Effect of methyl substitution in a ligand on the selectivity and binding affinity for a nucleobase: A case study with isoxanthopterin and its derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 351-359

  Rajendar, Burki ^a   Rajendran, Arivazhagan ^a   Sato, Yusuke ^a   Nishizawa, Seiichi ^a,b   Teramae, Norio ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Abasic site; Effect of methyl substitution; Fluorescence; Nucleobase recognition; Single nucleotide polymorphisms

Indexed keywords

3 METHYLISOXANTHOPTERIN; ADENINE; ASPEROPTERIN B; CYTOSINE; GUANINE; ISOXANTHOPTERIN; LIGAND; METHYL GROUP; PTERIN DERIVATIVE; THYMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; ENTHALPY; STOICHIOMETRY; STRUCTURE ANALYSIS; THERMODYNAMICS;

BINDING SITES; CALORIMETRY; CYTOSINE; LIGANDS; METHYLATION; PYRIMIDINONES; THERMODYNAMICS; THYMINE; XANTHOPTERIN;

EID: 57649176767     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.062     Document Type: Article

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