Gelatin microspheres of rifampicin cross-linked with sucrose using thermal gelation method for the treatment of tuberculosis

Journal of Microencapsulation

Volumn 26, Issue 1, 2009, Pages 83-89

  Samad, Abdus ^a   Sultana, Yasmin ^a   Khar, Roop K ^a   Chuttani, K ^b   Mishra, A K ^b  

^a HAMDARD UNIVERSITY   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Cross linked; DSC; FT IR; Rifampicin; Sugar; Thermal gelation method

Indexed keywords

GELATIN; MICROSPHERE; PERTECHNETIC ACID TC 99M; PLACEBO; RIFAMPICIN; SUCROSE; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; ENCAPSULATION; GAMMA SCINTIGRAPHY; GELATION; INFRARED SPECTROSCOPY; ISOTOPE LABELING; MICROSCOPY; NONHUMAN; PARTICLE SIZE; RADIOACTIVITY; SCANNING ELECTRON MICROSCOPY; THERMOREGULATION; TUBERCULOSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTIBIOTICS, ANTITUBERCULAR; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; GASTROINTESTINAL TRACT; GELATIN; GELS; HOT TEMPERATURE; MICROSPHERES; RIFAMPIN; SUCROSE; TECHNETIUM; TUBERCULOSIS;

EID: 57849099652     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040802172638     Document Type: Article

References (15)

1. Arshady, R. (1990) Albumin microspheres and microcapsules: Methodology of manufacturing techniques. J Control Rel, 14, pp. 111-131.
2. Chiao, CSL and Price, JC (1989) Modification of gelatin beadlets for zero order sustained release. Pharm Res, 6, pp. 517-520.
3. Digenis, GA, Thomas, BG and Shah, VP (1994) Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance. J Pharm Sci, 83, pp. 915-921.
4. Esposito, E., Cortesi, R. and Nastruzzi, C. (1996) Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties. Biomaterials, 17, pp. 2009-2020.
5. Hakata, T., Sato, H., Watanable, Y. and Matsymoto, M. (1994) Effect of formaldehyde on the physiochemical properties of soft gekatin capsule shells. Chem Pharm Bull, 42, pp. 1138-1142.
6. Hodge, JE (1955) The amadori rearrangement. Adv Carbohydrate Chem, 10, pp. 169-205.
7. Kamath, KR and Park, K. (1993) Biodegradable hydrogels in drug delivery. Adv Drug Del Rev, 11, pp. 59-84.
8. Lee, KC, Lee, YJ, Kim, WB and Cha, CY (1990) Monoclonal antibody-based targeting of methotrexate-loaded microspheres. Int J Pharm, 59, pp. 27-33.
9. Majors, KR and Friedman, MB (1991) Animal testing of polymer based system. Polymers for controlled drug delivery, pp. 231-239. CRC Press Inc., Boca Raton, FL
10. Nahahoka, R., Tabata, Y. and Ikada, Y. (1994) Potentially of gelatin microspheres as immunological adjuvant. Vaccine, 13, pp. 653-661.
11. Nastruzzi, C., Esposito, E., Cotesi, R., Gambari, R. and Menegatti, E. (1994) Kinetics of bromocriptine release from microspheres: Comparative analysis between different in vitro models. J Microencapsulation, 11, pp. 565-574.
12. Nastruzzi, C., Pasteseni, C., Cortesi, R., Esposito, E., Gambari, R. and Menegatti, E. (1994) Production and in vitro evaluation of gelatin microspheres containing an antitumor tetra-amide. J Microencapsulation, 11, pp. 249-260.
13. Pecosky, DA and Robinsonn, JR (1991) Bioadhesive polymers and drug delivery. Polymers for controlled drug delivery, pp. 99-125. CRC Press, Boca Raton, FL
14. Ruys, L., Vermeesh, J., Schacht, E. and Goethals, E. (1983) Polymer drug combinations. VII. Polymethacrylates and modified polysaccharides with potential antiarrhythmic activity. Acta Pharm Technol, 29, pp. 105-112.
15. 99mTc HAS. J Nucl Med, 19, pp. 796-803.