De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC

Journal of Biological Chemistry

Volumn 283, Issue 46, 2008, Pages 31469-31476

  Arredondo, Silvia ^a   Segatori, Laura ^a,d   Gilbert, Hiram F ^c   Georgiou, George ^a,b,e  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b The University of Texas at Austin   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Rice University   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RESISTANCE; AMINES; AMINO ACIDS; BACTERIOLOGY; CATALYSTS; COPPER COMPOUNDS; DIMERIZATION; ELECTRON TRANSITIONS; ENZYMES; ESCHERICHIA COLI; ISOMERIZATION; ISOMERS; ORGANIC ACIDS; PROTEIN FOLDING; SITE SELECTION;

ACTIVE SITES; AMINO ACID SUBSTITUTIONS; BINDING CLEFTS; BINDING POCKETS; CATALYTIC DOMAINS; DE NOVO DESIGNS; DIMERIZATION DOMAINS; DISULFIDE BOND FORMATIONS; DISULFIDE BONDS; DISULFIDE ISOMERASE; DO-MAINS; E. COLI; HOMODIMER; IN-VIVO; ISOMERASE; ISOMERASES; KEY FEATURES; PERIPLASMIC; PHYSIOLOGICAL CONDITIONS; PROTEIN DIMERIZATION; SEQUENCE HOMOLOGIES; STRUCTURAL ORGANIZATIONS; SUBSTRATE PROTEINS; THIOREDOXIN;

PROTEINS;

AMINO ACID; BACTERIAL ENZYME; COPPER CHLORIDE; DISULFIDE ISOMERASE; ISOMERASE; PROLINE; THIOREDOXIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHIMERA; CONCENTRATION (PARAMETERS); CYTOPLASM; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; ESCHERICHIA COLI; EUKARYOTE; ISOMERIZATION; MOLECULAR EVOLUTION; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROKARYOTE; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; DISULFIDES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTATION; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; PROTEIN DISULFIDE-ISOMERASES; PROTEIN ENGINEERING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA;

EID: 57649138449     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803346200     Document Type: Article

References (43)

1. Kadokura, H., Katzen, F., and Beckwith, J. (2003) Annu. Rev. Biochem. 72, 111-135
2. Collet, J. F., and Bardwell, J. C. (2002) Mol. Microbiol. 44, 1-8
3. Grauschopf, U., Fritz, A., and Glockshuber, R. (2003) EMBO J. 22, 3503-3513
4. Berkmen, M., Boyd, D., and Beckwith, J. (2005) J. Biol. Chem. 280, 11387-11394
5. Messens, J., and Collet, J. F. (2006) Int. J. Biochem. Cell Biol. 38, 1050-1062
6. Tian, G., Xiang, S., Noiva, R., Lennarz, W. J., and Schindelin, H. (2006) Cell 124, 61-73
7. Kulp, M. S., Frickel, E. M., Ellgaard, L., and Weissman, J. S. (2006) J. Biol. Chem. 281, 876-884
8. Segatori, L., Murphy, L., Arredondo, S., Kadokura, H., Gilbert, H., Beckwith, J., and Georgiou, G. (2006) J. Biol. Chem. 281, 4911-4919
9. Yeh, S. M., Koon, N., Squire, C., and Metcalf, P. (2007) Acta Crystallogr. D. Biol. Crystallogr. 63, 465-471
10. Sun, X. X., and Wang, C. C. (2000) J. Biol. Chem. 275, 22743-22749
11. Zhao, Z., Peng, Y., Hao, S. F., Zeng, Z. H., and Wang, C. C. (2003) J. Biol. Chem. 278, 43292-43298
12. Bader, M. W., Hiniker, A., Regeimbal, J., Goldstone, D., Haebel, P. W., Riemer, J., Metcalf, P., and Bardwell, J. C. (2001) EMBO J. 20, 1555-1562
13. Segatori, L., Paukstelis, P. J., Gilbert, H. F., and Georgiou, G. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 10018-10023
14. Lundstrom, J., Krause, G., and Holmgren, A. (1992) J. Biol. Chem. 267, 9047-9052
15. Jonda, S., Huber-Wunderlich, M., Glockshuber, R., and Mossner, E. (1999) EMBO J. 18, 3271-3281
16. Guzman, L. M., Belin, D., Carson, M. J., and Beckwith, J. (1995) J. Bacteriol. 177, 4121-4130
17. Bessette, P. H., Aslund, F., Beckwith, J., and Georgiou, G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 13703-13708
18. Brickman, E., and Beckwith, J. (1975) J. Mol. Biol. 96, 307-316
19. Fromant, M., Blanquet, S., and Plateau, P. (1995) Anal. Biochem. 224, 347-353
20. Holmgren, A. (1979) J. Biol. Chem. 254, 9627-9632
21. Lyles, M. M., and Gilbert, H. F. (1991) Biochemistry 30, 613-619
22. Buchner, J., Grallert, H., and Jakob, U. (1998) Methods Enzymol. 290, 323-338
23. Krause, G., Lundstrom, J., Barea, J. L., Pueyo de la Cuesta, C., and Holmgren, A. (1991) J. Biol. Chem. 266, 9494-9500
24. Chivers, P. T., Laboissiere, M. C., and Raines, R. T. (1996) EMBO J. 15, 2659-2667
25. Pack, P., and Pluckthun, A. (1992) Biochemistry 31, 1579-1584
26. Qiu, J., Swartz, J. R., and Georgiou, G. (1998) Appl. Environ Microbiol. 64, 4891-4896
27. Saul, F. A., Arie, J. P., Vulliez-le Normand, B., Kahn, R., Betton, J. M., and Bentley, G. A. (2004) J. Mol. Biol. 335, 595-608
28. Bessette, P. H., Cotto, J. J., Gilbert, H. F., and Georgiou, G. (1999) J. Biol. Chem. 274, 7784-7792
29. Kamitani, S., Akiyama, Y., and Ito, K. (1992) EMBO J. 11, 57-62
30. Hiniker, A., Collet, J. F., and Bardwell, J. C. (2005) J. Biol. Chem. 280, 33785-33791
31. Guilhot, C., Jander, G., Martin, N. L., and Beckwith, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9895-9899
32. Kishigami, S., Kanaya, E., Kikuchi, M., and Ito, K. (1995) J. Biol. Chem. 270, 17072-17074
33. Gruber, C. W., Cemazar, M., Heras, B., Martin, J. L., and Craik, D. J. (2006) Trends Biochem. Sci. 31, 455-464
34. Hawkins, H. C., Blackburn, E. C., and Freedman, R. B. (1991) Biochem. J. 275 (Pt 2), 349-353
35. Lundstrom-Ljung, J., and Holmgren, A. (1995) J. Biol. Chem. 270, 7822-7828
36. Ruoppolo, M., Orru, S., Talamo, F., Ljung, J., Pirneskoski, A., Kivirikko, K. I., Marino, G., and Koivunen, P. (2003) Protein Sci. 12, 939-952
37. Debarbieux, L., and Beckwith, J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 10751-10756
38. Chivers, P. T., Prehoda, K. E., and Raines, R. T. (1997) Biochemistry 36, 4061-4066
39. Martin, J. L. (1995) Structure 3, 245-250
40. McCarthy, A. A., Haebel, P. W., Torronen, A., Rybin, V., Baker, E. N., and Metcalf, P. (2000) Nat. Struct. Biol. 7, 196-199
41. Foloppe, N., and Nilsson, L. (2004) Structure 12, 289-300
42. Huber-Wunderlich, M., and Glockshuber, R. (1998) Fold Des. 3, 161-171
43. Grauschopf, U., Winther, J. R., Korber, P., Zander, T., Dallinger, P., and Bardwell, J. C. (1995) Cell 83, 947-955