Pharmacological fMRI - Challenges in analysing drug-induced single-Event BOLD responses

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volumn , Issue , 2007, Pages 3411-3416

  Pohlmann, Andreas ^a,b   Barjat, Hervé ^b   Tilling, Lorna C ^b   James, Michael F ^b  

^a IEEE

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BRAIN; DRUG DELIVERY;

BOLD SIGNALS; CONTRAST BASED PHMRI;

MAGNETIC RESONANCE IMAGING;

DRUG; OXYGEN;

ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD; BRAIN; BRAIN MAPPING; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; DRUG EFFECT; EVALUATION STUDY; IMAGE ENHANCEMENT; MALE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ALGORITHMS; ANIMALS; BRAIN; BRAIN MAPPING; COMPUTER SIMULATION; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MODELS, NEUROLOGICAL; OXYGEN; PHARMACEUTICAL PREPARATIONS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 57649180047     PISSN: 05891019     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2007.4353064     Document Type: Conference Paper

References (15)

1. W. S. Rusband, ImageJ, U.S. National Institutes of Health, Bethesda, Maryland, USA, http://rsb.info.nih.gov/ij/, 1997-2007.
2. FMRIB Software Library, FMRIB, Oxford, UK, www.fmrib.ox.ac.uk
3. SPM99, Institute of Neurology, London, UK, www.fil.ion.ucl.ac.uk
4. th Ann. Meeting Org. for Human Brain Mapping, Budapest, Hungary, 2004.
5. V.D. Calhoun, et al, "A method for making group inferences from fMRI data using ICA", Hum. Brain Map., vol. 14, pp. 140-151, 2001.
6. P. Wang, and J-M. Zhu, "Mapping pharmacological-evoked fMRI data using ICA-derived PD modeling", Proc. ISMRM, p. 3271, 2006.
7. N. Easton, et al, "Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast", Psychopharm, 189, pp. 369-385, 2006.
8. C.L. Littlewood, et al, "Mapping the central effects of ketamine in the rat using phMRI", Psychopharm, 186, pp. 64-81, 2006.
9. A.J. Schwarz, et al, "A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: Application to phMRI", NeuroImage, 32, pp. 538-550, 2006.
10. R.G.Wise, and I. Tracey, "The role of fMRI in drug discovery", JMRI, 23, pp. 862-876, 2006.
11. N. Easton, et al, "Atomoxetine produces changes in cortico-basal thalamic loop circuits: Assessed by phMRI BOLD contrast", Neuropharm, 52, pp. 812-826, 2007.
12. K. Hewitt, et al, "Behavioural and pharmacological MRI assessment of the effects of methylphenidate in a potential new rat model of attention deficit hyperactivity disorder", Psychopharm, 180, pp. 716-723, 2005.
13. N. Jones, et al, "Examining the neural targets of the AMPA receptor potentiator LY404187 in the rat brain using pharmacological MRI", Psychopharm, 180, pp. 743-751, 2005.
14. M.D. Ireland, et al, "Mapping the effects of the selective dopamine D2/D3 receptor agonist quinelorane using pharmacological MRI", Neuroscience, 133, pp. 315-326, 2005.
15. A. Gozzi, et al, "Region-specific effects of nicotine on brain activity: a pharmacological MRI study in the drug-naive rat", Neurospychopharm, 31, pp. 1690-1703, 2006.