In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography

Artificial Organs

Volumn 33, Issue 2, 2009, Pages 164-168

  Urakami, Takeo ^a   Kawaguchi, Akira T ^b   Akai, Shuji ^a   Hatanaka, Kentaro ^a   Koide, Hiroyuki ^a   Shimizu, Kosuke ^a   Asai, Tomohiro ^a   Fukumoto, Dai ^c   Harada, Norihiro ^c   Tsukada, Hideo ^c   Oku, Naoto ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CENTRAL RESEARCH LABORATORY   (Japan)

Author keywords

Brain ischemia; Drug delivery system; Liposome encapsulated hemoglobin; Pharmacokinetics; Positron emission tomography

Indexed keywords

CONTROLLED DRUG DELIVERY; ELECTRONS; FLOW PATTERNS; NANOPARTICLES; OXYGEN; POSITRONS; TARGETED DRUG DELIVERY;

ARTIFICIAL OXYGEN CARRIER; BIODISTRIBUTIONS; BRAIN ISCHEMIA; DRUG-DELIVERY SYSTEMS; IMAGING TECHNOLOGY; IN-VIVO; ISCHAEMIA; LIPOSOME ENCAPSULATED HEMOGLOBINS; NON-INVASIVE IMAGING; POSITRON EMITTERS;

POSITRON EMISSION TOMOGRAPHY;

FLUORINE 18; HEMOGLOBIN; LIPOSOME; NANOPARTICLE; TRM 645; UNCLASSIFIED DRUG; WATER O 15;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG LABELING; ENCAPSULATION; IN VIVO STUDY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT;

ANIMALIA; RATTUS; RODENTIA;

EID: 57749185892     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2008.00702.x     Document Type: Article

References (16)

1. Adler-Moore J. AmBisome targeting to fungal infections. Bone Marrow Transplant 1994 14 (Suppl. 5 S3 7.
2. Minko T, Pakunlu RI, Wang Y, Khandare JJ, Saad M. New generation of liposomal drugs for cancer. Anticancer Agents Med Chem 2006 6 : 537 52.
3. Pedroso de Lima MC, Neves S, Filipe A, Duzgunes N, Simoes S. Cationic liposomes for gene delivery: from biophysics to biological applications. Curr Med Chem 2003 10 : 1221 31.
4. Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. Review of hemoglobin-vesicles as artificial oxygen carriers. Artif Organs 2009 33 : 139 45.
5. Kaneda S, Ishizuka T, Goto H, Kimura T, Inaba K, Kasukawa H. Liposome-encapsulated hemoglobin, TRM-645: current status of the development and important issues for clinical application. Artif Organs 2009 33 : 146 52.
6. Buchan P. Smarter candidate selection - utilizing microdosing in exploratory clinical studies. Ernst Schering Res Found Workshop 2007 59 : 7 27.
7. Bergstrom M, Grahnen A, Langstrom B. Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development. Eur J Clin Pharmacol 2003 59 : 357 66.
8. 18F]-radiolabeling preformed liposomes, and determination of liposomal trafficking by positron emission tomography. J Med Chem 2007 50 : 6454 7.
9. Takamatsu H, Kondo K, Ikeda Y, Umemura K. Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion. Eur J Pharmacol 1998 362 : 137 42.
10. Mizuta T, Kitamura K, Iwata H, et al. Performance evaluation of a high-sensitivity large-aperture small animal PET scanner: clairvivo PET. Ann Nucl Med 2008 22 : 447 55.
11. Oku N, Tokudome Y, Tsukada H, Kosugi T, Namba Y, Okada S. In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography. Biopharm Drug Dispos 1996 17 : 435 41.
12. Oku N, Tokudome Y, Tsukada H, Okada S. Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography. Biochim Biophys Acta 1995 1238 : 86 90.
13. F]FDP). Nucl Med Biol 2007 34 : 165 71.
14. Kawaguchi AT, Fukumoto D, Haida M, Ogata Y, Yamano M, Tsukada H. Liposome-encapsulated hemoglobin reduces the size of cerebral infarction in the rat: evaluation with photochemically induced thrombosis of the middle cerebral artery. Stroke 2007 38 : 1626 32.
15. 2 carrier after brain ischemia and reperfusion in the primate Abstract Stroke 2007 38 : 599.
16. Awasthi V, Yee SH, Jerabek P, Goins B, Phillips WT. Cerebral oxygen delivery by liposome-encapsulated hemoglobin: a positron-emission tomographic evaluation in a rat model of hemorrhagic shock. J Appl Physiol 2007 103 : 28 38.