Computational modeling of a metabolic pathway in ceramide de novo synthesis

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volumn , Issue , 2007, Pages 1405-1408

  Dhingra, Shobhika ^a   Freedenberg, Melissa ^a   Quo, Chang F ^a   Merrill Jr , Alfred H ^b   Wang, May D ^a  

^a Emory University   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOCHEMICAL ENGINEERING; BIOSYNTHESIS; METABOLISM; MOLECULAR BIOLOGY; ONCOLOGY;

BIOCHEMICAL KINETICS; CERAMIDE DE NOVO SYNTHESIS; COMPUTATIONAL MODELING; HEURISTIC STRATEGY; MOLECULAR AGENTS;

CELL DEATH;

CERAMIDE; MULTIENZYME COMPLEX;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ALGORITHMS; CERAMIDES; COMPUTER SIMULATION; GENE EXPRESSION REGULATION; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; SIGNAL TRANSDUCTION;

EID: 57649158775     PISSN: 05891019     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2007.4352561     Document Type: Conference Paper

References (15)

1. Reynolds P C, Maurer B J, and Kolesnick R N. "Ceramide synthesis and metabolism as a target for cancer therapy." Cancer Letters. 2003 Aug 13; 206: 169-180.
2. Christoph M, et al. "Characterization of ceramide synthesis." J Biol Chem. 1997; 272(36): 22432-22437.
3. Maceyka, M. et al. "SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism." J. Biol Chemistry (2005). 280;37118-37129.
4. Wells, G, Dickson, R, Lester, R. "Heat-induced elevation of ceramide in saccharomyces cerevisiae via de novo synthesis." J Biol Chem. 1998; 273:7235-7243.
5. Jenkins, G M, Coward, A, Signorelli, P, Pettus B J, Chalfant, C E, Hannun, Y A. "Acute activation of the de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins." J Biol Chem. 2002; 277: 42572-42578.
6. Riebeling, C, Allegood, J C, Wang, E, Merrill, A H, Futerman, A H. "Two mammalian longevity assurance gene (LAG1) family members, trhl and trh4, regulate dihydroceramide synthesis using different fatty acyl-coA donors." J Biol Chem. 2003; 278: 43452-43459.
7. King, E L, and Altman, C. "A schematic method of deriving the rate laws for enzyme-catalyzed reactions." Jour Amer Chem Soc. 1956; 60: 1375-1378.
8. D. Voet, J.G. Voet, and C. W. Pratt, Fundamentals of Biochemistry. New York: Wiley, 1999.
9. "Lipid Maps." 1 Jun 2007 〈http://www.lipidmaps.org〉.
10. Hanada, K. "Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism." Biochimica et Biophysica Acta. 2003; 1632: 16-30.
11. Pewzner-Jung, Y, Ben-Dor, S, and Futerman, A. "When do Lasses (longevity assurance genes) become CerS (ceramide synthases)." J Biol Chem. 2006;281:25001-25005.
12. Schulz, A et al. "The CLN9 protein, a regulator of dihydroceramide synthase." J Biol Chem. 2006;281:2784-2794.
13. Maceyka, M et al. "SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism." J Biol Chem. 2005;280: 37118-37129.
14. Ma L, and Iglesias, P A. "Quantifying robustness of biochemical network models." BMC Bioinformatics. 2002; 3: 38.
15. van Riel N A W. "Dynamic modeling and analysis of biochemical networks: mechanism-based models and model-based experiments." Briefings in Bioinformatics. 2006; 7(4): 364-374.