Prostaglandin E2 negatively regulates AMP-activated protein kinase via protein kinase A signaling pathway

Prostaglandins and Other Lipid Mediators

Volumn 88, Issue 1-2, 2009, Pages 31-35

  Funahashi, Koji ^a,b   Cao, Xia ^a   Yamauchi, Masako ^a   Kozaki, Yasuko ^c   Ishiguro, Naoki ^b   Kambe, Fukushi ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KINJO GAKUIN UNIVERSITY   (Japan)

Author keywords

AMP activated protein kinase; Osteoblasts; Phosphorylation; Prostaglandin E2; Prostaglandin receptor agonist; Protein kinase A

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN E3; SERINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; HUMANS; MICE; OSTEOBLASTS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 57649157661     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2008.09.002     Document Type: Article

References (21)

1. Kahn B.B., Alquier T., Carling D., and Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1 (2005) 15
2. Hardie D.G., and Sakamoto K. AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda) 21 (2006) 48
3. 2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2 (2005) 21
4. Hawley S.A., Pan D.A., Mustard K.J., et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2 (2005) 9
5. Hardie D.G. New roles for the LKB1→AMPK pathway. Curr Opin Cell Biol 17 (2005) 167
6. Kola B., Boscaro M., Rutter G.A., Grossman A.B., and Korbonits M. Expanding role of AMPK in endocrinology. Trends Endocrinol Metab 17 (2006) 205
7. Sugimoto Y., and Narumiya S. Prostaglandin E receptors. J Biol Chem 282 (2007) 11613
8. Cao X., Kambe F., Moeller L.C., Refetoff S., and Seo H. Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. Mol Endocrinol 19 (2005) 102
9. Cao X., Kambe F., Lu X., Kobayashi N., Ohmori S., and Seo H. Glutathionylation of two cysteine residues in paired domain regulates DNA binding activity of Pax-8. J Biol Chem 280 (2005) 25901
10. Lu X., Kambe F., Cao X., et al. DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147 (2006) 3123
11. Garcia T., Roman-Roman S., Jackson A., et al. Behavior of osteoblast, adipocyte, and myoblast markers in genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro. Bone 31 (2002) 205
12. Hurley R.L., Barre L.K., Wood S.D., et al. Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem 281 (2006) 36662
13. Horman S., Vertommen D., Heath R., et al. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem 281 (2006) 5335
14. Wayman G.A., Tokumitsu H., and Soderling T.R. Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade. J Biol Chem 272 (1997) 16073
15. 2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. J Biol Chem 274 (1999) 10086
16. Raisz L.G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115 (2005) 3318
17. Ke H.Z., Crawford D.T., Qi H., et al. A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats. J Bone Miner Res 21 (2006) 565
18. Li M., Ke H.Z., Qi H., et al. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res 18 (2003) 2033
19. Suzawa T., Miyaura C., Inada M., et al. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141 (2000) 1554
20. Brodie M.J., Hensby C.N., Parke A., and Gordon D. Is prostacyclin in the major pro-inflammatory prostanoid in joint fluid?. Life Sci 27 (1980) 603
21. Honda T., Segi-Nishida E., Miyachi Y., and Narumiya S. Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. J Exp Med 203 (2006) 325