A comparison study of a recombinant tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) and methotrexate in treatment of patients with active rheumatoid arthritis in China

Rheumatology International

Volumn 29, Issue 3, 2009, Pages 297-303

  Hu, Dawei ^a   Bao, Chunde ^a   Chen, Shunle ^a   Gu, Jieruo ^b   Li, Zhanguo ^c   Sun, Lingyun ^d   Han, Xinghai ^e   Ni, Liqing ^f  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^d MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^e SECOND MILITARY MEDICAL UNIVERSITY   (China)

^f Guanghua Rheumatology Hospital   (China)

Author keywords

Methotrexate; Recombinant fusion protein; Rheumatoid arthritis; Tumor necrosis factor

Indexed keywords

ETANERCEPT; METHOTREXATE; PLACEBO;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALOPECIA; ARTICLE; BLOOD PRESSURE; CHINA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ACTIVITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DYSPEPSIA; EDEMA; EVALUATION; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INFECTION; INJECTION SITE REACTION; INSOMNIA; LEUKOPENIA; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RHEUMATOID ARTHRITIS; SIDE EFFECT; THORAX PAIN; TREATMENT DURATION; TREATMENT RESPONSE; UPPER RESPIRATORY TRACT INFECTION; VISUAL DISORDER;

ADMINISTRATION, ORAL; ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CHINA; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, SUBCUTANEOUS; MALE; METHOTREXATE; MIDDLE AGED; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 57649228546     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-008-0681-x     Document Type: Article

References (16)

1. M Feldmann FM Brennan RN Maini 1996 The role of cytokines in rheumatoid arthritis Ann Rev Immunol 14 397 440
2. J Braunstein J Allendorf M Reister 1994 How are soluble forms of ICAM-1 (sCD54) and LFA-3 (sCD58) generated? Immunobiology 340 253 259
3. PH Wooley J Dutcher MB Widmer 1993 Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice J Immunol 151 6602
4. LW Moreland SW Baumgartner MH Schiff 1997 Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein New Eng J Med 337 141 147
5. American College of Rheumatology (1996) Ad Hoc Committee on Clinical Guidelines: Guidelines for the management of rheumatoid arthritis. Arthritis Rheum 39:713
6. DT Felson JJ Anderson M Boers 1995 American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis Arthritis Rheum 6 727
7. DT Felson JJ Anderson M Boers 1995 Preliminary definition of improvement in rheumatoid arthritis Arthritis Rheum 38 727 735
8. KG Saag R Koehnke JR Caldwell 1994 Low dose long term corticosteroid therapy in rheumatoid arthritis: an analysis of serious adverse events Am J Med 96 115 116
9. LS Simm 1993 Nonsteroidal anti-inflammatory drug toxicity Curr Opin Rheumatol 5 265
10. JM Cash JH Klippel 1994 Second-line drug therapy for rheumatoid arthritis N Engl J Med 330 1368
11. A Grom KF Murray L Luyrink 1996 Patterns of expression of tumor necrosis factor α, tumor necrosis factor β, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondyloarthropathy Arthritis Rheum 39 1703
12. GS Firestein NJ Zvaifler 1997 Anticytokine therapy in rheumatoid arthritis N Engl J Med 337 195 197
13. JM Bathon RW Martin RM Fleischmann 2000 A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis New Eng J Med 343 1586 1593
14. LW Moreland SB Cohen SW Baumgartner 2001 Long-term safety and efficacy of etanercept in patients with rheumatoid arthritis J Rheumatol 28 1238 1244
15. M Fusconi A Vannini AC Dall'aglio 2007 Etanercept and infliximab induce the same serological autoimmune modifications in patients with rheumatoid arthritis Rheumatol Int 28 1 47 49
16. ME Weinblatt JM Kremer A Bankhurst 1999 A trial of etanercept: a recombinant tumor necrosis factor receptor:Fc fusion protein in patients with rheumatoid arthritis receiving methotrexate New Eng J Med 340 253 259