Adult neurogenesis, cell cycle and drug discovery in psychiatry

Neuropsychopharmacology

Volumn 34, Issue 1, 2009, Pages 244-

  Pechnick, Robert N ^a,b,c   Chesnokova, Vera ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; IMIPRAMINE;

CELL CYCLE REGULATION; DEPRESSION; DRUG DESIGN; DRUG MECHANISM; DRUG RESEARCH; DRUG TARGETING; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY;

ADULT; ANIMALS; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG DISCOVERY; HUMANS; MENTAL DISORDERS; NEUROGENESIS;

EID: 57649129459     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.164     Document Type: Short Survey

References (6)

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2. Duman RS (2004). Depression: a case of neuronal life and death? Biol Psychiatry 56: 140-145.
3. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA et al (1998). Neurogenesis in the adult human hippocampus. Nat Med 4: 1313-1317.
4. Gould E (2007). How widespread is adult neurogenesis in mammals? Nat Rev Neurosci 8: 481-488.
5. Pechnick RN, Zonis S, Wawrowsky K, Pourmorady J, Chesnokova V (2008). p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus. Proc Natl Acad Sci USA 105: 1358-1363.
6. Scharfman HE, Hen R (2007). Is more neurogenesis always better? Science 315: 336-338.