An integrated experimental-computational approach for the study of engineered cartilage constructs subjected to combined regimens of hydrostatic pressure and interstitial perfusion

Bio-Medical Materials and Engineering

Volumn 18, Issue 4-5, 2008, Pages 273-278

  Moretti, M ^a,b   Freed, L E ^b   Padera, R F ^d   Lagana K ^c   Boschetti, F ^c   Raimondi, M T ^a,c  

^a IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c POLITECNICO DI MILANO   (Italy)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; BIOREACTOR DESIGN; CALF (BOVINE); CARTILAGE; CARTILAGE CELL; COMPUTATIONAL FLUID DYNAMICS; CONFERENCE PAPER; CONTROLLED STUDY; HYDROSTATIC PRESSURE; INTERSTITIUM; NONHUMAN; PERFUSION; PRIORITY JOURNAL; SHEAR STRESS; TISSUE ENGINEERING;

ANIMALS; BIOREACTORS; CARTILAGE; CATTLE; CELLS, CULTURED; CHONDROCYTES; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; MECHANOTRANSDUCTION, CELLULAR; ORGAN CULTURE TECHNIQUES; PERFUSION; PRESSURE; SYSTEMS INTEGRATION; TISSUE ENGINEERING;

EID: 57649218795     PISSN: 09592989     EISSN: None     Source Type: Journal    
DOI: 10.3233/BME-2008-0536     Document Type: Conference Paper

References (6)

1. T. Davisson, R.L. Sah and A. Ratcliffe, Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures, Tissue Eng. 8(5) (2002), 807-816.
2. P. Angele, J.U. Yoo, C. Smith, J. Mansour, K.J. Jepsen, M. Nerlich and B. Johnstone, Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro, J. Orthop. Res. 21(3) (2003), 451-457.
3. R. Wenger et al., Hydrostatic pressure increases apoptosis in cartilage constructs produced from human osteoarthritic chondrocytes, Front Biosci. 11 (2006), 1690-1695.
4. M.T. Raimondi, Engineered tissue as a model to study cell and tissue function from a biophysical perspective, Curr. Drug Discov. Technol. 3(4) (2006), 245-268.
5. K. Laganà, M. Moretti, G. Dubini and M.T. Raimondi, A new bioreactor for the controlled application of complex mechanical stimuli for cartilage tissue engineering, Proc. Inst. Mech. Eng. H 222(5) (2008), 705-715.
6. M.T. Raimondi et al., Mechanobiology of engineered cartilage cultured under a quantified fluid-dynamic environment, Biomech. Model. Mechanobiol. 1 (2002), 69-82.