TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance

Annals of the New York Academy of Sciences

Volumn 1150, Issue , 2008, Pages 149-151

  Miller, David M ^a   Thornley, Thomas ^a   Pearson, Todd ^a   Yamazaki, Masahiro ^a   Brehm, Michael A ^a   Rossini, Aldo A ^a   Greiner, Dale L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Co stimulation blockade; Hematopoietic chimerism; Tolerance; Toll like receptors

Indexed keywords

CD4 ANTIBODY; INTERFERON; OKT 8; TOLL LIKE RECEPTOR AGONIST;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHIMERA; CONFERENCE PAPER; COSTIMULATION BLOCKADE; GRAFT SURVIVAL; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; RECEPTOR UPREGULATION; SKIN ALLOGRAFT; TRANSPLANTATION TOLERANCE;

MUS;

EID: 57749200465     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1447.034     Document Type: Conference Paper

References (4)

1. Seung, E., J.P. Mordes, A.A. Rossini & D.L. Greiner. 2003. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J. Clin. Invest. 112 : 795.
2. Thornley, T.B., M.A. Brehm, T.G. Markees, et al. 2006. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J. Immunol. 176 : 1561.
3. Yamazaki, M., T. Pearson, M.A. Brehm, et al. 2007. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Am. J. Transplant 7 : 1710.
4. Thornley, T.B., N.E. Phillips, B.C. Beaudette-Zlatanova, et al. 2007. Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J. Immunol. 179 : 6620.