Development and validation of a multi-dose neutropenic rat thigh infection model using real-time monitoring of Staphylococcus aureus growth in vivo

In Vivo

Volumn 22, Issue 6, 2008, Pages 667-672

  Zhang, Hong ^a   Kalkeri, Gururaj ^a   Mani, Nagraj ^a   Grossman, Trudy H ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Bioluminescence; Rat thigh infection; Staphylococcus aureus

Indexed keywords

VANCOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BIOLUMINESCENCE; COLONY FORMING UNIT GM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; IN VIVO STUDY; INTERMETHOD COMPARISON; NEUTROPENIA; NONHUMAN; RAT; REAL TIME BIOLUMINESCENT INFECTION MONITORING; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; THIGH; VALIDITY;

EID: 57849097602     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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