A novel peptide binding to the cytoplasmic domain of class A scavenger receptor reduces lipid uptake in THP-1 macrophages

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1791, Issue 1, 2009, Pages 76-83

  Wang, Xiaohua ^a   Zheng, Yuan ^a   Xu, Yiming ^a   Ben, Jingjing ^a   Gao, Song ^a   Zhu, Xudong ^a   Zhuang, Yan ^a   Yue, Shen ^a   Bai, Hui ^a   Chen, Yaoyu ^a   Jiang, Li ^a   Ji, Yong ^a   Xu, Yong ^a   Fan, Leming ^a   Sha, Jiahao ^a   He, Zhigang ^b   Chen, Qi ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Acetylated low density lipoprotein (AcLDL); Atherosclerosis; Class A scavenger receptor (SR A); Cytoplasmic domain; Foam cell; Phage peptide library

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; H11 PEPTIDE; HEAT SHOCK PROTEIN 22; HYBRID PROTEIN; LOW DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 9; PEPTIDE; PEPTIDE LIBRARY; SCAVENGER RECEPTOR A; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL STRAIN THP 1; CONTROLLED STUDY; CYTOPLASM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPID STORAGE; LIPID TRANSPORT; MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CELL LINE; HUMANS; LIPID METABOLISM; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE 9; PEPTIDE LIBRARY; PEPTIDES; RECOMBINANT FUSION PROTEINS; SCAVENGER RECEPTORS, CLASS A; SIGNAL TRANSDUCTION;

EID: 57649184412     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2008.10.011     Document Type: Article

References (34)

1. Li A.C., and Glass C.K. The macrophage foam cell as a target for therapeutic intervention. Nat. Med. 8 (2002) 1235-1242
2. Gough P.J., and Gordon S. The role of scavenger receptors in the innate immune system. Microbes Infect. 2 (2000) 305-311
3. Libby P., Ridker P.M., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
4. Saxon L.A., Bristow M.R., Boehmer J., Krueger S., Kass D.A., De Marco T., Carson P., DiCarlo L., Feldman A.M., Galle E., and Ecklund F. Predictors of sudden cardiac death and appropriate shock in the comparison of medical therapy, pacing, and defibrillation in heart failure (COMPANION) trial. Circulation 114 (2006) 2766-2772
5. Stary H.C., Chandler A.B., Glagov S., Guyton J.R., Insull Jr. W., Rosenfeld M.E., Schaffer S.A., Schwartz C.J., Wagner W.D., and Wissler R.W. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 89 (1994) 2462-2478
6. Deguchi J.O., Aikawa M., Tung C.H., Aikawa E., Kim D.E., Ntziachristos V., Weissleder R., and Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation 114 (2006) 55-62
7. Krieger M., and Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63 (1994) 601-637
8. Kunjathoor V.V., Febbraio M., Podrez E.A., Moore K.J., Andersson L., Koehn S., Rhee J.S., Silverstein R., Hoff H.F., and Freeman M.W. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 277 (2002) 49982-49988
9. de Winther M.P., van Dijk K.W., Havekes L.M., and Hofker M.H. Macrophage scavenger receptor class A: a multifunctional receptor in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 290-297
10. Rohrer L., Freeman M., Kodama T., Penman M., and Krieger M. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature 343 (1990) 570-572
11. Kodama T., Freeman M., Rohrer L., Zabrecky J., Matsudaira P., and Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 343 (1990) 531-535
12. Chen Y., Wang X., Ben J., Yue S., Bai H., Guan X., Bai X., Jiang L., Ji Y., Fan L., and Chen Q. The di-leucine motif contributes to class a scavenger receptor-mediated internalization of acetylated lipoproteins. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1317-1322
13. Kosswig N., Rice S., Daugherty A., and Post S.R. Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains. J. Biol. Chem. 278 (2003) 34219-34225
14. Morimoto K., Wada Y., Hinagata J., Imanishi T., Kodama T., and Doi T. VXFD in the cytoplasmic domain of macrophage scavenger receptors mediates their efficient internalization and cell-surface expression. Biol. Pharm. Bull. 22 (1999) 1022-1026
15. Fong L.G., and Le D. The processing of ligands by the class A scavenger receptor is dependent on signal information located in the cytoplasmic domain. J. Biol. Chem. 274 (1999) 36808-36816
16. Liao H.S., Matsumoto A., Itakura H., Doi T., Honda M., Kodama T., and Geng Y.J. Transcriptional inhibition by interleukin-6 of the class A macrophage scavenger receptor in macrophages derived from human peripheral monocytes and the THP-1 monocytic cell line. Arterioscler. Thromb. Vasc. Biol. 19 (1999) 1872-1880
17. Stephan Z.F., and Yurachek E.C. Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL. J. Lipid Res. 34 (1993) 325-330
18. Kawano T., Hakamata H., Ohta T., Ding Y., Yoshida M., Ueda S., and Horiuchi S. Inhibitory effects of HepG2 cell-derived apolipoprotein A-I-containing lipoproteins on cholesteryl ester accumulation in macrophages. Biochemistry 36 (1997) 9816-9825
19. Zhao M., and Weissleder R. Intracellular cargo delivery using tat peptide and derivatives. Med. Res. Rev. 24 (2004) 1-12
20. Suzuki H., Kurihara Y., Takeya M., Kamada N., Kataoka M., Jishage K., Ueda O., Sakaguchi H., Higashi T., Suzuki T., Takashima Y., Kawabe Y., Cynshi O., Wada Y., Honda M., Kurihara H., Aburatani H., Doi T., Matsumoto A., Azuma S., Noda T., Toyoda Y., Itakura H., Yazaki Y., Kodama T., et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386 (1997) 292-296
21. Nakamura T., Hinagata J., Tanaka T., Imanishi T., Wada Y., Kodama T., and Doi T. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem. Biophys. Res. Commun. 290 (2002) 858-864
22. Nakamura T., Suzuki H., Wada Y., Kodama T., and Doi T. Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-kappaB-dependent signaling pathways through macrophage scavenger receptors. Biochem. Biophys. Res. Commun. 343 (2006) 286-294
23. Sano H., Ishino M., Kramer H., Shimizu T., Mitsuzawa H., Nishitani C., and Kuroki Y. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. J. Biol. Chem. 282 (2007) 7973-7981
24. Kay B.K., Kasanov J., and Yamabhai M. Screening phage-displayed combinatorial peptide libraries. Methods 24 (2001) 240-246
25. Hetian L., Ping A., Shumei S., Xiaoying L., Luowen H., Jian W., Lin M., Meisheng L., Junshan Y., and Chengchao S. A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor. J. Biol. Chem. 277 (2002) 43137-43142
26. Yang B., Gao L., Li L., Lu Z., Fan X., Patel C.A., Pomerantz R.J., DuBois G.C., and Zhang H. Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency virus type 1 (HIV-1) Vif proteins. J. Biol. Chem. 278 (2003) 6596-6602
27. Chen Y., Sankala M., Ojala J.R., Sun Y., Tuuttila A., Isenman D.E., Tryggvason K., and Pikkarainen T. A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO. J. Biol. Chem. 281 (2006) 12767-12775
28. Fuh G., Pisabarro M.T., Li Y., Quan C., Lasky L.A., and Sidhu S.S. Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display. J. Biol. Chem. 275 (2000) 21486-21491
29. Brooks H., Lebleu B., and Vives E. Tat peptide-mediated cellular delivery: back to basics. Adv. Drug Deliv. Rev. 57 (2005) 559-577
30. Moore K.J., Kunjathoor V.V., Koehn S.L., Manning J.J., Tseng A.A., Silver J.M., McKee M., and Freeman M.W. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J. Clin. Invest. 115 (2005) 2192-2201
31. Suzuki H., Kurihara Y., Takeya M., Kamada N., Kataoka M., Jishage K., Sakaguchi H., Kruijt J.K., Higashi T., Suzuki T., van Berkel T.J., Horiuchi S., Takahashi K., Yazaki Y., and Kodama T. The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and susceptibility to infection in MSR knockout mice. J. Atheroscler. Thromb. 4 (1997) 1-11
32. Gianturco S.H., Bradley W.A., Gotto Jr. A.M., Morrisett J.D., and Peavy D.L. Hypertriglyceridemic very low density lipoproteins induce triglyceride synthesis and accumulation in mouse peritoneal macrophages. J. Clin. Invest. 70 (1982) 168-178
33. Hsu H.Y., Chiu S.L., Wen M.H., Chen K.Y., and Hua K.F. Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways. J. Biol. Chem. 276 (2001) 28719-28730
34. Ricci R., Sumara G., Sumara I., Rozenberg I., Kurrer M., Akhmedov A., Hersberger M., Eriksson U., Eberli F.R., Becher B., Boren J., Chen M., Cybulsky M.I., Moore K.J., Freeman M.W., Wagner E.F., Matter C.M., and Luscher T.F. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306 (2004) 1558-1561