Lewy body pathology in long-term fetal nigral transplants: Is Parkinson's disease transmitted from one neural system to another?

Neuropsychopharmacology

Volumn 34, Issue 1, 2009, Pages 254-

  Kordower, Jeffrey H ^a   Brundin, Patrik ^b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; UBIQUITIN;

BRAIN NERVE CELL; CELL THERAPY; CELL TRANSPLANTATION; CORPUS STRIATUM; DISEASE TRANSMISSION; DOPAMINERGIC NERVE CELL; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEWY BODY; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; REINNERVATION; SHORT SURVEY; SUBSTANTIA NIGRA; TISSUE GRAFT;

FETAL TISSUE TRANSPLANTATION; HUMANS; LEWY BODIES; PARKINSON DISEASE; SUBSTANTIA NIGRA;

EID: 57649138491     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.161     Document Type: Short Survey

References (6)

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3. Kordower JH, Freeman T, Snow BJ, Vingerhoets FJG, Mufson E, Sanberg PR et al (1995). Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Eng J Med 332: 1118-1124.
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5. Kordower JH, Chu Y, Hauser RA, Freeman T, Olanow CW (2008). Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14: 504-507.
6. Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ et al (2008). Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 14: 501-503.