Discovery and optimisation of a potent and selective tertiary sulfonamide oxytocin antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 2, 2009, Pages 528-532

  Barton, Nicholas P ^a   Bellenie, Benjamin R ^a   Doran, Andrew T ^a   Emmons, Amanda J ^a   Heer, Jag P ^a   Salvagno, Cristian M ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GSK   (Italy)

Author keywords

HTS; Oxytocin; Pharmacophore

Indexed keywords

OXYTOCIN ANTAGONIST; SULFONAMIDE;

ANIMAL EXPERIMENT; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ANALYSIS; UTERUS CONTRACTION;

ADMINISTRATION, ORAL; DRUG DISCOVERY; MODELS, MOLECULAR; OXYTOCIN; SULFONAMIDES;

EID: 57749115653     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.018     Document Type: Article

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