Marcos A, Zhu Y, Subbotin V, et al. Porcine partial liver transplantation: a novel model of the "small-for-size" liver graft. Liver Transpl 2004;10:253-263.
12. Yoshizumi T, Taketomi A, Soejima Y, Ikegami T, Uchiyama H, Kayashima H, et al. The beneficial role of simultaneous splenectomy in living donor liver transplantation in patients with small-for-size graft. Transpl Int 2008;21:833-842.
13. Kokai H, Sato Y, Yamamoto S, Oya H, Nakatsuka H, Watanabe T, et al. Successful super-small-for-size graft liver transplantation by decompression of portal hypertension via splenectomy and construction of a mesocaval shunt: a case report. Transplant Proc 2008;40: 2825-2827.
14. Asakura T, Ohkohchi N, Orii T, Koyamada N, Tsukamoto S, Sato M, et al. Effect of reduction of portal vein pressure on the outcome of extreme small size liver transplants. Transplant Proc 2002;34:2782-2783.
15. Yamada T, Tanaka K, Uryuhara K, Ito K, Takada Y, Uemoto S. Selective hemi-portocaval shunt based on portal vein pressure for small-for-size graft in adult living donor liver transplantation. Am J Transplant 2008;8:847-853.
16. Takahashi T. Experimental study on orthotopic liver transplantation using veno-venous bypass in the pig - the evaluation of hemodynamic alterations and the estimation of appropriate bypass flow during the period of the ahepatic state. Hokkaido Igaku Zasshi 1987;62:616-628.
17. Eason J, Tan K, Howard E, Bras P, Pastellopoulos A, Patrapinyokul S, et al. Comparative hemodynamics of venovenous and venoarterial bypass during liver transplantation in the pig. Transplant Proc 1989;21:3525.
18. Ladurner R, Hochleitner B, Schneeberger S, Barnas U, Krismer A, Kleinsasser A, et al. Extended liver resection and hepatic ischemia in pigs: a new, potentially reversible model to induce acute liver failure and study artificial liver support systems. Eur Surg Res 2005;37:365-369.
19. Kahn D, van Hoorn-Hickman R, Terblanche J. Liver blood flow after partial hepatectomy in the pig. J Surg Res 1984; 37:290-294.
20. Kukita K, Katsuramaki T, Kikuchi H, Meguro M, Nagayama M, Kimura H, et al. Remnant liver injury after hepatectomy with the pringle maneuver and its inhibition by an iNOS inhibitor (ONO-1714) in a pig model. J Surg Res 2005;125:78-87.
21. Tonnesen K. Experimental liver failure. A comparison between hepatectomy and hepatic devascularization in the pig. Acta Chir Scand 1977;143:271-277.
22. Kamimura R, Ishizaki N, Suzuki S, Tanaka K, Taira A. Division of donor liver for successful split-liver transplantation in pigs. Exp Anim 1997;46:315-317.