Embryonic lung growth is normal in a cftr-knockout mouse model

Experimental Lung Research

Volumn 34, Issue 10, 2008, Pages 717-727

  Wallace, Helen L ^a   Connell, Marilyn G ^a   Losty, Paul D ^a   Jesudason, Edwin C ^a   Southern, Kevin W ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Airway peristalsis; Airway smooth muscle; CFTR; Embryonic lung growth

Indexed keywords

TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL TISSUE; ARTICLE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; FETUS LUNG; GENOTYPE; KNOCKOUT MOUSE; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; MESENCHYME; MITOSIS; MOUSE; NONHUMAN; PERISTALSIS; PRIORITY JOURNAL; SMOOTH MUSCLE; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; LUNG; MICE; MICE, INBRED CFTR; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE;

EID: 57749087873     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140802389719     Document Type: Article

References (27)

1. Pitkanen OM, O'Brodovich HM: Significance of ion transport during lung development and in respiratory disease of the newborn. Ann Med. 1998;30:134-142.
2. Warburton D, Zhao J, Berberich MA, Bernfield M: Molecular embryology of the lung: then, now, and in the future. Am J Physiol. 1999;276:L697-L704.
3. Harding R, Hooper SB: Regulation of lung expansion and lung growth before birth. J Appl Physiol. 1996;81:209-224.
4. Moessinger AC, Harding R, Adamson TM, Singh M, Kiu GT: Role of lung fluid volume in growth and maturation of the fetal sheep lung. Clin Invest. 1990;86:1270-1277.
5. Alcorn D, Adamson TM, Lambert TF, Maloney JE, Ritchie BC, Robinson PM: Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung. J Anat. 1977;123:649-660.
6. Carmel JA, Friedman F, Adams FH: Fetal tracheal ligation and lung development. Am J Dis Child. 1965;109:452-456.
7. Jesudason EC, Smith NP, Connell MG, Spiller DG, White MR, Fernig DG, Losty PD: Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis. Am J Respir Cell Mol Biol. 2005;32:118-127.
8. Jesudason EC, Smith NP, Connell MG, Spiller DG, White MR, Fernig DG, Losty PD: Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth. Am J Physiol Lung Cell Mol Physiol. 2006;291:L559-L565.
9. Schittny JC, Miserocchi G, Sparrow MP: Spontaneous peristaltic airway contractions propel lung liquid through the bronchial tree of intact and fetal lung explants. Am J of Resp Cell Mol Biol. 2000;23:11-18.
10. Featherstone NC, Connell MG, Fernig DG, Wray S, Burdyga TV, Losty PD, Jesudason EC: Airway smooth muscle dysfunction precedes teratogenic congenital diaphragmatic hernia and may contribute to hypoplastic lung morphogenesis. Am J Resp Cell Mol Biol. 2006;35:571-578.
11. Mailleux AA, Kelly R, Veltmaat JM, De Langhe SP, Zaffran S, Thiery JP, Bellusci S: Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 2005;132:2157-2166.
12. Featherstone NC, Jesudason EC, Connell MG, Fernig DG, Wray S, Losty PD, Burdyga TV: Spontaneous propagating calcium waves underpin airway peristalsis in embryonic rat lung. Am J Resp Cell Mol Biol. 2005;33:153-160.
13. Olver RE, Strang LB: Ion fluxes across the pulmonary epithelium and the secretion of lung liquid in the foetal lamb. J Physiol. 1974;241:327-357.
14. Olver RE, Walters DV, S MW: Developmental regulation of lung liquid transport. Annu Rev Physiol. 2004;66:77-101.
15. Anderson MP, Rich DP, Gregory RJ, Smith AE, Welsh MJ: Generation of cAMP-activated chloride currents by expression of CFTR. Science 1991;251:679-682.
16. Boucher RC: Cystic Fibrosis:a disease of vulnerability to airway surface dehydration. Trends Mol Med. 2007;13:231-240.
17. Boucher RC: New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J. 2004;23:146-158.
18. Gill D LJ: Function of CFTR protein: developmental Role. Prog Resp Res. 1996;34:54-60.
19. Cohen JC, Larson JE: Cystic fibrosis transmembrane conductance regulator (CFTR) dependent cytoskeletal tension during lung organogenesis. Dev Dyn. 2006;235:2736-2748.
20. Larson JE, Cohen JC: Improvement of pulmonary hypoplasia associated with congenital diaphragmatic hernia by in utero CFTR gene therapy. Am J Physiol Lung Cell Mol Physiol. 2006;291:L4-L10.
21. Larson JE, Morrow SL, Happel L, Sharp JF, Cohen JC: Reversal of cystic fibrosis phenotype in mice by gene therapy in utero. Lancet. 1997;349:619-620.
22. Pan J, Luk C, Kent G, Cutz E, Yeger H: Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Resp Cell Mol Biol. 2006;35:320-326.
23. Broackes-Carter FC, Mouchel N, Gill D, Hyde S, Bassett J, Harris A: Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy. Hum Mol Genet. 2002;11:125-131.
24. Larson JE, Delcarpio JB, Farberman MM, Morrow SL, Cohen JC: CFTR modulates lung secretory cell proliferation and differentiation. Am J Physiol Lung Cell Mol Physiol. 2000;279:L333-L341.
25. Jesudason EC, Connell MG, Fernig DG, Lloyd DA, Losty PD: Early lung malformations in congenital diaphragmatic hernia. J Pediatr Surg. 2000;35:124-127; discussion 128.
26. Zhou L, Graeff RW, McCray PB Jr, Simonet WS, Whitsett JA: Keratinocyte growth factor stimulates CFTR-independent fluid secretion in the fetal lung in vitro. Am J Physiol. 1996;271:L987-994.
27. Barker PM, Brigman KK, Paradiso AM, Boucher RC, Gatzy JT: Cl secretion by trachea of CFTR (+/-) and (-/-) fetal mouse. Am J Resp Cell Mol Biol. 1995;13:307-313.