Reduction with dithiothreitol causes serglycin-specific defects in secretory granule integrity of bone marrow derived mast cells

Molecular Immunology

Volumn 46, Issue 3, 2009, Pages 422-428

  Braga, Tiago ^a   Ringvall, Maria ^b   Tveit, Heidi ^c   Åbrink, Magnus ^b   Pejler, Gunnar ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Intracellular sorting; Mast cells; Proteoglycans; Secretory granule; Serglycin

Indexed keywords

CARBOXYPEPTIDASE A; DITHIOTHREITOL; PROTEIN SERGLYCIN; PROTEOGLYCAN; SULFATE; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL VIABILITY; CONTROLLED STUDY; MAST CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEOGLYCAN SYNTHESIS; REDUCTION; SECRETORY GRANULE; TRANSMISSION ELECTRON MICROSCOPY;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW CELLS; CELL SHAPE; DITHIOTHREITOL; MAST CELLS; MICE; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDE HYDROLASES; PROTEOGLYCANS; SECRETORY VESICLES; VESICULAR TRANSPORT PROTEINS;

EID: 57749092644     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.10.019     Document Type: Article

References (27)

1. Åbrink M., Grujic M., and Pejler G. Serglycin is essential for maturation of mast cell secretory granule. J. Biol. Chem. 279 (2004) 40897-40905
2. Blank U., and Rivera J. The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol. 25 (2004) 266-273
3. Braga T., Grujic M., Lukinius A., Hellman L., Abrink M., and Pejler G. Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem. J. 403 (2007) 49-57
4. Chanat E., Weiss U., Huttner W.B., and Tooze S.A. Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-golgi network causes its missorting to the constitutive secretory pathways. EMBO J. 12 (1993) 2159-2168
5. Cool D.R., Fenger M., Snell C.R., and Loh Y.P. Identification of the sorting signal motif within pro-opiomelanocortin for the regulated secretory pathway. J. Biol. Chem. 270 (1995) 8723-8729
6. Coussens L.M., Raymond W.W., Bergers G., Laig-Webster M., Behrendtsen O., Werb Z., Caughey G.H., and Hanahan D. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13 (1999) 1382-1397
7. Echtenacher B., Mannel D.N., and Hultner L. Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381 (1996) 75-77
8. Galli S.J., Kalesnikoff J., Grimbaldeston M.A., Piliponsky A.M., Williams C.M., and Tsai M. Mast cells as "tunable" effector and immunoregulatory cells: Recent advances. Annu. Rev. Immunol. 23 (2005) 749-786
9. Galli S.J., Nakae S., and Tsai M. Mast cells in the development of adaptive immune responses. Nat. Immunol. 6 (2005) 135-142
10. Gordon J.R., and Galli S.J. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature 346 (1990) 274-276
11. Grujic M., Braga T., Lukinius A., Eloranta M.L., Knight S.D., Pejler G., and Abrink M. Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J. Biol. Chem. 280 (2005) 33411-33418
12. Ha T.Y., Reed N.D., and Crowle P.K. Delayed expulsion of adult Trichinella spiralis by mast cell-deficient W/Wv mice. Infect. Immun. 41 (1983) 445-447
13. Henningsson F., Hergeth S., Cortelius R., Åbrink M., and Pejler G. A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J. 273 (2006) 4901-4912
14. Kolset S.O., Prydz K., and Pejler G. Intracellular proteoglycans. Biochem. J. 379 (2004) 217-227
15. Kolset S.O., and Tveit H. Serglycin-structure and biology. Cell Mol. Life Sci. 65 (2008) 1073-1085
16. Kromer A., Glombik M.M., Huttner W.B., and Gerdes H.H. Essential role of the disulfide-bonded loop of chromogranin B for sorting to secretory granules is revealed by expression of a deletion mutant in the absence of endogenous granin synthesis. J. Cell Biol. 140 (1998) 1331-1346
17. Lee D.M., Friend D.S., Gurish M.F., Benoist C., Mathis D., and Brenner M.B. Mast cells: A cellular link between autoantibodies and inflammatory arthritis. Science 297 (2002) 1689-1692
18. Malaviya R., Ikeda T., Ross E., and Abraham S.N. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha [see comments]. Nature 381 (1996) 77-80
19. Niemann C.U., Abrink M., Pejler G., Fischer R.L., Christensen E.I., Knight S.D., and Borregaard N. Neutrophil elastase depends on serglycin proteoglycan for localization in granules. Blood 109 (2007) 4478-4486
20. Pejler G., Abrink M., Ringvall M., and Wernersson S. Mast cell proteases. Adv. Immunol. 95 (2007) 167-255
21. Ringvall M., Ronnberg E., Wernersson S., Duelli A., Henningsson F., Abrink M., Garcia-Faroldi G., Fajardo I., and Pejler G. Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan. J. Allergy Clin. Immunol. 121 (2008) 1020-1026
22. Secor V.H., Secor W.E., Gutekunst C.A., and Brown M.A. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J. Exp. Med. 191 (2000) 813-822
23. Soucek L., Lawlor E.R., Soto D., Shchors K., Swigart L.B., and Evan G.I. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat. Med. 13 (2007) 1211-1218
24. Turner H., and Kinet J.P. Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 402 (1999) B24-30
25. Woulfe D.M., Lilliendahl J.K., August S., Rauova L., Kowalska A., Åbrink M., Pejler G., White J.G., and Schick B.P. Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood 111 (2008) 3458-3467
26. Yu M., Tsai M., Tam S.Y., Jones C., Zehnder J., and Galli S.J. Mast cells can promote the development of multiple features of chronic asthma in mice. J. Clin. Invest. 116 (2006) 1633-1641
27. Zernichow L., Abrink M., Hallgren J., Grujic M., Pejler G., and Kolset S.O. Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J. Biol. Chem. 281 (2006) 26792-26801