Unilateral intracarotid injection of holmium microspheres to induce bilateral MRI-validated cerebral embolization in rats

Journal of Neuroscience Methods

Volumn 176, Issue 2, 2009, Pages 152-156

  de Lange, Fellery ^a   Dieleman, Jan M ^a   Blezer, Erwin L A ^b   Houston, Ralph J F ^a   Kalkman, Cor J ^a   Nijsen, J Frank W ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Animal model; Cerebral embolization; Holmium; Microspheres; MRI; Rat

Indexed keywords

HOLMIUM; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN EMBOLISM; CAROTID ARTERY; CONTROLLED STUDY; HEMISPHERE; HISTOPATHOLOGY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; CAROTID ARTERIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FUNCTIONAL LATERALITY; HOLMIUM; INJECTIONS, INTRA-ARTERIAL; INTRACRANIAL EMBOLISM; MAGNETIC RESONANCE IMAGING; MALE; MICROSPHERES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS;

EID: 57649240452     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2008.09.011     Document Type: Article

References (18)

1. Aspey B.S., Taylor F.L., Terruli M., and Harrison M.J.G. Temporary middle cerebral artery occlusion in the rat: consistent protocol for a model of stroke and reperfusion. Neuropathol Appl Neurobiol 26 (2000) 232-242
2. Beauchamp Jr. N.J., Barker P.B., Wang P.Y., and vanZijl P.C.M. Imaging of acute cerebral ischemia. Radiology 212 (1999) 307-324
3. Bralet J., Beley P., Bralet A.M., and Beley A. Influence of various agents on the development of brain edema in the rat following microembolism. Protective effect of gamma-butyrolactone. Stroke 10 (1979) 653-656
4. de Ley G., Nshimyumuremyi J.B., and Leusen I. Hemispheric blood flow in the rat after unilateral common carotid occlusion: evolution with time. Stroke 16 (1985) 69-73
5. Gerriets T., Stolz E., Walberer M., Muller C., Rottger C., Kluge A., et al. Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography. Stroke 35 (2004) 2372-2377
6. Gulati O.P., Sharma S.C., and Hammersen F. Hemodynamic, biochemical and morphological changes in the dextran and d-galactosamine-induced edemas in rats. Arch Int Pharmacodyn Ther 263 (1983) 272-287
7. Kogure K., Ishizaki M., Nemoto M., Nakamura T., and Suzuki M. Antishock effects of corticosterone on dextran-induced shock in rats. Am J Physiol Endocrinol Metab 251 (1986) E569-E575
8. Lee R.M.K.W. Morphology of cerebral arteries. Pharmacol Ther 66 (1995) 149-173
9. Mayzel-Oreg O., Omae T., Kazemi M., Li F., Fisher M., Cohen Y., et al. Microsphere-induced embolic stroke: an MRI study. Magn Reson Med 51 (2004) 1232-1238
10. Miyake K., Takeo S., and Kaijihara H. Sustained decrease in brain regional blood flow after microsphere embolism in rats. Stroke 24 (1993) 415-420
11. Morita Y., Fukuuchi Y., Koto A., Suzuki N., Isozumi K., Gotoh J., et al. Rapid changes in pial arterial diameter and cerebral blood flow caused by ipsilateral carotid artery occlusion in rats. Keio J Med 46 (1997) 120-127
12. Nijsen J.F., van Steenbergen M.J., Kooijman H., Talsma H., Kroon-Batenburg L.M., van De W.M., et al. Characterization of poly(l-lactic acid) microspheres loaded with holmium acetylacetonate. Biomaterials 22 (2001) 3073-3081
13. Nijsen J.F.W., Seppenwoolde J.H., Havenith T., Bos C., Bakker C.J.G., and het Schip A.D. Liver tumors: MR imaging of radioactive holmium microspheres-phantom and rabbit study. Radiology 231 (2004) 491-499
14. Omae T., Mayzel-Oreg O., Li F., Sotak C.H., and Fisher M. Inapparent hemodynamic insufficiency exacerbates ischemic damage in a rat microembolic stroke model. Stroke 31 (2000) 2494-2499
15. Takagi N., Miyake K., Taguchi T., Tamada H., Takagi K., Sugita N., et al. Failure in learning task and loss of cortical cholingergic fibers in microsphere-embolized rats. Exp Brain Res 114 (1997) 279-287
16. Takeo S., Taguchi T., Tanonaka K., Miyake K., Horiguchi T., Takagi N., et al. Sustained damage to energy metabolism of brain regions after microsphere embolism in rats. Stroke 23 (1992) 62-68
17. Zielhuis S.W., Nijsen J.F., de Roos R., Krijger G.C., van Rijk P.P., Hennink W.E., et al. Production of GMP-grade radioactive holmium loaded poly(l-lactic acid) microspheres for clinical application. Int J Pharm 311 (2006) 69-74
18. Zivin J.A., DeGirolami U., Kochhar A., Lyden P.D., Mazzarella V., Hemenway C.C., et al. A model for quantitative evaluation of embolic stroke therapy. Brain Res 435 (1987) 305-309