HFE variants, APOE and Alzheimer's disease: Findings from the population-based Rotterdam Study

Neurobiology of Aging

Volumn 30, Issue 2, 2009, Pages 330-332

  Alizadeh, B Z ^a   Njajou, O T ^a   Millan M R ^a   Hofman, A ^a   Breteler, M M ^a   van Duijn, C M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer's disease; C282Y; H63D; Hemochromatosis; HFE; Iron

Indexed keywords

APOLIPOPROTEIN E; HFE PROTEIN;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; ONSET AGE; PATHOGENESIS; POPULATION RESEARCH; PRIORITY JOURNAL; SEX DIFFERENCE;

AGE DISTRIBUTION; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INCIDENCE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS;

EID: 57749093578     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.05.026     Document Type: Article

References (4)

1. Berlin D., Chong G., Chertkow H., Bergman H., Phillips N.A., and Schipper H.M. Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI. Neurobiol. Aging 25 (2004) 465-474 (see also [S1])
2. Bertram L., McQueen M.B., Mullin K., Blacker D., and Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39 (2007) 17-23 (see also [S2])
3. Guerreiro R.J., Bras J.M., Santana I., Januario C., Santiago B., Morgadinho A.S., Ribeiro M.H., Hardy J., Singleton A., and Oliveira C. Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. BMC Neurol. 6 (2006) 24 (see also [S9])
4. Sampietro M., Caputo L., Casatta A., Meregalli M., Pellagatti A., Tagliabue J., Annoni G., and Vergani C. The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease. Neurobiol. Aging 22 (2001) 563-568 (see also [S23])