Chronic stress, combined with a high-fat/high-sugar diet, shifts sympathetic signaling toward neuropeptide Y and leads to obesity and the metabolic syndrome

Annals of the New York Academy of Sciences

Volumn 1148, Issue , 2008, Pages 232-237

  Kuo, Lydia E ^a   Czarnecka, Magdalena ^a   Kitlinska, Joanna B ^a   Tilan, Jason U ^a   Kvetňanský, Richard ^b   Zukowska, Zofia ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

Adipogenesis; Angiogenesis; Metabolic syndrome; Neuropeptide Y; Obesity; Stress; Sympathetic system; Y2 receptors

Indexed keywords

DEXAMETHASONE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y2 RECEPTOR;

ABDOMINAL OBESITY; ADENOVIRUS; ADIPOGENESIS; ADIPOSE TISSUE; ADRENERGIC SYSTEM; AGGRESSION; ANGIOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC STRESS; CONFERENCE PAPER; ENDOTHELIUM CELL; FATTY LIVER; GENE EXPRESSION; GLUCOSE INTOLERANCE; HYPERINSULINEMIA; HYPERLIPIDEMIA; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTRAABDOMINAL FAT; LIPID DIET; METABOLIC SYNDROME X; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; OBESITY; PROADIPOCYTE; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SUGAR INTAKE; SYMPATHETIC NERVE CELL; SYMPTOMATOLOGY; WHITE ADIPOSE TISSUE;

MUS;

EID: 57649217286     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1410.035     Document Type: Conference Paper

References (23)

1. Dallman, M.F. et al. 2003. Chronic stress and obesity: a new view of "comfort food." Proc. Natl. Acad. Sci. USA 100 : 11696 11701.
2. Ludwig, D.S. 2003. Novel treatments for obesity. Asia. Pac. J. Clin. Nutr. 12 (Suppl S8.
3. Michel, C. et al. 2005. Chronic stress reduces body fat content in both obesity-prone and obesity-resistant strains of mice. Horm. Behav. 48 : 172 179.
4. Kuo, L.E. et al. 2007. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat. Med. 13 : 803 811.
5. Mikurube, H. et al. 2005. Association of change in the type of job with prevalence of components of the metabolic syndrome: special reference to job stress. Nippon. Koshu. Eisei. Zasshi. 52 : 987 993.
6. Dodt, C. et al. 2003. Sympathetic control of white adipose tissue in lean and obese humans. Acta Physiol. Scand. 177 : 351 357.
7. Bjorntorp, P. 2001. Do stress reactions cause abdominal obesity and comorbidities? Obes. Rev. 2 : 73 86.
8. Turtzo, L.C. & M.D. Lane. 2002. Completing the loop: neuron-adipocyte interactions and the control of energy homeostasis. Horm. Metab. Res. 34 : 607 615.
9. Zukowska-Grojec, Z. 1995. Neuropeptide Y: a novel sympathetic stress hormone and more. Ann. N. Y. Acad. Sci. 771 : 219 233.
10. Zukowska-Grojec, Z., E.S. Marks & M. Haass. 1987. Neuropeptide Y is a potent vasoconstrictor and a cardiodepressant in rat. Am. J. Physiol. 253 : H1234 H1239.
11. Kalra, S.P. & P.S. Kalra. 2004. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38 : 201 211.
12. Mashiko, S. et al. 2003. Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY. Endocrinology 144 : 1793 1801.
13. Chronwall, B.M. & Z. Zukowska. 2004. Neuropeptide Y, ubiquitous and elusive. Peptides 25 : 359 363.
14. Turtzo, L.C., R. Marx & M.D. Lane. 2001. Cross-talk between sympathetic neurons and adipocytes in coculture. Proc. Natl. Acad. Sci. USA. 98 : 12385 12390.
15. Rybkin, II. et al. 1997. Effect of restraint stress on food intake and body weight is determined by time of day. Am. J. Physiol. 273 : R1612 R1622.
16. Myrsen-Axcrona, U., B. Ahren & F. Sundler. 1999. Modulatory role of adrenergic nerves on dexamethasone-induced islet cell NPY expression in the rat: evidence from chemical sympathectomy. Pancreas 18 : 180 188.
17. Myrsen-Axcrona, U. et al. 1997. Dexamethasone induces neuropeptide Y (NPY) expression and impairs insulin release in the insulin-producing cell line RINm5F: release of NPY and insulin through different pathways. J. Biol. Chem. 272 : 10790 10796.
18. Allen, J.M., J.B. Martin & G. Heinrich. 1987. Neuropeptide Y gene expression in PC12 cells and its regulation by nerve growth factor: a model for developmental regulation. Brain Res. 427 : 39 43.
19. Lee, E.W. et al. 2003. Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. J. Clin. Invest. 111 : 1853 1862.
20. Kitlinska, J. et al. 2005. Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Res. 65 : 1719 1728.
21. Li, L. et al. 2003. Neuropeptide Y-induced acceleration of postangioplasty occlusion of rat carotid artery. Arterioscler. Thromb. Vasc. Biol. 23 : 1204 1210.
22. Karvonen, M.K. et al. 2001. Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men. Atherosclerosis 159 : 145 151.
23. Lavebratt, C. et al. 2006. Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men. Int. J. Obes. (Lond.) 30 : 453 459.