How influenza virus is locked out of the cell

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 48, 2008, Pages 18647-18648

  Modis, Yorgo ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; DISOXARIL; ENFUVIRTIDE; OSELTAMIVIR; PLECONARIL; PROTEIN VP1; TERT BUTYLHYDROQUINONE; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN; VIRUS HEMAGGLUTININ;

BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG BINDING SITE; DRUG CONFORMATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; INFLUENZA; INFLUENZA VIRUS; MEMBRANE FUSION; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS VIRULENCE;

HEMAGGLUTININS, VIRAL; HUMANS; HYDROQUINONES; MODELS, MOLECULAR; ORTHOMYXOVIRIDAE; PROTEIN CONFORMATION; VIRUS INTERNALIZATION;

ORTHOMYXOVIRIDAE;

EID: 57749122074     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810508106     Document Type: Note

References (12)

1. Kilby JM, et al. (1998) Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nat Med 4:1302-1307.
2. Russell RJ, et al. (2008) Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci USA 105:17736-17741.
3. Harrison SC (2008) Viral membrane fusion. Nat Struct Mol Biol 15:690-698.
4. Skehel JJ, Wiley DC (2000) Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin. Annu Rev Biochem 69:531-569.
5. Yu KL, et al. (2002) Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5- hydroxy-cyclohexylmethylamine. Bioorg Med Chem Lett 12:3379-3382.
6. Bodian DL, et al. (1993) Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochemistry 32:2967-2978.
7. Hoffman LR, Kuntz ID, White JM (1997) Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: Irreversible inhibition of infectivity. J Virol 71:8808-8820.
8. Hadfield AT, Diana GD, Rossmann MG (1999) Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16. Proc Natl Acad Sci USA 96:14730-14735.
9. Smith TJ, et al. (1986) The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science 233:1286-1293.
10. Modis Y, Ogata S, Clements D, Harrison SC (2003) A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci USA 100:6986-6991.
11. Modis Y, Ogata S, Clements D, Harrison SC (2004) Structure of the dengue virus envelope protein after membrane fusion. Nature 427:313-319.
12. Ilyushina NA, Bovin NV, Webster RG, Govorkova EA (2006) Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants. Antiviral Res 70:121-131.